Explore the words cloud of the Medulloblastoma project. It provides you a very rough idea of what is the project "Medulloblastoma" about.
The following table provides information about the project.
|Coordinator Country||Sweden [SE]|
|Total cost||1˙497˙059 €|
|EC max contribution||1˙497˙059 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-05-01 to 2020-04-30|
Take a look of project's partnership.
|1||UPPSALA UNIVERSITET||SE (UPPSALA)||coordinator||1˙497˙059.00|
MYC proteins like MYC and MYCN are transcription factors that are mis-regulated in more than half of all types of human cancer including medulloblastoma, the most common brain malignancy in children. The two main challenges that can guide research in the field of pediatric brain tumors is improving survival and reducing long-term detriments due to treatment toxicities, especially from craniospinal radiotherapy. Medulloblastoma is suggested to originate from specific cells in the small brain, cerebellum. These brain tumors have recently been classified into four distinct molecular subgroups and subgroup-specific driver genes have been suggested. However, the precise role of such drivers in tumor initiation and their importance in specifying particular subgroups has not been sufficiently evaluated in proper cells of medulloblastoma origin.
We have generated clinically relevant animal models that carefully resemble some of the defined subgroups of medulloblastoma. In this proposal we intend to use the models to identify the specific cell type these brain tumors originates from. We also aim to refine our medulloblastoma models and develop novel models to define and study cells involved in brain metastasis and tumor recurrence; the main cause of death in brain tumor patients.
We have managed to culture normal human cerebellar stem cells and we now plan to model human medulloblastoma development by overexpressing oncogenes or silencing suppressor genes that are defined as clinically relevant medulloblastoma drivers. We will use a forward genetics screen to identify novel drivers and specifiers of various subtypes of medulloblastoma. We hope these combined efforts will help us better model human medulloblastoma formation and we expect to generate tumors that correlate well, both pathologically and molecularly, with primary cell cultures derived from medulloblastoma patients.
|year||authors and title||journal||last update|
Matko ÄŒanÄer, Sonja Hutter, Karl O. Holmberg, Gabriela RosÃ©n, Anders SundstrÃ¶m, Jignesh Tailor, Tobias BergstrÃ¶m, Alexandra Garancher, Magnus Essand, Robert J. Wechsler-Reya, Anna Falk, Holger Weishaupt, Fredrik J. Swartling
Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy
published pages: , ISSN: 1934-5909, DOI: 10.1016/j.stem.2019.10.005
|Cell Stem Cell 25||2019-12-16|
Holger Weishaupt, Patrik Johansson, Anders SundstrÃ¶m, Zelmina Lubovac-Pilav, BjÃ¶rn Olsson, Sven Nelander, Fredrik J Swartling
Batch-normalization of cerebellar and medulloblastoma gene expression datasets utilizing empirically defined negative control genes
published pages: 3357-3364, ISSN: 1367-4803, DOI: 10.1093/bioinformatics/btz066
Aldwin Suryo Rahmanto, Vasil Savov, AndrÃ¤ Brunner, Sara Bolin, Holger Weishaupt, Alena Malyukova, Gabriela RosÃ©n, Matko ÄŒanÄer, Sonja Hutter, Anders SundstrÃ¶m, Daisuke Kawauchi, David TW Jones, Charles Spruck, Michael D Taylor, Yoonâ€Jae Cho, Stefan M Pfister, Marcel Kool, Andrey Korshunov, Fredrik J Swartling, Olle Sangfelt
FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma
published pages: 2192-2212, ISSN: 0261-4189, DOI: 10.15252/embj.201693889
|The EMBO Journal 35/20||2019-05-24|
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