GREENLATPOL

Mechanisms underlying lateral polarity establishment in plant cells

Coordinatore	more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Non specificata
Totale costo	1˙363˙452 €
EC contributo	1˙363˙452 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2010-StG_20091118
Funding Scheme	ERC-S
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-12-01   -   2016-11-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UMEA UNIVERSITET  Organization address address: UNIVERSITETOMRADET city: UMEA postcode: 901 87 contact info Titolo: Ms. Nome: Ylva Cognome: Johansson Email: send email Telefono: +46 90 7866623 Fax: +46 90 58050	SE (UMEA)	beneficiary	800˙960.48
2	UNIVERSITAET POTSDAM  Organization address address: AM NEUEN PALAIS 10 city: POTSDAM postcode: 14469 contact info Titolo: Dr. Nome: Adriana Cognome: Wipperling Email: send email Telefono: +49 331 9771190 Fax: +49 331 9771298	DE (POTSDAM)	hostInstitution	562˙491.52
3	UNIVERSITAET POTSDAM  Organization address address: AM NEUEN PALAIS 10 city: POTSDAM postcode: 14469 contact info Titolo: Prof. Nome: Markus Cognome: Grebe Email: send email Telefono: +49 331 9772651 Fax: +49 331 9772512	DE (POTSDAM)	hostInstitution	562˙491.52

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 Obiettivo del progetto (Objective)

'Higher plants and animals establish elaborate body plans with one end of the organism being different from another. Polar organisation is also of fundamental importance at the single-cell level, because mutations affecting cell polarity may cause severe body deformations. Hence, cell polarity is a central theme of biological research and much progress has been made towards our understanding of cellular polarisation along the shoot-root (apical-basal) axis of plants. By contrast, how polarity is established towards inner and outer lateral membranes of plant cells remains unresolved. Here, I propose to identify components controlling lateral cell polarity, employing the root epidermis of the genetic model plant Arabidopsis as an excellent system readily accessible for cell biological analyses. Root epidermal cells display polar nuclear movement towards the inner lateral membrane and proteins located at the outer lateral membrane. We will employ tools for visualization of these polar events that will enable us to A) perform forward genetic screens to discover signals and requirements for polar nuclear movement and outer lateral membrane polarity, B) apply forward and reverse genetics to unravel cytoskeletal requirements of lateral polarisation, C) employ live-cell imaging to reveal the dynamics of polarising events and D) combine genetic and cellular analyses with regulators of apical-basal polarity. Our work will uncover how a single cell separates and integrates polarising events along diverse axes. The proposed research is groundbreaking, as it will lay foundations for an understanding of lateral polarity establishment in plants. Finally, it will aid our understanding of how mechanisms underlying polarising events evolved differently in diverse multicellular organisms.'