SYNAPSE ARCHITECTURE

Molecular architecture of the neuronal synapse

 Coordinatore MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. 

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Prof.
Nome: Wolfgang
Cognome: Baumeister
Email: send email
Telefono: +49-89-8578 2642
Fax: +49 89 8578 2641

 Nazionalità Coordinatore Germany [DE]
 Totale costo 81˙580 €
 EC contributo 81˙580 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2009-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-04-01   -   2011-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Prof.
Nome: Wolfgang
Cognome: Baumeister
Email: send email
Telefono: +49-89-8578 2642
Fax: +49 89 8578 2641

DE (MUENCHEN) coordinator 81˙580.50

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

synaptic    packets    core    transport    structural    vesicles    et    structures    dense    terminals    synapses    presynaptic    bassoon    scaffolding    functional    elucidate    cryo   

 Obiettivo del progetto (Objective)

'This project aims to unravel the molecular architecture of the structural components of the presynaptic terminal of hippocampal neurons grown in culture and to elucidate their functional properties. These are closely related to the synaptic vesicle release, one of the central questions in synaptic function, as well as with the development and maturation of synapses. The investigation of the structural relations among synaptic vesicles and between synaptic vesicles as well as other membranous and cytoskeletal structures at the presynaptic terminals are of consequence for the apprehension of neurotransmitter pools and will eventually help explain the neuronal behaviour in physiological stimulus experiments. More specifically, the project sets out to elucidate the role of large dense-core vesicles in the transport of the presynaptic scaffolding protein Bassoon Packets of dense core vesicles, together with vesicular and tubulovesicular structures, are thought to transport presynaptic scaffolding molecules such as Bassoon and Piccolo, as well as other proteins needed for the assembly of presynaptic terminals. Although these packets are mostly mobile, they can be stabilized when a stable contact with a dendrite is formed, presumably forming a nascent synapse. It has been proposed that such as the fusions of dense core vesicles with the presynaptic plasma membrane are required for the development of functional presynaptic terminals from these contacts. To achieve these objectives we are to use a cryo-electron tomography (cryo-ET) approach. Prior to the knowledge acquisition, the conditions and developing methods needed to detect synapses suitable for cryo-ET investigations in an efficient and reproducible manner must be established.'

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