NCRNANEURO

Non-coding RNAs in neurodegeneration

Coordinatore	VIB    more  Organization address address: Rijvisschestraat 120 city: ZWIJNAARDE - GENT postcode: 9052 contact info Titolo: Mr. Nome: Rik Cognome: Audenaert Email: send email Telefono: -2446588 Fax: -2446587
Nazionalità Coordinatore	Belgium [BE]
Totale costo	214˙800 €
EC contributo	214˙800 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2009-IIF
Funding Scheme	MC-IIF
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-10-01   -   2012-09-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	VIB  Organization address address: Rijvisschestraat 120 city: ZWIJNAARDE - GENT postcode: 9052 contact info Titolo: Mr. Nome: Rik Cognome: Audenaert Email: send email Telefono: -2446588 Fax: -2446587	BE (ZWIJNAARDE - GENT)	coordinator	214˙800.00

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 Obiettivo del progetto (Objective)

'Large non-coding RNAs and microRNAs are important regulators of gene expression that may control both physiological and pathological processes such as neurodegenerative disorders. Given the complexity of neurodegenerative disorders, studying the role of non-coding RNAs would be necessary to understand the molecular mechanisms underlying ageing related neurodegeneration. Of particular interest, microRNAs (miRNAs) seem to participate directly in the regulation of Alzheimer’s Disease (AD) and Parkinson’s Disease (PD) related genes. In this regard, microRNA research would be promising for the understanding of the very prevalent and poorly understood sporadic forms of AD and possibly PD. To address the role of specific microRNAs in biological models, the project will consist in determining whether down-regulation of specific microRNAs in zebrafish and mouse models recapitulate neurodegeneration. The identification of mRNA targets of such microRNAs will provide insight into the cellular pathways that are disturbed after microRNA knock-down. To complement the study on microRNAs, another objective of the project will be to determine whether large non-coding RNAs are dysregulated in neurodegenerative diseases similar to what is observed for microRNAs. The study of non-coding RNAs will provide a novel layer of complexity in neuronal cell biology and be exciting tools to probe and discover molecular mechanisms underlying neurodegeneration.'