BREAST CANCER ORIGIN

Analysis of the cellular origin of breast cancer

Coordinatore	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE    more  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Prof. Nome: Christine Jannette Cognome: Watson Email: send email Telefono: +44 1223 333725 Fax: +44 1223 333346
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	200˙049 €
EC contributo	200˙049 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2010-IEF
Funding Scheme	MC-IEF
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-08-01   -   2013-07-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE  Organization address address: The Old Schools, Trinity Lane city: CAMBRIDGE postcode: CB2 1TN contact info Titolo: Prof. Nome: Christine Jannette Cognome: Watson Email: send email Telefono: +44 1223 333725 Fax: +44 1223 333346	UK (CAMBRIDGE)	coordinator	200˙049.60

Mappa

 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

 Obiettivo del progetto (Objective)

'Breast cancer is a heterogeneous disease, which includes many different types of cancers with diverse histopathologies, genetic and genomic variations, and clinical outcomes. Pathological states of the breast, such as pre-neoplastic lesions and carcinomas, retain aspects of cellular composition observed in the normal breast. It is not clear if the heterogeneity of breast cancer reflects the same hierarchical pattern of the normal tissue. In particular, the question remains as to whether specific molecular pathways establish the subtype of breast cancer or whether different cell types within the breast hierarchy become transformed and give rise to each tumour subtype. Currently, one of the major limitations in the field consists of a lack of experimental model systems that correctly recapitulate the pathogenesis of human breast tumours. The main aim of this project is to study the cellular origin of breast cancer. In order to use a model which more closely recapitulates the human pathogenesis of breast cancer in a relatively short time frame as compared to traditional transgenic mice models, we will develop a novel system which will be used to address several important questions. The model will provide a powerful tool to dissect the contribution of oncogenes and targeted cells to the development of specific types of cancer. The system generated will also provide a relatively rapid breast cancer model which will allow us to study the contribution of selected factors, already described in the host laboratory to be important in mammary gland development and possibly tumourigenesis.'

Introduzione (Teaser)

Breast cancer is one of the leading causes of death in women. Understanding this disease at the cellular level is critical for developing personalised treatment.