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BIOCYCLE SIGNED

BIOlogical therapy CYCLEs towards tailored, needs-driven, safer and cost-effective management of Crohn’s disease

Total Cost €

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EC-Contrib. €

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Partnership

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Project "BIOCYCLE" data sheet

The following table provides information about the project.

Coordinator
CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE 

Organization address
address: Sart Tilman B35
city: LIEGE
postcode: 4000
website: www.chuliege.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Project website http://biocycle-project.eu/
 Total cost 5˙975˙589 €
 EC max contribution 5˙975˙589 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2014-two-stage
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE BE (LIEGE) coordinator 821˙100.00
2    GROUPE D'ETUDES THERAPEUTIQUES DES AFFECTIONS INFLAMMATOIRES DIGESTIVES ASSOCIATION FR (PARIS) participant 2˙217˙600.00
3    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) participant 506˙017.00
4    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) participant 416˙435.00
5    SKANE LANS LANDSTING SE (KRISTIANSTAD) participant 352˙000.00
6    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) participant 321˙000.00
7    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 314˙271.00
8    IBDIM - IBD IN MOTION GMBH AT (WIEN) participant 239˙416.00
9    BRIDGE2HEALTH BE (LIEGE) participant 189˙500.00
10    MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER IL (RAMAT GAN) participant 165˙963.00
11    UNIVERSITE CATHOLIQUE DE LOUVAIN BE (LOUVAIN LA NEUVE) participant 122˙475.00
12    GOETEBORGS UNIVERSITET SE (GOETEBORG) participant 121˙875.00
13    CROHN'S & COLITIS FOUNDATION OF AMERICA, INC. US (NEW YORK) participant 114˙311.00
14    ASSOCIATION FRANCOIS AUPETIT FR (PARIS) participant 73˙625.00

Map

 Project objective

'The BIOCYCLE Project proposes to test and critically assess the benefits and risks of an innovative regimen for improving the treatment of Crohn’s disease (CD), a chronic immune-mediated inflammatory disease affecting the gastro-intestinal tract of an increasing number of patients. Currently, the combination of anti-TNFα monoclonal antibodies and immunosuppressants used without interruption is the gold standard for treating CD. However, long treatments are needed which raise safety concerns and costs. For maintaining the same level of efficacy while reducing risks and costs, the idea of BIOCYCLE is to use a regimen based on 'Treatment Cycles' characterized by alternating periods where both drugs are administrated and periods where only either anti-TNFα or immunosuppressant is used. The central part of the Project will be a large-scale controlled multi-centric clinical study including 300 patients in EU and USA to test the feasibility of shifting from drugs combination used without interruption (control) to Treatment Cycles (experimental arms). Primary and secondary objectives of the clinical study have already been validated for generating the best qualitative and quantitative data on clinical outcomes, predictors of disease evolution and costs. In parallel, the Project will calculate costs-of-illness associated with the different regimens and will perform surveys among patients, caregivers and healthcare systems representatives to assess their readiness to include/support Treatment Cycles in the clinical practice. This will be the basis of a critical appraisal of Treatment Cycles and guidelines for helping caregivers to decide which treatment regimen best fits the specific needs of their patient. If proven, the benefits of Treatment Cycles for treating CD will be discussed with key-opinion leaders involved in the treatment of other immune-mediated inflammatory chronic diseases to support the evolution of disease-driven treatments towards needs-driven treatments.'

 Deliverables

List of deliverables.
\"BIOCYCLE Scientific and financial progress report #2\" Documents, reports 2020-04-09 08:09:28
Submission package Documents, reports 2020-04-09 08:09:28
BIOCYCLE Website Websites, patent fillings, videos etc. 2020-04-09 08:09:28

Take a look to the deliverables list in detail:  detailed list of BIOCYCLE deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Corey A. Siegel, Kimberly D. Thompson, Danielle Walls, Jan Gollins, Anne Buisson, Alain Olympie, Laurent Beaugerie, Jean-Frederic Colombel, Edouard Louis
Crohn’s disease patients’ and gastroenterologists’ perspectives towards de-escalating inflammatory bowel disease therapy
published pages: , ISSN: 1542-3565, DOI: 10.1016/j.cgh.2019.11.062
Clinical Gastroenterology and Hepatology 2020-04-09
2020 Edouard Louis
Tailoring Biologic or Immunomodulator Treatment Withdrawal in Inflammatory Bowel Disease
published pages: , ISSN: 2296-858X, DOI: 10.3389/fmed.2019.00302
Frontiers in Medicine 6 2020-04-09
2018 Nathalie Y Pauwen, Edouard Louis, Corey Siegel, Jean-Frederic Colombel, Jean Macq
Integrated Care for Crohn’s Disease: A Plea for the Development of Clinical Decision Support Systems
published pages: 1499-1504, ISSN: 1873-9946, DOI: 10.1093/ecco-jcc/jjy128
Journal of Crohn\'s and Colitis 12/12 2020-04-09
2018 Edouard Louis
Stopping Biologics in IBD—What Is the Evidence?
published pages: , ISSN: 1078-0998, DOI: 10.1093/ibd/izx098
Inflammatory Bowel Diseases 2020-04-09
2016 Jack Satsangi, Olivier Kitten, Marcela Chavez, Rahul Kalla, Nadege Prel, Marie-Alice Meuwis, Stephanie Scott, Illaria Bonetti, Nicholas T. Ventham, Edouard Louis
How to Apply for and Secure EU Funding for Collaborative IBD Research Projects
published pages: 363-370, ISSN: 1873-9946, DOI: 10.1093/ecco-jcc/jjv237
Journal of Crohn\'s and Colitis 10/3 2020-04-09
2017 Glen Doherty, Konstantinos H Katsanos, Johan Burisch, Matthieu Allez, Konstantinos Papamichael, Andreas Stallmach, Ren Mao, Ingrid Prytz Berset, Javier P Gisbert, Shaji Sebastian, Jarosław Kierkuś, Loris Lopetuso, Edyta Szymanska, Edouard Louis
European Crohn’s and Colitis Organisation Topical Review on Treatment Withdrawal [‘Exit Strategies’] in Inflammatory Bowel Disease
published pages: 17-31, ISSN: 1873-9946, DOI: 10.1093/ecco-jcc/jjx101
Journal of Crohn\'s and Colitis 12/1 2020-04-09
2015 Joana Torres, Ray K. Boyapati, Nicholas A. Kennedy, Edouard Louis, Jean-Frédéric Colombel, Jack Satsangi
Systematic Review of Effects of Withdrawal of Immunomodulators or Biologic Agents From Patients With Inflammatory Bowel Disease
published pages: 1716-1730, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2015.08.055
Gastroenterology 149/7 2020-04-09

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The information about "BIOCYCLE" are provided by the European Opendata Portal: CORDIS opendata.

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