ESAMY

Efficient Synthesis using Alkynes as Masked Ylides

 Coordinatore THE UNIVERSITY OF BIRMINGHAM 

 Organization address address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT

contact info
Titolo: Ms.
Nome: May
Cognome: Chung
Email: send email
Telefono: +44 1 214158202
Fax: +44 1 214146056

 Nazionalità Coordinatore United Kingdom [UK]
 Totale costo 172˙240 €
 EC contributo 172˙240 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2009-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-08-09   -   2012-08-08

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM

 Organization address address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT

contact info
Titolo: Ms.
Nome: May
Cognome: Chung
Email: send email
Telefono: +44 1 214158202
Fax: +44 1 214146056

UK (BIRMINGHAM) coordinator 172˙240.80

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

vital    reactions    precursors    functionalities    synthetic    chemical    ylides    significant    simple    material    efficiency    sulfur    coupling    molecules    amounts    synthesis   

 Obiettivo del progetto (Objective)

'The chemicals arena is vital to our continued way of life, be it though materials synthesis, agrochemicals, pharmaceutical production or in biological probes. All these areas depend on our ability to make molecules. This is achieved by the coupling of fragments, and the manipulation of various functionalities. This process can be time-consuming, produce large amounts of waste material and require the use of significant amounts of limited resources, not least energy and chemical precursors. Therefore it is vital that we develop more efficient, cleaner and quicker strategies for molecular synthesis. The current best methods to prepare the valuable reactive intermediates known as sulfur ylides, employ the use of complex and potentially dangerous functionalities. As these are ultimately lost from the material, only after having been introduced at significant cost, these routes are rendered unattractive in terms of safe-handling and synthetic efficiency. In this proposal we show a way in which sulfur-ylides can be prepared directly from simple, readily available precursors, without the currently associated problems. This method employs gold catalysis, and will be used to develop new reactions that allow the preparation of complex molecules by the coupling of simple units. The products will be of significant use, as either final targets or in synthesis of compounds of importance. In this proposal, new reactions will be developed that show high synthetic efficiency and flexibility. The reactions will be established and their scope and limitations probed to demonstrate their applicability to the chemical community.'

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