STEMREPAIR

Novel mesenchymal stem cell based therapies for articular cartilage repair

 Coordinatore  

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore Non specificata
 Totale costo 1˙499˙770 €
 EC contributo 1˙499 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-09-01   -   2015-08-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN

 Organization address address: College Green -
city: DUBLIN
postcode: 2

contact info
Titolo: Dr.
Nome: Daniel John
Cognome: Kelly
Email: send email
Telefono: +353 1 8963947
Fax: +353 1 6795554

IE (DUBLIN) hostInstitution 1˙499˙770.40
2    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN

 Organization address address: College Green -
city: DUBLIN
postcode: 2

contact info
Titolo: Ms.
Nome: Deirdre
Cognome: Savage
Email: send email
Telefono: 35318961942
Fax: 35317071633

IE (DUBLIN) hostInstitution 1˙499˙770.40

Mappa

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 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

cells    culture    therapies    defects    defect    cartilage    theme    zonal    determine    articular    therapy    microbead    engineer    structure    aci    repair    tissue    limited    functional   

 Obiettivo del progetto (Objective)

'Once damaged articular cartilage has a limited reparative capacity and thus lesions often progress to arthritis. This has motivated the development of cell based therapies for the repair of cartilage defects such as autologous chondrocyte implantation (ACI). Such therapies are limited in two ways. Firstly, they do not result in the regeneration of hyaline cartilage and hence the repair is temporary. Secondly, widespread adaptation into the clinical setting is impeded by practical issues such as the high fiscal cost and time required for culture expansion of chondrocytes. The applicant is of the belief that both issues cannot currently be addressed by a single new therapy. Therefore the proposed project will put forward separate solutions to both issues. The first theme of the project will determine whether freshly isolated (not culture expanded) infrapatellar fat pad derived cells, embedded in a hydrogel containing microbead-encapsulated growth factors, can used to engineer functional cartilage tissue. A component of this theme will involve magnetic microbead enrichment for cells with surface markers associated with highly chondrogenic cells. Theme 2 of the proposed project will explore an alternative therapy for cartilage defect repair. Specifically, the objective is to tissue engineer in vitro a functional tissue with a zonal structure mimicking that of normal articular cartilage using mesenchymal stem cells. It is hypothesised that such a zonal structure can be generated by controlling the oxygen tension and mechanical environment within the developing tissue. The final theme of the project will be to determine if repairing high-load bearing cartilage defects using either tissue engineering therapies will result in significantly improved repair compared to ACI in a cartilage defect model.'

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