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Novel marine biomolecules against biofilm. Application to medical devices.

Total Cost €


EC-Contrib. €






 NOMORFILM project word cloud

Explore the words cloud of the NOMORFILM project. It provides you a very rough idea of what is the project "NOMORFILM" about.

release    health    toxicity    assure    sustainable    respect    inflammation    tests    infection    marketing    assured    replaced    industrially    compounds    extracts    search    infections    screened    diverse    agreements    biosynthesis    medical    smes    animal    cultivation    antimicrobial    natural    implants    iprs    removed    entities    arise    stage    mimicking    antibiofilm    interesting    consumption    determined    ecosystems    entailing    planktonic    clinical    chemical    bioactive    nanoparticles    catheters    bacteria    manufacturing    action    source    molecules    manufacture    cultures    implant    episode    aquatic    isolated    biofilm    mechanisms    species    elucidation    antibacterial    pathogens    structural    purpose    corresponding    life    prosthetic    nomorfilm    microalgae    tissue    co    agents    treatment    secondary    bacterial    stages    anticipated    matrixes    incorporate    incorporated    ways    deeply    diminishing    models    metabolites    antibiotic   

Project "NOMORFILM" data sheet

The following table provides information about the project.


There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country Spain [ES]
 Project website
 Total cost 7˙651˙315 €
 EC max contribution 7˙651˙315 € (100%)
 Programme 1. H2020-EU.3.2. (SOCIETAL CHALLENGES - Food security, sustainable agriculture and forestry, marine, maritime and inland water research, and the bioeconomy)
 Code Call H2020-BG-2014-2
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2019-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
3    PYROGENESIS SA EL (LAVRION) participant 729˙625.00
4    UNIVERSITA DEGLI STUDI DI FIRENZE IT (Florence) participant 645˙975.00
5    KTEDOGEN SRL IT (MALNATE) participant 633˙925.00
6    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 622˙285.00
7    UNIVERSIDAD DE OVIEDO ES (OVIEDO) participant 575˙288.00
8    UNIVERSIDADE DE COIMBRA PT (COIMBRA) participant 505˙821.00
9    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 475˙000.00
11    SORBONNE UNIVERSITE FR (PARIS) participant 412˙375.00
13    UNIVERSIDAD DE ALMERIA ES (ALMERIA) participant 358˙031.00
14    CIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental PT (Porto) participant 337˙300.00
15    MBA INCORPORADO SL ES (GIJON) participant 295˙000.00
16    NANOMEDPHARMA LTD UK (LIVERPOOL) participant 246˙770.00


 Project objective

Microalgae are a source of secondary metabolites useful as new bioactive compounds. Activity of these compounds against bacterial pathogens and biofilm formation has not been determined yet. Biofilm formation is especially important in infections and tissue inflammation related to implants and catheters. These problems finally cause a release of the implant, which must be removed and replaced by a new one, entailing an increase in antibiotic consumption, together with a health costs of about 50,000-90,000 € per infection episode. Taking both problems in account, the search of new antimicrobial agents that will be effective against the bacteria in their two ways of life, planktonic and biofilm stage, is a priority need in the clinical practice. For this reason, the overall objective of NOMORFILM project is to search for antibiofilm compounds isolated from microalgae that will be useful in the treatment of this kind of infections and could be incorporated in the manufacturing of medical prosthetic devices. For this purpose, 4,000 microalgae species will be deeply screened specifically for new antibacterial and antibiofilm molecules. Structural elucidation of bioactive compounds from these extracts will assure that only new chemical entities, therefore with anticipated new mechanisms of action, will arise to further project stages, those including toxicity tests and animal models. This project also addresses the biosynthesis of the targeted bioactive compounds in sustainable microalgae co-cultures, diminishing cultivation costs by mimicking natural aquatic ecosystems. Most industrially interesting antibiofilm molecules will be incorporated into nanoparticles in order to develop manufacturing methodologies able to incorporate these compounds into real prosthetic devices matrixes. Marketing of results are assured by the presence of diverse SMEs along the manufacture and distribution of prosthetic devices, and the corresponding consortium agreements with respect to IPRs


