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MAMI SIGNED

The Power of Maternal Microbes on Infant Health

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MAMI project word cloud

Explore the words cloud of the MAMI project. It provides you a very rough idea of what is the project "MAMI" about.

therapies transmitted microbiome offspring subpopulation shown maternal breastfeeding imply infant microbes personalized mainly replacement characterizing biological immune techniques breast programming dietary diseases composition influence microbe nutrition roles mode modulated interactions strategies lactation light function time obesity reports dysbiosis medicine allergies shedding colonization chronic begins flow cytometer reduce life biology sorter shifts health drive compounds microbiota risk diet influenced core neonates interaction environmental milk host plays enrichment transferred microbial will inflammatory suggest utero modulation bioactive recent hence

Project "MAMI" data sheet

The following table provides information about the project.

Coordinator	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	http://www.mamiproject.eu
Total cost	1˙499˙979 €
EC max contribution	1˙499˙979 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-STG
Funding Scheme	ERC-STG
Starting year	2015
Duration (year-month-day)	from 2015-06-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	coordinator	1˙499˙979.00

Map

Project objective

Recent reports suggest that early microbial colonization has an important role for in promoting health. This may contribute to reduce the risk of chronic diseases such as obesity, allergies and inflammatory conditions. Advances in understanding host-microbe interactions imply that maternal microbiota plays a crucial role on health programming. This process begins in utero and it is modulated by mode of delivery and diet. My research has shown that i) specific shifts in milk microbial composition are associated with lactation time and mode of delivery, ii) milk microbes drive the infant microbiota composition; iii) maternal microbiota dysbiosis may be transferred to the infant. However, factors defining maternal microbiota and its biological role upon infant’s health are not yet fully understood. Hence, this project aims to characterize maternal microbes to be transferred to neonates and determine their function in infant health programming. The specific aims are:(1) understanding how the maternal microbiome is influenced by host and environmental factors;(2) characterizing the microbial core and bioactive compounds transmitted to the offspring mainly via breastfeeding and their key roles in the microbial modulation and host response;(3) understanding the interactions among breast milk bioactive compounds and their role in infant health;(4) shedding light on how maternal microbes influence the infant immune system & (5)development of new dietary strategies and therapies based on microbial replacement and modulation. To achieve these objectives, a systems biology approach by means of state-of-the-art techniques and new methodologies based on subpopulation enrichment by flow cytometer-sorter to study host–microbe interactions will be used. Results obtained will demonstrate the interaction between infant nutrition, microbes and host response in early life and its key role in health programming, enabling new applications in the field of personalized nutrition & medicine.

