SLMHC

Sheltered load at the MHC

 Coordinatore UNIVERSITY OF HULL 

 Organization address address: COTTINGHAM ROAD
city: HULL
postcode: HU6 7RX

contact info
Titolo: Ms.
Nome: Alexandra
Cognome: Galbraith
Email: send email
Telefono: +44 1482 466541
Fax: +44 1482 466862

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 180˙603 €
 EC contributo 180˙603 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2009-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-05-08   -   2011-02-07

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITY OF HULL

 Organization address address: COTTINGHAM ROAD
city: HULL
postcode: HU6 7RX

contact info
Titolo: Ms.
Nome: Alexandra
Cognome: Galbraith
Email: send email
Telefono: +44 1482 466541
Fax: +44 1482 466862

UK (HULL) coordinator 180˙603.20

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

sheltered    genome    regions    mhc    mutations    deleterious    evolution    evolutionary    locus    families    mutational    load    guppies    dr    genomic    plants    implications   

 Obiettivo del progetto (Objective)

'The accumulation of deleterious mutations and their subsequent effects on fitness play an important role in genome evolution. The mutational load is, however, not distributed evenly across the genome. In particular, genomic regions under strong balancing selection, as well as areas with little recombination are prone to accumulate mutations. In such genomic regions natural selection cannot easily purge the recessive deleterious mutations because they become rarely expressed in homozygote condition, and hence, this mutational load has been dubbed a “sheltered load”. Both the Major Histocompatibility Complex (MHC) of vertebrates and S-locus of plants are thought to carry a large sheltered load which can have important implications for the evolution of both these gene families. However, these research communities have developed their research programmes and theories independently of one another. This proposal brings together both fields for the first time in a truly synergistic collaboration that will investigate several fundamental, and yet unaddressed questions in evolutionary genetics of multigene families. It combines the expertise of the Marie Curie Fellowship applicant (Dr Llaurens) on the evolution of self incompatibility in plants and that of Dr van Oosterhout (University of Hull, UK) on MHC evolution in guppies (Poecilia reticulata). This project aims to empirically characterise the sheltered load in the MHC of guppies by using high-throughput sequencing techniques in collaboration with Prof. Dreyer (Max Planck Institute, Germany). We will furthermore investigate the evolutionary and ecological implications of this MHC-linked sheltered load by using laboratory crosses and field experiments. The comparison between MHC and S-locus evolution will help us to elucidate the population genetic and molecular mechanisms associated with the sheltered load, and solve several longstanding scientific enigmas of the MHC.'

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