List of deliverables.
European network database for project strains Documents, reports 2020-04-24 21:59:18
Parity document Documents, reports 2020-04-24 22:00:33
Secondary scholars contest. M42 Websites, patent fillings, videos etc. 2020-04-24 22:01:07
At least one patent Websites, patent fillings, videos etc. 2020-04-24 21:59:05
Presentation of the video clips. M51 Websites, patent fillings, videos etc. 2020-04-24 22:00:50
Secondary scholars contest. M30 Websites, patent fillings, videos etc. 2020-04-14 20:15:44
e-learning course Websites, patent fillings, videos etc. 2020-04-14 20:15:44
Roadmap for EU marine biotechnology resources national policies. M36 Documents, reports 2020-04-14 20:15:44
Secondary scholars contest. M18 Websites, patent fillings, videos etc. 2020-04-14 20:15:44
Workshop on antibiofilm issues Websites, patent fillings, videos etc. 2020-04-14 20:15:44
Random transposon library for selected pathogens Documents, reports 2020-04-14 20:15:44
Presentation of NOMORFILM webpage and leaflet Websites, patent fillings, videos etc. 2020-04-14 20:15:44
Secondary scholars contest. M9 Websites, patent fillings, videos etc. 2020-04-14 20:15:44
Roadmap for EU marine biotechnology resources national policies. M12 Documents, reports 2020-04-14 20:15:44
Presentation of the video clips. M6 Websites, patent fillings, videos etc. 2020-04-14 20:15:44

Take a look to the deliverables list in detail:  detailed list of NOMORFILM deliverables.


