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MAMI SIGNED

The Power of Maternal Microbes on Infant Health

Total Cost €

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EC-Contrib. €

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Partnership

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Project "MAMI" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://www.mamiproject.eu
 Total cost 1˙499˙979 €
 EC max contribution 1˙499˙979 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 1˙499˙979.00

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 Project objective

Recent reports suggest that early microbial colonization has an important role for in promoting health. This may contribute to reduce the risk of chronic diseases such as obesity, allergies and inflammatory conditions. Advances in understanding host-microbe interactions imply that maternal microbiota plays a crucial role on health programming. This process begins in utero and it is modulated by mode of delivery and diet. My research has shown that i) specific shifts in milk microbial composition are associated with lactation time and mode of delivery, ii) milk microbes drive the infant microbiota composition; iii) maternal microbiota dysbiosis may be transferred to the infant. However, factors defining maternal microbiota and its biological role upon infant’s health are not yet fully understood. Hence, this project aims to characterize maternal microbes to be transferred to neonates and determine their function in infant health programming. The specific aims are:(1) understanding how the maternal microbiome is influenced by host and environmental factors;(2) characterizing the microbial core and bioactive compounds transmitted to the offspring mainly via breastfeeding and their key roles in the microbial modulation and host response;(3) understanding the interactions among breast milk bioactive compounds and their role in infant health;(4) shedding light on how maternal microbes influence the infant immune system & (5)development of new dietary strategies and therapies based on microbial replacement and modulation. To achieve these objectives, a systems biology approach by means of state-of-the-art techniques and new methodologies based on subpopulation enrichment by flow cytometer-sorter to study host–microbe interactions will be used. Results obtained will demonstrate the interaction between infant nutrition, microbes and host response in early life and its key role in health programming, enabling new applications in the field of personalized nutrition & medicine.

