VASCULOFLOW

Understanding the dynamics of vasculogenesis from a biomechanical perspective

 Coordinatore CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE 

 Organization address address: Rue Laurent Fries 1
city: ILLKIRCH GRAFFENSTADEN
postcode: 67404

contact info
Titolo: Dr.
Nome: Steve
Cognome: Brooks
Email: send email
Telefono: 00 33 3 88 65 33 94
Fax: 00 33 3 88 65 32 03

 Nazionalità Coordinatore France [FR]
 Totale costo 173˙662 €
 EC contributo 173˙662 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2009-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-07-01   -   2012-07-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE

 Organization address address: Rue Laurent Fries 1
city: ILLKIRCH GRAFFENSTADEN
postcode: 67404

contact info
Titolo: Dr.
Nome: Steve
Cognome: Brooks
Email: send email
Telefono: 00 33 3 88 65 33 94
Fax: 00 33 3 88 65 32 03

FR (ILLKIRCH GRAFFENSTADEN) coordinator 173˙662.40

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

vascular    flow    experimental    genetic    forces    blood    vivo    techniques    morphogenesis    cardiovascular    imaging    hemodynamic    live    patterns   

 Obiettivo del progetto (Objective)

'The cardiovascular system is vital to every vertebrate and is the first functional organ in the developing embryo. As a consequence, the heartbeats generate hemodynamic forces that physically stimulate growing arteries and veins at the earliest steps of cardiovascular development. The mechanisms involved in vascular morphogenesis are poorly understood. One of the fundamental questions is whether vascular morphogenesis depends solely on genetic pre-programming or whether additional environmental cues provided by blood flow are needed. To date, the experimental data are few and somewhat controversial. This might be due to the fact that understanding of the roles of hemodynamic forces is challenging since flow patterns are highly dynamic and only accessible in live embryos. Thus, addressing the contribution of blood flow during cardiovascular development not only necessitates imaging techniques to visualize and quantify the flow forces but also proper experimental methods to alter and modify them in vivo. Primarily, this proposal is focused on developing fast imaging approaches allowing the visualization of blood flow patterns in specific regions of the cardiovascular system and the effect flow altering treatments on endothelial cells at different developmental stages. Secondarily, these experiments will be combined with molecular biology techniques to identify the genes activated by flows and conventional imaging to characterize the effects of flow alterations. In particular, we will develop live flow reporters to correlate the flow response with gene expression in vivo. The insights gained from these in vivo studies will significantly increase our knowledge on how genetic networks interact with their physical environment during vascular development. Ultimately, this work should lead to relevant findings for a better understanding of congenital cardiovascular diseases.'

Altri progetti dello stesso programma (FP7-PEOPLE)

CONCORT (2011)

The CONsumer COmpetence Research Training

Read More  

TBKO (2013)

Synthesis and Biological Evaluation of a Potent Antituberculosis Natural Product and Analogues

Read More  

MELANIN EVOLUTION (2010)

The role of oxidative stress for the evolution of traits generated by melanins

Read More