Opendata, web and dolomites

LOCOMOUSE SIGNED

Cerebellar circuit mechanisms of coordinated locomotion in mice

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "LOCOMOUSE" data sheet

The following table provides information about the project.

Coordinator
FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD 

Organization address
address: AVENIDA BRASILIA, CENTRO DE INVESTIGACAO DA FUNDACAO CHAMPALIMAUD
city: LISBOA
postcode: 1400-038
website: http://fchampalimaud.org/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Project website http://neuro.fchampalimaud.org/en/research/investigators/research-groups/group/Carey/
 Total cost 1˙496˙750 €
 EC max contribution 1˙496˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD PT (LISBOA) coordinator 1˙496˙750.00

Map

 Project objective

A remarkable aspect of motor control is our seemingly effortless ability to generate coordinated movements. How is activity within neural circuits orchestrated to allow us to engage in complex activities like gymnastics, riding a bike, or walking down the street while drinking a cup of coffee? The cerebellum is critical for coordinated movement, and the well-described, stereotyped circuitry of the cerebellum has made it an attractive system for neural circuits research. Much is known about how activity and plasticity in its identified cell types contribute to simple forms of motor learning. In contrast, while gait ataxia, or uncoordinated walking, is a hallmark of cerebellar damage, the circuit mechanisms underlying cerebellar contributions to coordinated locomotion are not well understood. One limitation has been the difficulty in extracting quantitative measures of coordination from the complex, whole body action of locomotion. We have developed a custom-built system (LocoMouse) to analyze mouse locomotor coordination. It tracks continuous paw, snout, and tail trajectories in 3D with unprecedented spatiotemporal resolution and it has allowed us to identify specific, quantitative locomotor elements that depend on intact cerebellar function. Here we will combine this quantitative behavioral approach with electrophysiology and optogenetics to investigate circuit mechanisms of locomotor coordination. We will 1) Optogenetically silence the output of cerebellar subregions to understand their distinct contributions to locomotion. 2) Record from identified neurons and correlate their activity with specific locomotor parameters. 3) Optogenetically stimulate defined cell types to investigate circuit mechanisms of coordinated locomotion. These experiments will establish causal relationships between neural circuit activity and coordinated motor control, a problem with important implications for both health and disease.

 Publications

year authors and title journal last update
List of publications.
2019 Dana M. Darmohray, Jovin R. Jacobs, Hugo G. Marques, Megan R. Carey
Spatial and Temporal Locomotor Learning in Mouse Cerebellum
published pages: 217-231.e4, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2019.01.038
Neuron 102/1 2020-01-29
2017 Patrícia A Correia, Eran Lottem, Dhruba Banerjee, Ana S Machado, Megan R Carey, Zachary F Mainen
Transient inhibition and long-term facilitation of locomotion by phasic optogenetic activation of serotonin neurons
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.20975
eLife 6 2020-01-29
2015 Ana S Machado, Dana M Darmohray, João Fayad, Hugo G Marques, Megan R Carey
A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.07892
eLife 4 2020-01-29
2017 Albergaria C, Silva NT, Pritchett D, Carey MR
Locomotor activity modulates associative learning in mouse cerebellum.
published pages: , ISSN: , DOI: 10.1101/099721
2020-01-29

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "LOCOMOUSE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "LOCOMOUSE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

iNANOVAC4CANCER (2019)

BIOHYBRID AND BIODEGRADABLE NANOVACCINES FOR CANCER IMMUNOTHERAPY

Read More  

VictPart (2019)

Righting Victim Participation in Transitional Justice

Read More  

SuperH (2019)

Discovery and Characterization of Hydrogen-Based High-Temperature Superconductors

Read More