Opendata, web and dolomites
  1. home
  2. trasparenza
  3. open h2020
  4. tc-evo

TC-Evo SIGNED

Molecular and functional evolution of human CD8+ T cell repertoires

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 TC-Evo project word cloud

Explore the words cloud of the TC-Evo project. It provides you a very rough idea of what is the project "TC-Evo" about.

specificity    lifespan    antigen    doherty    track    interventions    tcr    equipped    human    humans    innovation    edge    gain    fine    overcome    detrimental    repertoire    beyer    sophisticated    predict    virus    underlining    disciplinary    cell    receptors    aid    repertoires    molecular    close    van    sanquin    peter    immunity    melbourne    world    insights    bioinformatics    structural    schulze    greatest    inevitably    model    lier    position    children    technological    data    vs    link    strengthen    evolution    profs    suggest    independent    immunologically    netherlands    researcher    mechanisms    elderly    yield    phases    finest    protective    platform    cells    lifetime    influenza    published    strength    chances    resident    australia    cd8    dissecting    understand    resolution    msca    adaptive    immunological    skills    biology    switches    broadly    tcrs    cutting    treatment    kedzierska    drive    adults    renowned    amsterdam    immune    vaccines    residency    tenure    fixed    gras    varies    observe    tissue    fundamental    luciani    experts   

Project "TC-Evo" data sheet

The following table provides information about the project.

Coordinator		 Stichting Sanquin Bloedvoorziening 

Organization address
address: Plesmanlaan 125
city: Amsterdam
postcode: 1006 AN
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Netherlands [NL]
 Total cost 249˙179 €
 EC max contribution 249˙179 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-GF
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    Stichting Sanquin Bloedvoorziening NL (Amsterdam) coordinator 249˙179.00
2    UNIVERSITY OF MELBOURNE AU (MELBOURNE) partner 0.00

Map

 Project objective

Humans are equipped with a sophisticated immune system, especially adaptive immunity, which is characterized by the finest antigen specificity. The evolution of such fine antigen specificity across human lifespan is far from being known, although it is observe that the strength of the adaptive immune response varies throughout human lifetime. Published data suggest that T cells receptors (TCRs) continuously change their characteristics. I aim to provide fundamental knowledge on the evolution of T cell repertoires during immunologically-distinct phases of human lifetime by dissecting the evolution of the influenza virus-specific T cell repertoire in children, adults and elderly at the greatest level of resolution and technological innovation and link this to their TCR characteristics. At the Peter Doherty Institute, Melbourne, Australia, I will use state-of-the-art comprehensive immunological analyses to identify molecular switches, which I will use to establish an immunological model to predict the strength of the CD8 T cell response. I will bring this cutting-edge multi-disciplinary platform to Europe (Sanquin, Amsterdam, The Netherlands) where I will use this platform to study the underlining mechanisms that drive tissue residency of T cells. I will gain knowledge and skills on studying TCRs, tissue resident T cells, bioinformatics and structural biology, while working in close collaboration with world-renowned experts in the field, namely Profs. Kedzierska, van Lier, Luciani, Gras, Beyer and Schulze. These state-of-the-art comprehensive immunological analyses will inevitably yield important insights into protective vs detrimental human immune responses, which will aid early interventions, treatment and help understand and overcome technical challenges of developing broadly-protective vaccines. The MSCA will strengthen my position as an independent researcher and will greatly increase my chances for a tenure-track/fixed position at an European research institute.

 Publications

year authors and title journal last update
List of publications.
2019 C. E. van de Sandt, E. B. Clemens, E. J. Grant, L. C. Rowntree, S. Sant, H. Halim, J. Crowe, A. C. Cheng, T. C. Kotsimbos, M. Richards, A. Miller, S. Y. C. Tong, J. Rossjohn, T. H. O. Nguyen, S. Gras, W. Chen, K. Kedzierska
Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-13346-4 		Nature Communications 10/1 2020-03-24
2020 Liyen Loh, Nicholas A. Gherardin, Sneha Sant, Ludivine Grzelak, Jeremy Chase Crawford, Nicola L. Bird, Hui-Fern Koay, Carolien E. van de Sandt, Marcela L. Moreira, Martha Lappas, E. Kaitlynn Allen, Jane Crowe, Thomas Loudovaris, Katie L. Flanagan, Kylie M. Quinn, Jamie Rossjohn, Paul G. Thomas, Sidonia B. G. Eckle, James McCluskey, Dale I. Godfrey, Katherine Kedzierska
Human Mucosal-Associated Invariant T Cells in Older Individuals Display Expanded TCRαβ Clonotypes with Potent Antimicrobial Responses
published pages: 1119-1133, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1900774 		The Journal of Immunology 204/5 2020-03-24
2020 Irani Thevarajan, Thi H. O. Nguyen, Marios Koutsakos, Julian Druce, Leon Caly, Carolien E. van de Sandt, Xiaoxiao Jia, Suellen Nicholson, Mike Catton, Benjamin Cowie, Steven Y. C. Tong, Sharon R. Lewin, Katherine Kedzierska
Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19
published pages: , ISSN: 1078-8956, DOI: 10.1038/s41591-020-0819-2 		Nature Medicine 2020-03-24
2018 E. Clemens, Carolien van de Sandt, Sook Wong, Linda Wakim, Sophie Valkenburg
Harnessing the Power of T Cells: The Promising Hope for a Universal Influenza Vaccine
published pages: 18, ISSN: 2076-393X, DOI: 10.3390/vaccines6020018 		Vaccines 6/2 2019-06-11
2018 Kirsty R. Short, Katherine Kedzierska, Carolien E. van de Sandt
Back to the Future: Lessons Learned From the 1918 Influenza Pandemic
published pages: , ISSN: 2235-2988, DOI: 10.3389/fcimb.2018.00343 		Frontiers in Cellular and Infection Microbiology 8 2019-05-28

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TC-EVO" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "TC-EVO" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

MY MITOCOMPLEX (2021)

Functional relevance of mitochondrial supercomplex assembly in myeloid cells

Read More  

POLINGO (2018)

The Politics of Legitimacy: Non-partisan global governance and networked INGO power in the global governance of post-war states

Read More  

CODer (2020)

The molecular basis and genetic control of local gene co-expression and its impact in human disease

Read More