SMILE

Study of the molecular and cellular mechanisms of incentive learning

 Coordinatore INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore France [FR]
 Totale costo 2˙500˙000 €
 EC contributo 2˙500˙000 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2009-AdG
 Funding Scheme ERC-AG
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-06-01   -   2016-05-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Dr.
Nome: Jean-Antoine Charles Maurice
Cognome: Girault
Email: send email
Telefono: 33145876152
Fax: 33145876132

FR (PARIS) hostInstitution 2˙500˙000.00
2    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

 Organization address address: 101 Rue de Tolbiac
city: PARIS
postcode: 75654

contact info
Titolo: Ms.
Nome: Isabelle
Cognome: Verdier
Email: send email
Telefono: +331 48 07 34 33
Fax: +331 48 07 34 32

FR (PARIS) hostInstitution 2˙500˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

related    striatal    behavioral    neuronal    cellular    molecular    mechanisms    alterations    mechanism    traces    incentive    learning    populations    memory    addiction    dopamine   

 Obiettivo del progetto (Objective)

'Incentive learning is a universal mechanism by which animals and humans learn rewarding behavioral responses. Its diversion towards the wrong targets is involved in human conditions ranging from drug addiction to pathological gambling and obesity. Incentive learning has been studied from a behavioral standpoint and only few of the underlying molecular mechanisms have been identified. We propose innovative approaches to characterize at the molecular and cellular level incentive memory traces , i.e. stable alterations in identified neuronal populations. We focus on the striatum, a brain region crucial for incentive learning, where dopamine encodes reward-related signals. Dopamine controls the flow of information through glutamatergic synapses and its long-lasting adaptations. It regulates the balance between striatal output pathways, which underlies action selection , i.e. behavioral choices in response to a given combination of internal state and external cues and context. We will address two important issues: What are the signaling mechanisms involved in the formation and reconsolidation of incentive memory traces induced by DA and glutamate? In which neuronal populations are these traces formed and what are their time-dependent modifications? The program uses a variety of approaches including novel mouse genetic models and approaches for visualizing striatal neurons in vivo. If successful, these methods have a strong potential for more general applicability. This basic research program will allow the identification of the molecular and cellular mechanisms of a simple learning mechanism with an unprecedented precision and will provide important information related to its alterations in neurological and psychiatric conditions, including addiction.'

Altri progetti dello stesso programma (FP7-IDEAS-ERC)

NEWMATS (2008)

New Directions in Hybrid Inorganic-Organic Framework Materials

Read More  

MIGPROSP (2014)

Prospects for International Migration Governance

Read More  

FUNSEL (2010)

"Generation of AAV-based, arrayed genetic libraries for in vivo functional selection: an innovative approach to identify secreted factors and microRNAs against degenerative disorders"

Read More