 Publications

year authors and title journal last update
List of publications.
2019 Adrián Cortés-Martín, María Romo-Vaquero, Izaskun García-Mantrana, Ana Rodríguez-Varela, María Carmen Collado, Juan Carlos Espín, María Victoria Selma
Urolithin Metabotypes can Anticipate the Different Restoration of the Gut Microbiota and Anthropometric Profiles during the First Year Postpartum
published pages: 2079, ISSN: 2072-6643, DOI: 10.3390/nu11092079
Nutrients 11/9 2020-02-06
2019 Anna Parra-Llorca, María Gormaz, Sheila Lorente-Pozo, Maria Cernada, Ana García-Robles, Isabel Torres-Cuevas, Julia Kuligoswki, Maria Carmen Collado, Eva Serna, Máximo Vento
Impact of Donor Human Milk in the Preterm Very Low Birth Weight Gut Transcriptome Profile by Use of Exfoliated Intestinal Cells
published pages: 2677, ISSN: 2072-6643, DOI: 10.3390/nu11112677
Nutrients 11/11 2020-02-06
2019 Izaskun García-Mantrana, Marta Calatayud, María Romo-Vaquero, Juan Carlos Espín, María V. Selma, María Carmen Collado
Urolithin Metabotypes Can Determine the Modulation of Gut Microbiota in Healthy Individuals by Tracking Walnuts Consumption over Three Days
published pages: 2483, ISSN: 2072-6643, DOI: 10.3390/nu11102483
Nutrients 11/10 2020-02-06
2018 Carlos Gómez-Gallego, Jose Morales, Daniel Monleón, Elloise du Toit, Himanshu Kumar, Kaisa Linderborg, Yumei Zhang, Baoru Yang, Erika Isolauri, Seppo Salminen, Maria Collado
Human Breast Milk NMR Metabolomic Profile across Specific Geographical Locations and Its Association with the Milk Microbiota
published pages: 1355, ISSN: 2072-6643, DOI: 10.3390/nu10101355
Nutrients 10/10 2020-02-06
2019 Izaskun García-Mantrana, Cristina Alcántara, Marta Selma-Royo, Alba Boix-Amorós, Majda Dzidic, Jose Gimeno-Alcañiz, Isabel Úbeda-Sansano, Ignacio Sorribes-Monrabal, Ramón Escuriet, Fernando Gil-Raga, Anna Parra-Llorca, Cecilia Martínez-Costa, María Carmen Collado
MAMI: a birth cohort focused on maternal-infant microbiota during early life
published pages: , ISSN: 1471-2431, DOI: 10.1186/s12887-019-1502-y
BMC Pediatrics 19/1 2020-02-06
2019 Raul Cabrera-Rubio, Clemens Kunz, Silvia Rudloff, Izaskun García-Mantrana, Elena Crehuá-Gaudiza, Cecilia Martínez-Costa, M. Carmen Collado
Association of Maternal Secretor Status and Human Milk Oligosaccharides With Milk Microbiota
published pages: 256-263, ISSN: 0277-2116, DOI: 10.1097/MPG.0000000000002216
Journal of Pediatric Gastroenterology and Nutrition 68/2 2020-02-06
2018 Majda Dzidic, Thomas Abrahamsson, Alejandro Artacho, Maria Carmen Collado, Alex Mira, Maria C Jenmalm
Oral microbiota maturation during the first 7 years of life in relation to allergy development
published pages: , ISSN: 0105-4538, DOI: 10.1111/all.13449
Allergy 2019-07-22
2016 Izaskun Garcia-Mantrana, Maria Carmen Collado
Obesity and overweight: Impact on maternal and milk microbiome and their role for infant health and nutrition
published pages: 1865-1875, ISSN: 1613-4125, DOI: 10.1002/mnfr.201501018
Molecular Nutrition & Food Research 60/8 2019-07-22
2017 Alba Boix-Amorós, Cecilia Martinez-Costa, Amparo Querol, Maria Carmen Collado, Alex Mira
Multiple Approaches Detect the Presence of Fungi in Human Breastmilk Samples from Healthy Mothers
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-13270-x
Scientific Reports 7/1 2019-07-22
2016 Himanshu Kumar, Elloise du Toit, Amruta Kulkarni, Juhani Aakko, Kaisa M. Linderborg, Yumei Zhang, Mark P. Nicol, Erika Isolauri, Baoru Yang, Maria C. Collado, Seppo Salminen
Distinct Patterns in Human Milk Microbiota and Fatty Acid Profiles Across Specific Geographic Locations
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2016.01619
Frontiers in Microbiology 7 2019-07-22
2018 Izaskun Garcia-Mantrana, Marta Selma-Royo, Cristina Alcantara, María C. Collado
Shifts on Gut Microbiota Associated to Mediterranean Diet Adherence and Specific Dietary Intakes on General Adult Population
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2018.00890
Frontiers in Microbiology 9 2019-07-22
2016 Alba Boix-Amorós, Maria C. Collado, Alex Mira
Relationship between Milk Microbiota, Bacterial Load, Macronutrients, and Human Cells during Lactation
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2016.00492
Frontiers in Microbiology 7 2019-07-22
2016 Izaskun García-Mantrana, Bibiana Bertua, Cecilia Martínez-Costa, Maria Carmen Collado
Perinatal nutrition: How to take care of the gut microbiota?
published pages: 3-16, ISSN: 2352-9393, DOI: 10.1016/j.yclnex.2016.02.002
Clinical Nutrition Experimental 6 2019-07-22
2016 Carlos Gomez-Gallego, Izaskun Garcia-Mantrana, Seppo Salminen, María Carmen Collado
The human milk microbiome and factors influencing its composition and activity
published pages: 400-405, ISSN: 1744-165X, DOI: 10.1016/j.siny.2016.05.003
Seminars in Fetal and Neonatal Medicine 21/6 2019-07-22
2018 Majda Dzidic, Alba Boix-Amorós, Marta Selma-Royo, Alex Mira, Maria Collado
Gut Microbiota and Mucosal Immunity in the Neonate
published pages: 56, ISSN: 2076-3271, DOI: 10.3390/medsci6030056
Medical Sciences 6/3 2019-07-22
2018 Anna Parra-Llorca, María Gormaz, Cristina Alcántara, María Cernada, Antonio Nuñez-Ramiro, Máximo Vento, Maria C. Collado
Preterm Gut Microbiome Depending on Feeding Type: Significance of Donor Human Milk
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2018.01376
Frontiers in Microbiology 9 2019-07-22
2016 Maria Carmen Collado, Samuli Rautava, Juhani Aakko, Erika Isolauri, Seppo Salminen
Human gut colonisation may be initiated in utero by distinct microbial communities in the placenta and amniotic fluid
published pages: 23129, ISSN: 2045-2322, DOI: 10.1038/srep23129
Scientific Reports 6 2019-07-22
2018 Majda Dzidic, Maria C. Collado, Thomas Abrahamsson, Alejandro Artacho, Malin Stensson, Maria C. Jenmalm, Alex Mira
Oral microbiome development during childhood: an ecological succession influenced by postnatal factors and associated with tooth decay
published pages: 2292-2306, ISSN: 1751-7362, DOI: 10.1038/s41396-018-0204-z
The ISME Journal 12/9 2019-07-22
2017 Carlos Gómez-Gallego, Himanshu Kumar, Izaskun García-Mantrana, Elloise du Toit, Jukka-Pekka Suomela, Kaisa M. Linderborg, Yumei Zhang, Erika Isolauri, Baoru Yang, Seppo Salminen, M. Carmen Collado
Breast Milk Polyamines and Microbiota Interactions: Impact of Mode of Delivery and Geographical Location
published pages: 184-190, ISSN: 0250-6807, DOI: 10.1159/000457134
Annals of Nutrition and Metabolism 70/3 2019-07-22

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