LIVER IVM AND HBV

Imaging liver immunopathology by intravital microscopy (IVM): a new approach to study the pathogenesis of hepatitis B virus (HBV) infection

Coordinatore	Ospedale San Raffaele    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Italy [IT]
Totale costo	2˙046˙200 €
EC contributo	2˙046˙200 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2009-AdG
Funding Scheme	ERC-AG
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-09-01   -   2016-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR  Organization address address: Via Olgettina 60 city: MILANO postcode: 20132 contact info Titolo: Mr. Nome: Mario Cognome: Valsecchi Email: send email Telefono: +39 02 26432729 Fax: +39 02 26432752	IT (MILANO)	beneficiary	747˙579.17
2	Ospedale San Raffaele  Organization address address: Via Olgettina 60 city: Milano postcode: 20132 contact info Titolo: Ms. Nome: Maria Rosa Cognome: Pedrazzi Email: send email Telefono: +39 02 2643 5480 Fax: +39 02 2643 4717	IT (Milano)	hostInstitution	1˙298˙620.83
3	Ospedale San Raffaele  Organization address address: Via Olgettina 60 city: Milano postcode: 20132 contact info Titolo: Prof. Nome: Luca Cognome: Guidotti Email: send email Telefono: +39 02 26434799 Fax: +39 02 26434813	IT (Milano)	hostInstitution	1˙298˙620.83

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 Obiettivo del progetto (Objective)

'Overall objective and Specific Aims. The overall objective of this proposal is to elucidate the pathogenesis of HBV infection with the ultimate hope that this knowledge will lead to the development of new therapeutic strategies to terminate persistent infection and its attendant costs and complications. Our approach is to dissect poorly understood cellular and molecular pathways responsible for both liver disease and viral clearance taking advantage of technological advances in the field of live imaging and unique mouse models of HBV infection. Three specific aims will be pursued: 1. Visualize and characterize where and how naïve and effector CTL of different specificities adhere to vessels and recognize/kill HBV-expressing hepatocytes within the “normal”, fibrotic/cirrhotic or cancerous liver. 2. Characterize the role of platelets in HBV pathogenesis. 3. Characterize the role of Kupffer cells in HBV pathogenesis.'