Imaging liver immunopathology by intravital microscopy (IVM): a new approach to study the pathogenesis of hepatitis B virus (HBV) infection

 Coordinatore Ospedale San Raffaele 

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 Nazionalità Coordinatore Italy [IT]
 Totale costo 2˙046˙200 €
 EC contributo 2˙046˙200 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2009-AdG
 Funding Scheme ERC-AG
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-09-01   -   2016-03-31


# participant  country  role  EC contrib. [€] 

 Organization address address: Via Olgettina 60
city: MILANO
postcode: 20132

contact info
Titolo: Mr.
Nome: Mario
Cognome: Valsecchi
Email: send email
Telefono: +39 02 26432729
Fax: +39 02 26432752

IT (MILANO) beneficiary 747˙579.17
2    Ospedale San Raffaele

 Organization address address: Via Olgettina 60
city: Milano
postcode: 20132

contact info
Titolo: Ms.
Nome: Maria Rosa
Cognome: Pedrazzi
Email: send email
Telefono: +39 02 2643 5480
Fax: +39 02 2643 4717

IT (Milano) hostInstitution 1˙298˙620.83
3    Ospedale San Raffaele

 Organization address address: Via Olgettina 60
city: Milano
postcode: 20132

contact info
Titolo: Prof.
Nome: Luca
Cognome: Guidotti
Email: send email
Telefono: +39 02 26434799
Fax: +39 02 26434813

IT (Milano) hostInstitution 1˙298˙620.83


 Word cloud

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liver    hbv    infection    pathogenesis   

 Obiettivo del progetto (Objective)

'Overall objective and Specific Aims. The overall objective of this proposal is to elucidate the pathogenesis of HBV infection with the ultimate hope that this knowledge will lead to the development of new therapeutic strategies to terminate persistent infection and its attendant costs and complications. Our approach is to dissect poorly understood cellular and molecular pathways responsible for both liver disease and viral clearance taking advantage of technological advances in the field of live imaging and unique mouse models of HBV infection. Three specific aims will be pursued: 1. Visualize and characterize where and how naïve and effector CTL of different specificities adhere to vessels and recognize/kill HBV-expressing hepatocytes within the “normal”, fibrotic/cirrhotic or cancerous liver. 2. Characterize the role of platelets in HBV pathogenesis. 3. Characterize the role of Kupffer cells in HBV pathogenesis.'

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