Explore the words cloud of the CRCStemCellDynamics project. It provides you a very rough idea of what is the project "CRCStemCellDynamics" about.
The following table provides information about the project.
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
|Coordinator Country||Netherlands [NL]|
|Total cost||1˙499˙875 €|
|EC max contribution||1˙499˙875 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-04-01 to 2021-03-31|
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|1||ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM||NL (AMSTERDAM)||coordinator||1˙499˙875.00|
Annually 1.2 million new cases of colorectal cancer (CRC) are seen worldwide and over 50% of patients die of the disease making it a leading cause of cancer-related mortality. A crucial contributing factor to these disappointing figures is that CRC is a heterogeneous disease and tumours differ extensively in the clinical presentation and response to therapy. Recent unsupervised classification studies highlight that only a proportion of this heterogeneity can be explained by the variation in commonly found (epi-)genetic aberrations. Hence the origins of CRC heterogeneity remain poorly understood.
The central hypothesis of this research project is that the cell of origin contributes to the phenotype and functional properties of the pre-malignant clone and the resulting malignancy. To study this concept I will generate cell of origin- and mutation-specific molecular profiles of oncogenic clones and relate those to human CRC samples. Furthermore, I will quantitatively investigate how mutations and the cell of origin act in concert to determine the functional characteristics of the pre-malignant clone that ultimately develops into an invasive intestinal tumour. These studies are paralleled by the investigation of stem cell dynamics within established human CRCs by means of a novel marker independent lineage tracing strategy in combination with mathematical analysis techniques. This will provide critical and quantitative information on the relevance of the cancer stem cell concept in CRC and on the degree of inter-tumour variation with respect to the frequency and functional features of stem-like cells within individual CRCs and molecular subtypes of the disease. I am convinced that a better and quantitative understanding of the dynamical properties of stem cells during tumour development and within established CRCs will be pivotal for an improved classification, prevention and treatment of CRC.
|year||authors and title||journal||last update|
Kristiaan J. Lenos, Sophie C. Lodestijn, Scott K. Lyons, Maarten F. Bijlsma, DaniÃ«l M. Miedema, Louis Vermeulen
A marker-independent lineage-tracing system to quantify clonal dynamics and stem cell functionality in cancer tissue
published pages: 2648-2671, ISSN: 1754-2189, DOI: 10.1038/s41596-019-0194-y
|Nature Protocols 14/9||2019-10-10|
Maartje van der Heijden, DaniÃ«l M. Miedema, Bartlomiej Waclaw, Veronique L. Veenstra, Maria C. Lecca, Lisanne E. Nijman, Erik van Dijk, Sanne M. van Neerven, Sophie C. Lodestijn, Kristiaan J. Lenos, Nina E. de Groot, Pramudita R. Prasetyanti, Andrea Arricibita Varea, Douglas J. Winton, Jan Paul Medema, Edward Morrissey, Bauke Ylstra, Martin A. Nowak, Maarten F. Bijlsma, Louis Vermeulen
Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts
published pages: 6140-6145, ISSN: 0027-8424, DOI: 10.1073/pnas.1813417116
|Proceedings of the National Academy of Sciences 116/13||2019-10-10|
Kristiaan J. Lenos, DaniÃ«l M. Miedema, Sophie C. Lodestijn, Lisanne E. Nijman, Tom van den Bosch, Xavier Romero Ros, Filipe C. LourenÃ§o, Maria C. Lecca, Maartje van der Heijden, Sanne M. van Neerven, Anita van Oort, Nicolas Leveille, Ronja S. Adam, Felipe de Sousa E Melo, Joy Otten, Patrick Veerman, Guillaume Hypolite, Lianne Koens, Scott K. Lyons, Giorgio Stassi, Douglas J. Winton, Jan Paul Med
Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer
published pages: 1193-1202, ISSN: 1465-7392, DOI: 10.1038/s41556-018-0179-z
|Nature Cell Biology 20/10||2019-10-10|
B L N Than, J F Linnekamp, T K Starr, D A Largaespada, A Rod, Y Zhang, V Bruner, J Abrahante, A Schumann, T Luczak, A Niemczyk, M G O\'Sullivan, J P Medema, R J A Fijneman, G A Meijer, E Van den Broek, C A Hodges, P M Scott, L Vermeulen and R T Cormier
CFTR is a tumor suppressor gene in murine and human intestinal cancer
published pages: , ISSN: 1476-5594, DOI:
Nicolas LÃ©veillÃ©, Louis Vermeulen
Polycomb complex PRC1 as gatekeeper of intestinal stem cell identity
published pages: 22-22, ISSN: 2306-9759, DOI: 10.21037/sci.2016.06.03
|Stem Cell Investigation 3||2019-09-02|
Felipe de Sousa e Melo, Louis Vermeulen
Wnt Signaling in Cancer Stem Cell Biology
published pages: 60, ISSN: 2072-6694, DOI: 10.3390/cancers8070060
E Fessler, M Jansen, F De Sousa E Melo, L Zhao, P R Prasetyanti, H Rodermond, R Kandimalla, J F Linnekamp, M Franitza, S R van Hooff, J H de Jong, S C Oppeneer, C J M van Noesel, E Dekker, G Stassi, X Wang, J P Medema and L Vermeulen
A multidimensional network approach reveals microRNAs asdeterminants of the mesenchymal colorectal cancer subtype
published pages: , ISSN: 1476-5594, DOI:
AurÃ©lien de ReyniÃ¨s,
Brian M Bot,
Jeffrey S Morris,
Iris M Simon,
Felipe De Sousa E Melo,
Ganiraju C Manyam,
Joe W Gray,
Stephen H Friend,
Jan Paul Medema,
& Sabine Tejpar
The consensus molecular subtypes of colorectal cancer
published pages: , ISSN: 1546-170X, DOI:
Maartje van der Heijden,
Cheryl D. Zimberlin,
Anna M. Nicholson,
Sybren L. Meijer,
Jan Paul Medema,
Florian R. Greten,
Douglas J. Winton
& Louis Vermeulen
Bcl-2 is a critical mediator of intestinal transformation
published pages: , ISSN: 2041-1723, DOI:
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