year authors and title journal last update
List of publications.
2019 María José Iglesias, Raquel Soengas, Clara B Martins, Maria João Correia, Joana D Ferreira, Lilia M.A. Santos, Fernando López Ortiz
Chemotaxonomic profiling through NMR
published pages: , ISSN: 0022-3646, DOI: 10.1111/jpy.12959
Journal of Phycology 2020-04-14
2020 Yuly López, Sara M. Soto
The Usefulness of Microalgae Compounds for Preventing Biofilm Infections
published pages: 9, ISSN: 2079-6382, DOI: 10.3390/antibiotics9010009
Antibiotics 9/1 2020-04-14
2018 Avinash Khandagale, Beatrice Lazzaretto, Göran Carlsson, Mikael Sundin, Sulman Shafeeq, Ute Römling, Bengt Fadeel
JAGN1 is required for fungal killing in neutrophil extracellular traps: Implications for severe congenital neutropenia
published pages: 1199-1213, ISSN: 0741-5400, DOI: 10.1002/jlb.4a0118-030rr
Journal of Leukocyte Biology 104/6 2020-04-14
2019 Virginio Cepas, Yuly López, Yaiza Gabasa, Clara B. Martins, Joana D. Ferreira, Maria J. Correia, Lília M.A. Santos, Flávio Oliveira, Vitor Ramos, Mariana Reis, Raquel Castelo-Branco, João Morais, Vitor Vasconcelos, Ian Probert, Emilie Guilloud, Mohamed Mehiri, Sara M. Soto
Inhibition of Bacterial and Fungal Biofilm Formation by 675 Extracts from Microalgae and Cyanobacteria
published pages: 77, ISSN: 2079-6382, DOI: 10.3390/antibiotics8020077
Antibiotics 8/2 2020-04-14
2019 L.K. Jensen, N.L. Henriksen, S.A. Blirup, H.E. Jensen
Guideline for Preclinical Studies of Bone Infections in Large Animals Based on a Systematic Review of 316 Non-Rodent Models
published pages: 1894-1903, ISSN: 0021-9355, DOI: 10.2106/jbjs.18.01369
The Journal of Bone and Joint Surgery 101/21 2020-04-14
2019 Giampiero Pietrocola, Giulia Nobile, Mariangela J. Alfeo, Timothy J. Foster, Joan A. Geoghegan, Vincenzo De Filippis, Pietro Speziale
Fibronectin-binding protein B (FnBPB) from Staphylococcus aureus protects against the antimicrobial activity of histones
published pages: 3588-3602, ISSN: 0021-9258, DOI: 10.1074/jbc.ra118.005707
Journal of Biological Chemistry 294/10 2020-04-14
2019 Sulman Shafeeq, Srisuda Pannanusorn, Youssef Elsharabasy, Bernardo Ramírez-Zavala, Joachim Morschhäuser, Ute Römling
Impact of manganese on biofilm formation and cell morphology of Candida parapsilosis clinical isolates with different biofilm forming abilities
published pages: , ISSN: 1567-1364, DOI: 10.1093/femsyr/foz057
FEMS Yeast Research 19/6 2020-04-14
2019 Ma José Iglesias, Raquel Soengas, Ian Probert, Emilie Guilloud, Priscillia Gourvil, Mohamed Mehiri, Yuly López, Virginio Cepas, Ignacio Gutiérrez-del-Río, Saúl Redondo-Blanco, Claudio J. Villar, Felipe Lombó, Sara Soto, Fernando López Ortiz
NMR characterization and evaluation of antibacterial and antiobiofilm activity of organic extracts from stationary phase batch cultures of five marine microalgae (Dunaliella sp., D. salina, Chaetoceros calcitrans, C. gracilis and Tisochrysis lutea)
published pages: 192-205, ISSN: 0031-9422, DOI: 10.1016/j.phytochem.2019.05.001
Phytochemistry 164 2020-04-14
2020 Freja Lea Lüthje, Sophie Amalie Blirup-Plum, Nadia Sara Møller, Peter M.H. Heegaard, Henrik Elvang Jensen, Klaus Kirketerp-Møller, Hans Gottlieb, Kerstin Skovgaard, Louise Kruse Jensen
The host response to bacterial bone infection involves a local upregulation of several acute phase proteins
published pages: 151914, ISSN: 0171-2985, DOI: 10.1016/j.imbio.2020.151914
Immunobiology 2020-04-14
2020 Freja Lea Lüthje, Louise Kruse Jensen, Henrik Elvang Jensen, Kerstin Skovgaard
The inflammatory response to bone infection – a review based on animal models and human patients
published pages: , ISSN: 0903-4641, DOI: 10.1111/apm.13027
APMIS 2020-04-14
2019 Paolo Monciardini, Alice Bernasconi, Marianna Iorio, Cristina Brunati, Margherita Sosio, Laura Campochiaro, Paolo Landini, Sonia I. Maffioli, Stefano Donadio
Antibacterial Aromatic Polyketides Incorporating the Unusual Amino Acid Enduracididine
published pages: 35-44, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.8b00354
Journal of Natural Products 82/1 2020-04-14
2017 Vitor Ramos, João Morais, Raquel Castelo-Branco, Ângela Pinheiro, Joana Martins, Ana Regueiras, Ana L. Pereira, Viviana R. Lopes, Bárbara Frazão, Dina Gomes, Cristiana Moreira, Maria Sofia Costa, Sébastien Brûle, Silvia Faustino, Rosário Martins, Martin Saker, Joana Osswald, Pedro N. Leão, Vitor M. Vasconcelos
