TC-Evo SIGNED
Molecular and functional evolution of human CD8+ T cell repertoires
Total Cost €
0EC-Contrib. €
0Partnership
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0TC-Evo project word cloud
Explore the words cloud of the TC-Evo project. It provides you a very rough idea of what is the project "TC-Evo" about.
Project "TC-Evo" data sheet
The following table provides information about the project.
| Coordinator |
Stichting Sanquin Bloedvoorziening
Organization address contact info |
| Coordinator Country | Netherlands [NL] |
| Total cost | 249˙179 € |
| EC max contribution | 249˙179 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2017 |
| Funding Scheme | MSCA-IF-GF |
| Starting year | 2018 |
| Duration (year-month-day) | from 2018-05-01 to 2021-04-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | Stichting Sanquin Bloedvoorziening | NL (Amsterdam) | coordinator | 249˙179.00 |
| 2 | UNIVERSITY OF MELBOURNE | AU (MELBOURNE) | partner | 0.00 |
Map
Project objective
Humans are equipped with a sophisticated immune system, especially adaptive immunity, which is characterized by the finest antigen specificity. The evolution of such fine antigen specificity across human lifespan is far from being known, although it is observe that the strength of the adaptive immune response varies throughout human lifetime. Published data suggest that T cells receptors (TCRs) continuously change their characteristics. I aim to provide fundamental knowledge on the evolution of T cell repertoires during immunologically-distinct phases of human lifetime by dissecting the evolution of the influenza virus-specific T cell repertoire in children, adults and elderly at the greatest level of resolution and technological innovation and link this to their TCR characteristics. At the Peter Doherty Institute, Melbourne, Australia, I will use state-of-the-art comprehensive immunological analyses to identify molecular switches, which I will use to establish an immunological model to predict the strength of the CD8 T cell response. I will bring this cutting-edge multi-disciplinary platform to Europe (Sanquin, Amsterdam, The Netherlands) where I will use this platform to study the underlining mechanisms that drive tissue residency of T cells. I will gain knowledge and skills on studying TCRs, tissue resident T cells, bioinformatics and structural biology, while working in close collaboration with world-renowned experts in the field, namely Profs. Kedzierska, van Lier, Luciani, Gras, Beyer and Schulze. These state-of-the-art comprehensive immunological analyses will inevitably yield important insights into protective vs detrimental human immune responses, which will aid early interventions, treatment and help understand and overcome technical challenges of developing broadly-protective vaccines. The MSCA will strengthen my position as an independent researcher and will greatly increase my chances for a tenure-track/fixed position at an European research institute.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
C. E. van de Sandt, E. B. Clemens, E. J. Grant, L. C. Rowntree, S. Sant, H. Halim, J. Crowe, A. C. Cheng, T. C. Kotsimbos, M. Richards, A. Miller, S. Y. C. Tong, J. Rossjohn, T. H. O. Nguyen, S. Gras, W. Chen, K. Kedzierska Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-13346-4 |
Nature Communications 10/1 | 2020-03-24 |
| 2020 |
Liyen Loh, Nicholas A. Gherardin, Sneha Sant, Ludivine Grzelak, Jeremy Chase Crawford, Nicola L. Bird, Hui-Fern Koay, Carolien E. van de Sandt, Marcela L. Moreira, Martha Lappas, E. Kaitlynn Allen, Jane Crowe, Thomas Loudovaris, Katie L. Flanagan, Kylie M. Quinn, Jamie Rossjohn, Paul G. Thomas, Sidonia B. G. Eckle, James McCluskey, Dale I. Godfrey, Katherine Kedzierska Human Mucosal-Associated Invariant T Cells in Older Individuals Display Expanded TCRαβ Clonotypes with Potent Antimicrobial Responses published pages: 1119-1133, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1900774 |
The Journal of Immunology 204/5 | 2020-03-24 |
| 2020 |
Irani Thevarajan, Thi H. O. Nguyen, Marios Koutsakos, Julian Druce, Leon Caly, Carolien E. van de Sandt, Xiaoxiao Jia, Suellen Nicholson, Mike Catton, Benjamin Cowie, Steven Y. C. Tong, Sharon R. Lewin, Katherine Kedzierska Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19 published pages: , ISSN: 1078-8956, DOI: 10.1038/s41591-020-0819-2 |
Nature Medicine | 2020-03-24 |
| 2018 |
E. Clemens, Carolien van de Sandt, Sook Wong, Linda Wakim, Sophie Valkenburg Harnessing the Power of T Cells: The Promising Hope for a Universal Influenza Vaccine published pages: 18, ISSN: 2076-393X, DOI: 10.3390/vaccines6020018 |
Vaccines 6/2 | 2019-06-11 |
| 2018 |
Kirsty R. Short, Katherine Kedzierska, Carolien E. van de Sandt Back to the Future: Lessons Learned From the 1918 Influenza Pandemic published pages: , ISSN: 2235-2988, DOI: 10.3389/fcimb.2018.00343 |
Frontiers in Cellular and Infection Microbiology 8 | 2019-05-28 |
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