RAPHE

Cell-type specific features of serotonergic neurons in the raphe nuclei

Coordinatore	FUNDACAO CALOUSTE GULBENKIAN    more  Organization address address: AVENIDA DE BERNA 45A city: LISBOA postcode: 1000 contact info Titolo: Mr. Nome: José Mário Cognome: Leite Email: send email Telefono: +351 214407937 Fax: +351 214407970
Nazionalità Coordinatore	Portugal [PT]
Totale costo	156˙364 €
EC contributo	156˙364 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2009-IEF
Funding Scheme	MC-IEF
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-05-01   -   2012-04-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	FUNDACAO CALOUSTE GULBENKIAN  Organization address address: AVENIDA DE BERNA 45A city: LISBOA postcode: 1000 contact info Titolo: Mr. Nome: José Mário Cognome: Leite Email: send email Telefono: +351 214407937 Fax: +351 214407970	PT (LISBOA)	coordinator	156˙364.40

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 Obiettivo del progetto (Objective)

'Serotonin (5-Hydroxytryptamine, 5-HT) has long been known to be involved in a variety of behavioral, cognitive and emotional processes and is commonly pharmacologically targeted in the treatment of some major psychiatric and neurological diseases. Most of the brain 5-HT innervation arises from a specific neuronal network in the brainstem, the raphe nuclei RN. For a better understanding of the brain 5-HT functions an in depth knowledge of RN network is required with a special emphasis on the activity of 5-HT neurons, since these can be directly linked to 5-HT release. Despite great interest in 5-HT function, relatively little is known about the activity of 5-HT cells in relation to behavior mainly because technical difficulties in identifying the neurochemical identity of the cells recorded. Here we propose an optogenetic approach which will allow us to to identify the neurochemical and anatomical identity of neurons recorded in behaving animals. In combination with specific behavioral paradigms, these experiments could provide insights into novel aspects of 5-HT function. The results obtained could have important pathophysiological implications.'