Moonlight-dependent Hormones Orchestrating Lunar Reproductive Periodicity and Regeneration


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 Nazionalità Coordinatore Austria [AT]
 Totale costo 1˙500˙000 €
 EC contributo 1˙500˙000 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2010-StG_20091118
 Funding Scheme ERC-SG
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-12-01   -   2016-07-31


# participant  country  role  EC contrib. [€] 

 Organization address address: UNIVERSITATSRING 1
city: WIEN
postcode: 1010

contact info
Titolo: Dr.
Nome: Florian
Cognome: Raible
Email: send email
Telefono: +43 664 60277 54616

AT (WIEN) hostInstitution 1˙500˙000.00

 Organization address address: UNIVERSITATSRING 1
city: WIEN
postcode: 1010

contact info
Titolo: Dr.
Nome: Helmut
Cognome: Schaschl
Email: send email
Telefono: +43 1 4277 18218
Fax: +43 1 4277 18229

AT (WIEN) hostInstitution 1˙500˙000.00


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

pioneer    reproductive    cycles    hormonal    regeneration    maturation    cycle    periodicity    successful    screen    nature    observations    animals    lunar    molecular    first    us   

 Obiettivo del progetto (Objective)

'The moon governs reproductive cycles in a broad range of marine animals, including cnidarians, polychaetes, crustaceans, echinoderms and fishes. Even outside the animals, lunar reproductive cycles have been described, such as in brown algae or foraminifers. Despite their fundamental nature, and decades of classical observations, close to nothing is known about the molecular processes that underly these lunar reproductive cycles.

We will take advantage of the recent advance in molecular resources and tools in the bristle worm Platynereis dumerilii, which has long served as a key model for classical experimental studies on lunar periodicity. The combination of modern techniques with well-founded classical observations will allow us to decipher, for the first time, the hormonal cues that are regulated by the lunar cycle and are responsible for the orchestration of gonadal maturation and trunk regeneration.

The project builds on established methodology, as well as on the first results of a successful pioneer screen and has three major aims: (1) the functional investigation of two hormones we recently identified to be under lunar cycle control. (2) the extension of our successful pioneer screen to understand to which extent other neurohormonal components change over the lunar phase. (3) the identification of the elusive inhibitory brain hormone that directly acts on the gonads to inhibit premature maturation.

Together, these experiments will lead us to first significant insights into the molecular nature of the hormonal network that underlies moonlight-dependent periodicity and regeneration.'

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