Cyanobacterial diversity held in microbial biological resource centers as a biotechnological asset: the case study of the newly established LEGE culture collection
published pages: , ISSN: 0921-8971, DOI: 10.1007/s10811-017-1369-y
Journal of Applied Phycology 2020-04-14
2018 Louise Kruse Jensen, Nicole Lind Henriksen, Thomas Bjarnsholt, Kasper Nørskov Kragh, Henrik Elvang Jensen
Combined Staining Techniques for Demonstration of Staphylococcus aureus Biofilm in Routine Histopathology
published pages: 27-36, ISSN: 2206-3552, DOI: 10.7150/jbji.22799
Journal of Bone and Joint Infection 3/1 2020-04-14
2017 Cristina Brunati, Thomas T Thomsen, Eleonora Gaspari, Sonia Maffioli, Margherita Sosio, Daniela Jabes, Anders Løbner-Olesen, Stefano Donadio
Expanding the potential of NAI-107 for treating serious ESKAPE pathogens: synergistic combinations against Gram-negatives and bactericidal activity against non-dividing cells
published pages: 414-424, ISSN: 0305-7453, DOI: 10.1093/jac/dkx395
Journal of Antimicrobial Chemotherapy 73/2 2020-04-14
2017 Louise K. Jensen, Anne S. B. Johansen, Henrik E. Jensen
Porcine Models of Biofilm Infections with Focus on Pathomorphology
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2017.01961
Frontiers in Microbiology 8 2020-04-14
2019 P. Gkomoza, G.S. Lampropoulos, M. Vardavoulias, D.I. Pantelis, P.N. Karakizis, Ch. Sarafoglou
Microstructural investigation of porous titanium coatings, produced by thermal spraying techniques, using plasma atomization and hydride-dehydride powders, for orthopedic implants
published pages: 947-956, ISSN: 0257-8972, DOI: 10.1016/j.surfcoat.2018.10.072
Surface and Coatings Technology 357 2020-04-14
2019 P. Gkomoza, M. Vardavoulias, D.I. Pantelis, Ch. Sarafoglou
Comparative study of structure and properties of thermal spray coatings using conventional and nanostructured hydroxyapatite powder, for applications in medical implants
published pages: 748-758, ISSN: 0257-8972, DOI: 10.1016/j.surfcoat.2018.10.044
Surface and Coatings Technology 357 2020-04-14
2018 Yuly López, Virginio Cepas, Sara M. Soto
Chapter 1: The Marine Ecosystem as a Source of Antibiotics
published pages: 3-48, ISSN: , DOI: 10.1007/978-3-319-69075-9_1
Grand Challenges in Marine Biotechnology 2020-04-14
2019 Louise Kruse Jensen, Thomas Bjarnsholt, Kasper N. Kragh, Bent Aalbæk, Nicole Lind Henriksen, Sophie Amalie Blirup, Karen Pankoke, Andreas Petersen, Henrik Elvang Jensen
In Vivo Gentamicin Susceptibility Test for Prevention of Bacterial Biofilms in Bone Tissue and on Implants
published pages: e01889-18, ISSN: 0066-4804, DOI: 10.1128/aac.01889-18
Antimicrobial Agents and Chemotherapy 63/2 2020-04-14
2015 Sara M. Soto
The sea as a source of antibiotics
published pages: , ISSN: 2327-5073, DOI:
Clinical Microbiology: Open Access Volume 4, Issue 4, 1000e126 2020-04-14
2015 Sara M. Soto González and Felipe Lombó Brugos
Biopelículas y su relación con las infecciones protésicas
published pages: 36 to 43, ISSN: 2444-1171, DOI:
Ortopedia & geriatría profesional Año 1. Número 3. tercer trime 2020-04-14
2016 Pietrocola G, Nobile G, Gianotti V, Zapotoczna M, Foster TJ, Geoghegan JA, Speziale P.
Molecular interactions of human plasminogen with FnBPB, a fibrinogen/fibronectin-binding protein from Staphylococcus aureus.
published pages: , ISSN: 1083-351X, DOI:
J Biol Chem. 2020-04-14
2020 Ignacio Gutiérrez-del-Río Nelly B. de Fraissinette Raquel Castelo-Branco Flavio Oliveira João Morais Saúl Redondo-Blanco Claudio J. Villar María José Iglesias Raquel G. Soengas Virginio Cepas Yuly López Cubillos Giacomo Sampietro Liliana Rodolfi Felipe Lombó Sara M. Soto González Fernando López Ortiz Vitor M. Vasconcelos Mariana Reis
Chlorosphaerolactylates A-D: the natural chlorinated lactylates isolated from the Portuguese cyanobacterium Sphaerospermopsis sp. LEGE 00249
published pages: , ISSN: 0000-0000, DOI: 10.26434/chemrxiv.11619873.v1
ChemRxiv 20.01.2020 2020-04-14
2017 Louise Kruse Jensen, Janne Koch, Kirstine Dich-Jorgensen, Bent Aalbaek, Andreas Petersen, Kurt Fuursted, Thomas Bjarnsholt, Kasper Nørskov Kragh, Mikkel Tøtterup, Mats Bue, Pelle Hanberg, Kjeld Søballe, Peter M.H. Heegaard, Henrik Elvang Jensen
Novel porcine model of implant-associated osteomyelitis: A comprehensive analysis of local, regional, and systemic response
published pages: 2211-2221, ISSN: 0736-0266, DOI: 10.1002/jor.23505
Journal of Orthopaedic Research 35/10 2020-04-14

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