STEM CELL REGULATION

GENE REGULATORY NETWORK CONTROLLING THE ROOT STEM CELL NICHE IN ARABIDOPSIS THALIANA

 Coordinatore ALBERT-LUDWIGS-UNIVERSITAET FREIBURG 

 Organization address address: FAHNENBERGPLATZ
city: FREIBURG
postcode: 79085

contact info
Titolo: Prof.
Nome: Thomas
Cognome: Laux
Email: send email
Telefono: +49 761 2032943

 Nazionalità Coordinatore Germany [DE]
 Totale costo 168˙863 €
 EC contributo 168˙863 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2010-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-03-01   -   2014-02-28

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    ALBERT-LUDWIGS-UNIVERSITAET FREIBURG

 Organization address address: FAHNENBERGPLATZ
city: FREIBURG
postcode: 79085

contact info
Titolo: Prof.
Nome: Thomas
Cognome: Laux
Email: send email
Telefono: +49 761 2032943

DE (FREIBURG) coordinator 168˙863.20

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

candidates    niche    shoot    wox    center    downstream    plant    qc    gene    genes    root    cells    stem    homeobox    cell   

 Obiettivo del progetto (Objective)

'Plant stem cells are located in apical meristems at the growing tips of the shoot and the root. Signals from the neighboring organizing center within the shoot or quiescent center (QC) within the root maintain the stem cells in an undifferentiated state. The homeobox gene WUSCHEL-RELATED HOMEOBOX 5 (WOX5) is QC-specifically expressed and plays a central role in the control of the distal stem cells. However, the downstream factors of WOX5 and the molecular events triggered by WOX5 activity are not understood. Therefore, this project is intended to identify WOX5 primary target genes and to elucidate the roles of factors acting downstream of WOX5 in stem cell regulation. From pilot experiments, the first candidates for WOX5 target genes have been identified. I will perform a thorough transcriptome profiling of the QC, verify candidates by WOX5 protein -DNA binding studies in vivo, and by functional characterization. Furthermore, systems biology approach of the WOX5 downstream factors will be used for the construction of a regulatory network involved in stem cell niche signaling. Taken together, the proposed project will deepen the knowledge of how cell-cell communication in the stem cell niche functions.'

Introduzione (Teaser)

Scientists have investigated how a certain gene controls stem cell differentiation in plant roots.

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