GLYCOPROTEOMICS

Quantitative Glycomics and Glycoproteomics for Biomarker Discovery

 Coordinatore MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. 

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Ms.
Nome: Ulrike
Cognome: Schell
Email: send email
Telefono: +49 331 567 9195
Fax: +49 331 567 9102

 Nazionalità Coordinatore Germany [DE]
 Totale costo 100˙000 €
 EC contributo 100˙000 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2011-CIG
 Funding Scheme MC-CIG
 Anno di inizio 2011
 Periodo (anno-mese-giorno) 2011-08-01   -   2015-07-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Ms.
Nome: Ulrike
Cognome: Schell
Email: send email
Telefono: +49 331 567 9195
Fax: +49 331 567 9102

DE (MUENCHEN) coordinator 100˙000.00

Mappa


 Word cloud

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molecules    glycosylation    disease    quantitative    cell    cancer    ibd    technologies    throughput    glycoproteins   

 Obiettivo del progetto (Objective)

'In the proposed project new, integrated technologies for quantitative and high throughput glycomics, glycoproteomics and the related bioinformatics will be developed. Glycoproteins are important cell-cell communication molecules: primarily located on the membrane, glycoproteins mediate inter-cell interaction, while secreted glycoproteins can distribute throughout the whole organism via the bloodstream. The structures of the glycans attached to these glycoproteins are known to change in response to disease. With more than 50% of all human proteins being predicted to be glycosylated, there is a dearth of reproducible and quantitative analytical technologies to determine the extensive micro- and macro-heterogeneity of these molecules. In this proposal, we aim to develop novel interdisciplinary approaches to provide hitherto unknown, accurate and detailed information on the identity and quantity of glycoproteins, AND their glycosylation, simultaneously and in a high throughput manner. The lack of any template or prediction tools that allow deduction of this information makes it crucial to develop new technologies in this area. This capacity will enable the acquisition of in-depth knowledge of protein glycosylation and the investigation of the biological role of these molecules in the context of Inflammatory Bowel Diseases (IBD) such as ulcerative colitis and Crohn’s disease. The prevalence of IBD has risen in the past 10 years with every fifth IBD patient being a child or adolescent. In Germany alone more than 300 000 patients suffer from IBD. To date a cure of IBD is still not possible and IBD are suspected to increase the risk of developing colorectal cancer, which itself is already the third most common cancer in developed countries. The findings produced by this study will provide the first steps for understanding IBD onset and improving diagnostic tests and treatments.'

Altri progetti dello stesso programma (FP7-PEOPLE)

MAPACOMAS (2008)

Materials analysis based on partially correlated magnetic switching

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ISOTRACE (2013)

STABLE ISOTOPES OF METALS AS POLLUTANT TRACERS IN THE ATMOSPHERIC ENVIRONMENT

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SUBLINEAROPTML (2011)

Sublinear Optimization for Machine Learning

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