PREDICT

EVALUATION OF LIPID LEVELS PRIOR AND DURING GESTATION AND ASSOCIATION WITH ADVERSE PREGNANCY OUTCOMES AND SUBSEQUENT DEVELOPMENT OF TRUE DYSLIPIDEMIA. POPULATION BASED STUDY

 Coordinatore CLALIT HEALTH SERVICES 

 Organization address address: ARLOZOROV STREET 101
city: TEL AVIV
postcode: 62098

contact info
Titolo: Dr.
Nome: Shlomi
Cognome: Codish
Email: send email
Telefono: 97286403449
Fax: 97286277364

 Nazionalità Coordinatore Israel [IL]
 Totale costo 100˙000 €
 EC contributo 100˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2010-RG
 Funding Scheme MC-IRG
 Anno di inizio 2011
 Periodo (anno-mese-giorno) 2011-04-01   -   2015-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    CLALIT HEALTH SERVICES

 Organization address address: ARLOZOROV STREET 101
city: TEL AVIV
postcode: 62098

contact info
Titolo: Dr.
Nome: Shlomi
Cognome: Codish
Email: send email
Telefono: 97286403449
Fax: 97286277364

IL (TEL AVIV) coordinator 100˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

cohort    outcomes    elevated    density    gestational    physical    group    medical    blood    pregnancy    syndrome    lt    tests    women    dyslipidemia    history    metabolic    adverse    obesity    dl    pressure    examination    levels    risk    years    mg    lipoprotein    triglycerides    percentile   

 Obiettivo del progetto (Objective)

'Background: The metabolic syndrome is characterized by a group of metabolic risk factors such as obesity (mainly abdominal obesity), atherogenic dyslipidemia (high triglycerides, low HDL cholesterol), elevated blood pressure and dysglycemia. Several components of the metabolic syndrome (glucose intolerance and elevated blood pressure) are known risk factors for development of pregnancy complications. The objective of the proposed study is to characterize the metabolic syndrome and especially disturbance of lipid homeostasis over the reproductive cycle of women life starting from preconception assessment, through gestational period and during three years following birth. Study cohort The study population of 600 women undergoing pre-pregnancy routine assessment will be enrolled. At the baseline detailed medical history assessment, physical examination and blood tests will be performed. This cohort will undergo the similar assessment at weeks 12, 24 and at the delivery.This cohort will be assessed again annually for 3 years following the delivery (medical history; physical examination and blood tests). Hypotheses: 1) Elevated triglycerides levels (≥150mg/dL) and/or low levels of high density lipoprotein (<50mg/dL) assessed prior to conception are associated with preeclampsia/ eclampsia, and/or gestational diabetes mellitus. 2) Elevated triglycerides levels (>75 percentile for the appropriate gestational age) and/or low levels of high density lipoprotein (<25 percentile) assessed during the gestation are associated with the adverse pregnancy outcomes. 3) Women with elevated triglycerides levels and low levels of high density lipoprotein during pregnancy have higher rates of metabolic syndrome at 3 years after the delivery. Importance: Our study will help to identify additional risk factor for adverse pregnancy outcomes and identify a risk group for development of insulin resistance associated pathologies such as dyslipidemia and metabolic syndrome.'

Altri progetti dello stesso programma (FP7-PEOPLE)

R-D-SBES-R (2011)

R & D in Sustainable Building Energy Systems and Retrofitting

Read More  

PI3K-C2-SIG (2013)

Signalling mechanisms of the class II isoforms of PI 3-kinase

Read More  

DECODER (2011)

DECiphering the role of long non COding Rna in cancer

Read More