BIOMATE

Soft Biomade Materials: Modular Protein Polymers and their nano-assemblies

Coordinatore	WAGENINGEN UNIVERSITY    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Netherlands [NL]
Totale costo	2˙497˙044 €
EC contributo	2˙497˙044 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2010-AdG_20100224
Funding Scheme	ERC-AG
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-05-01   -   2016-04-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	STICHTING DIENST LANDBOUWKUNDIG ONDERZOEK  Organization address address: Costerweg 50 city: WAGENINGEN postcode: 6701BH contact info Titolo: Mr. Nome: Ruben Cognome: Van Deursen Email: send email Telefono: +31 317 482985	NL (WAGENINGEN)	beneficiary	497˙369.77
2	WAGENINGEN UNIVERSITY  Organization address address: DROEVENDAALSESTEEG 4 city: WAGENINGEN postcode: 6708 PB contact info Titolo: Mr. Nome: Tom Cognome: Bessems Email: send email Telefono: +31 317 484478 Fax: +31 317 484132	NL (WAGENINGEN)	hostInstitution	1˙999˙674.25
3	WAGENINGEN UNIVERSITY  Organization address address: DROEVENDAALSESTEEG 4 city: WAGENINGEN postcode: 6708 PB contact info Titolo: Prof. Nome: Martinus Abraham Cognome: Cohen Stuart Email: send email Telefono: +31 317 483369 Fax: 31317483777	NL (WAGENINGEN)	hostInstitution	1˙999˙674.25

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'From a polymer chemistry perspective, the way in which nature produces its plethora of different proteins is a miracle of precision: the synthesis of each single molecule is directed by the sequence information chemically coded in DNA. The present state of recombinant DNA technology should in principle allow us to make genes that code for entirely new, very sophisticated amino acid polymers, which are chosen and designed by man to serve as new polymer materials. It has been shown that it is indeed possible to make use of the protein biosynthetic machinery and produce such de novo protein polymers, but it is not clear what their potentials are in terms of new materials with desired functionalities. I propose to develop a new class of protein polymers, chosen such that they form nanostructured materials by triggered folding and multimolecular assembly. The plan is based on three innovative ideas: (i) each new protein polymer will be constructed from a limited set of selected amino acid sequences, called modules (hence the term modular protein polymers) (ii) new, high-yield fermentation strategies will be developed so that polymers will become available in significant quantities for evaluation and application; (iii) the design of modular protein polymers is carried out as a cyclic process in which sequence selection, construction of artificial genes, optimisation of fermentation for high yield, studying polymer folding and assembly, and modelling of the nanostructure by molecular simulation are all logically connected, allowing efficient selection of target sequences. This project is a cross-road. It brings together biotechnology and polymer science, creating a unique set of biomaterials for medical and pharmaceutical use, that can be easily extended into a manifold of biofunctional materials. Moreover, it will provide us with fresh tools and valuable insights to tackle the subtle relations between protein sequence and folding.'