Publications

List of publications.
year	authors and title	journal	last update
2019	AdriÃ¡n CortÃ©s-MartÃn, MarÃa Romo-Vaquero, Izaskun GarcÃa-Mantrana, Ana RodrÃguez-Varela, MarÃa Carmen Collado, Juan Carlos EspÃn, MarÃa Victoria Selma Urolithin Metabotypes can Anticipate the Different Restoration of the Gut Microbiota and Anthropometric Profiles during the First Year Postpartum published pages: 2079, ISSN: 2072-6643, DOI: 10.3390/nu11092079	Nutrients 11/9	2020-02-06
2019	Anna Parra-Llorca, MarÃa Gormaz, Sheila Lorente-Pozo, Maria Cernada, Ana GarcÃa-Robles, Isabel Torres-Cuevas, Julia Kuligoswki, Maria Carmen Collado, Eva Serna, MÃ¡ximo Vento Impact of Donor Human Milk in the Preterm Very Low Birth Weight Gut Transcriptome Profile by Use of Exfoliated Intestinal Cells published pages: 2677, ISSN: 2072-6643, DOI: 10.3390/nu11112677	Nutrients 11/11	2020-02-06
2019	Izaskun GarcÃa-Mantrana, Marta Calatayud, MarÃa Romo-Vaquero, Juan Carlos EspÃn, MarÃa V. Selma, MarÃa Carmen Collado Urolithin Metabotypes Can Determine the Modulation of Gut Microbiota in Healthy Individuals by Tracking Walnuts Consumption over Three Days published pages: 2483, ISSN: 2072-6643, DOI: 10.3390/nu11102483	Nutrients 11/10	2020-02-06
2018	Carlos GÃ³mez-Gallego, Jose Morales, Daniel MonleÃ³n, Elloise du Toit, Himanshu Kumar, Kaisa Linderborg, Yumei Zhang, Baoru Yang, Erika Isolauri, Seppo Salminen, Maria Collado Human Breast Milk NMR Metabolomic Profile across Specific Geographical Locations and Its Association with the Milk Microbiota published pages: 1355, ISSN: 2072-6643, DOI: 10.3390/nu10101355	Nutrients 10/10	2020-02-06
2019	Izaskun GarcÃa-Mantrana, Cristina AlcÃ¡ntara, Marta Selma-Royo, Alba Boix-AmorÃ³s, Majda Dzidic, Jose Gimeno-AlcaÃ±iz, Isabel Ãšbeda-Sansano, Ignacio Sorribes-Monrabal, RamÃ³n Escuriet, Fernando Gil-Raga, Anna Parra-Llorca, Cecilia MartÃnez-Costa, MarÃa Carmen Collado MAMI: a birth cohort focused on maternal-infant microbiota during early life published pages: , ISSN: 1471-2431, DOI: 10.1186/s12887-019-1502-y	BMC Pediatrics 19/1	2020-02-06
2019	Raul Cabrera-Rubio, Clemens Kunz, Silvia Rudloff, Izaskun GarcÃa-Mantrana, Elena CrehuÃ¡-Gaudiza, Cecilia MartÃnez-Costa, M. Carmen Collado Association of Maternal Secretor Status and Human Milk Oligosaccharides With Milk Microbiota published pages: 256-263, ISSN: 0277-2116, DOI: 10.1097/MPG.0000000000002216	Journal of Pediatric Gastroenterology and Nutrition 68/2	2020-02-06
2018	Majda Dzidic, Thomas Abrahamsson, Alejandro Artacho, Maria Carmen Collado, Alex Mira, Maria C Jenmalm Oral microbiota maturation during the first 7 years of life in relation to allergy development published pages: , ISSN: 0105-4538, DOI: 10.1111/all.13449	Allergy	2019-07-22
2016	Izaskun Garcia-Mantrana, Maria Carmen Collado Obesity and overweight: Impact on maternal and milk microbiome and their role for infant health and nutrition published pages: 1865-1875, ISSN: 1613-4125, DOI: 10.1002/mnfr.201501018	Molecular Nutrition & Food Research 60/8	2019-07-22
2017	Alba Boix-AmorÃ³s, Cecilia Martinez-Costa, Amparo Querol, Maria Carmen Collado, Alex Mira Multiple Approaches Detect the Presence of Fungi in Human Breastmilk Samples from Healthy Mothers published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-13270-x	Scientific Reports 7/1	2019-07-22
2016	Himanshu Kumar, Elloise du Toit, Amruta Kulkarni, Juhani Aakko, Kaisa M. Linderborg, Yumei Zhang, Mark P. Nicol, Erika Isolauri, Baoru Yang, Maria C. Collado, Seppo Salminen Distinct Patterns in Human Milk Microbiota and Fatty Acid Profiles Across Specific Geographic Locations published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2016.01619	Frontiers in Microbiology 7	2019-07-22
2018	Izaskun Garcia-Mantrana, Marta Selma-Royo, Cristina Alcantara, MarÃa C. Collado Shifts on Gut Microbiota Associated to Mediterranean Diet Adherence and Specific Dietary Intakes on General Adult Population published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2018.00890	Frontiers in Microbiology 9	2019-07-22
2016	Alba Boix-AmorÃ³s, Maria C. Collado, Alex Mira Relationship between Milk Microbiota, Bacterial Load, Macronutrients, and Human Cells during Lactation published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2016.00492	Frontiers in Microbiology 7	2019-07-22
2016	Izaskun GarcÃa-Mantrana, Bibiana Bertua, Cecilia MartÃnez-Costa, Maria Carmen Collado Perinatal nutrition: How to take care of the gut microbiota? published pages: 3-16, ISSN: 2352-9393, DOI: 10.1016/j.yclnex.2016.02.002	Clinical Nutrition Experimental 6	2019-07-22
2016	Carlos Gomez-Gallego, Izaskun Garcia-Mantrana, Seppo Salminen, MarÃa Carmen Collado The human milk microbiome and factors influencing its composition and activity published pages: 400-405, ISSN: 1744-165X, DOI: 10.1016/j.siny.2016.05.003	Seminars in Fetal and Neonatal Medicine 21/6	2019-07-22
2018	Majda Dzidic, Alba Boix-AmorÃ³s, Marta Selma-Royo, Alex Mira, Maria Collado Gut Microbiota and Mucosal Immunity in the Neonate published pages: 56, ISSN: 2076-3271, DOI: 10.3390/medsci6030056	Medical Sciences 6/3	2019-07-22
2018	Anna Parra-Llorca, MarÃa Gormaz, Cristina AlcÃ¡ntara, MarÃa Cernada, Antonio NuÃ±ez-Ramiro, MÃ¡ximo Vento, Maria C. Collado Preterm Gut Microbiome Depending on Feeding Type: Significance of Donor Human Milk published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2018.01376	Frontiers in Microbiology 9	2019-07-22
2016	Maria Carmen Collado, Samuli Rautava, Juhani Aakko, Erika Isolauri, Seppo Salminen Human gut colonisation may be initiated in utero by distinct microbial communities in the placenta and amniotic fluid published pages: 23129, ISSN: 2045-2322, DOI: 10.1038/srep23129	Scientific Reports 6	2019-07-22
2018	Majda Dzidic, Maria C. Collado, Thomas Abrahamsson, Alejandro Artacho, Malin Stensson, Maria C. Jenmalm, Alex Mira Oral microbiome development during childhood: an ecological succession influenced by postnatal factors and associated with tooth decay published pages: 2292-2306, ISSN: 1751-7362, DOI: 10.1038/s41396-018-0204-z	The ISME Journal 12/9	2019-07-22
2017	Carlos GÃ³mez-Gallego, Himanshu Kumar, Izaskun GarcÃa-Mantrana, Elloise du Toit, Jukka-Pekka Suomela, Kaisa M. Linderborg, Yumei Zhang, Erika Isolauri, Baoru Yang, Seppo Salminen, M. Carmen Collado Breast Milk Polyamines and Microbiota Interactions: Impact of Mode of Delivery and Geographical Location published pages: 184-190, ISSN: 0250-6807, DOI: 10.1159/000457134	Annals of Nutrition and Metabolism 70/3	2019-07-22

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