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Molecular and functional evolution of human CD8+ T cell repertoires

Total Cost €


EC-Contrib. €






 TC-Evo project word cloud

Explore the words cloud of the TC-Evo project. It provides you a very rough idea of what is the project "TC-Evo" about.

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Project "TC-Evo" data sheet

The following table provides information about the project.

Stichting Sanquin Bloedvoorziening 

Organization address
address: Plesmanlaan 125
city: Amsterdam
postcode: 1006 AN
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 249˙179 €
 EC max contribution 249˙179 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-GF
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2021-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    Stichting Sanquin Bloedvoorziening NL (Amsterdam) coordinator 249˙179.00


 Project objective

Humans are equipped with a sophisticated immune system, especially adaptive immunity, which is characterized by the finest antigen specificity. The evolution of such fine antigen specificity across human lifespan is far from being known, although it is observe that the strength of the adaptive immune response varies throughout human lifetime. Published data suggest that T cells receptors (TCRs) continuously change their characteristics. I aim to provide fundamental knowledge on the evolution of T cell repertoires during immunologically-distinct phases of human lifetime by dissecting the evolution of the influenza virus-specific T cell repertoire in children, adults and elderly at the greatest level of resolution and technological innovation and link this to their TCR characteristics. At the Peter Doherty Institute, Melbourne, Australia, I will use state-of-the-art comprehensive immunological analyses to identify molecular switches, which I will use to establish an immunological model to predict the strength of the CD8 T cell response. I will bring this cutting-edge multi-disciplinary platform to Europe (Sanquin, Amsterdam, The Netherlands) where I will use this platform to study the underlining mechanisms that drive tissue residency of T cells. I will gain knowledge and skills on studying TCRs, tissue resident T cells, bioinformatics and structural biology, while working in close collaboration with world-renowned experts in the field, namely Profs. Kedzierska, van Lier, Luciani, Gras, Beyer and Schulze. These state-of-the-art comprehensive immunological analyses will inevitably yield important insights into protective vs detrimental human immune responses, which will aid early interventions, treatment and help understand and overcome technical challenges of developing broadly-protective vaccines. The MSCA will strengthen my position as an independent researcher and will greatly increase my chances for a tenure-track/fixed position at an European research institute.


year authors and title journal last update
List of publications.
2019 C. E. van de Sandt, E. B. Clemens, E. J. Grant, L. C. Rowntree, S. Sant, H. Halim, J. Crowe, A. C. Cheng, T. C. Kotsimbos, M. Richards, A. Miller, S. Y. C. Tong, J. Rossjohn, T. H. O. Nguyen, S. Gras, W. Chen, K. Kedzierska
Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-13346-4
Nature Communications 10/1 2020-03-24
2020 Liyen Loh, Nicholas A. Gherardin, Sneha Sant, Ludivine Grzelak, Jeremy Chase Crawford, Nicola L. Bird, Hui-Fern Koay, Carolien E. van de Sandt, Marcela L. Moreira, Martha Lappas, E. Kaitlynn Allen, Jane Crowe, Thomas Loudovaris, Katie L. Flanagan, Kylie M. Quinn, Jamie Rossjohn, Paul G. Thomas, Sidonia B. G. Eckle, James McCluskey, Dale I. Godfrey, Katherine Kedzierska
Human Mucosal-Associated Invariant T Cells in Older Individuals Display Expanded TCRαβ Clonotypes with Potent Antimicrobial Responses
published pages: 1119-1133, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1900774
The Journal of Immunology 204/5 2020-03-24
2020 Irani Thevarajan, Thi H. O. Nguyen, Marios Koutsakos, Julian Druce, Leon Caly, Carolien E. van de Sandt, Xiaoxiao Jia, Suellen Nicholson, Mike Catton, Benjamin Cowie, Steven Y. C. Tong, Sharon R. Lewin, Katherine Kedzierska
Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19
published pages: , ISSN: 1078-8956, DOI: 10.1038/s41591-020-0819-2
Nature Medicine 2020-03-24
2018 E. Clemens, Carolien van de Sandt, Sook Wong, Linda Wakim, Sophie Valkenburg
Harnessing the Power of T Cells: The Promising Hope for a Universal Influenza Vaccine
published pages: 18, ISSN: 2076-393X, DOI: 10.3390/vaccines6020018
Vaccines 6/2 2019-06-11
2018 Kirsty R. Short, Katherine Kedzierska, Carolien E. van de Sandt
Back to the Future: Lessons Learned From the 1918 Influenza Pandemic
published pages: , ISSN: 2235-2988, DOI: 10.3389/fcimb.2018.00343
Frontiers in Cellular and Infection Microbiology 8 2019-05-28

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