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CLOSPORE SIGNED

UNDERSTANDING THE CLOSTRIDIUM SPORE, A PREREQUISTE FOR DISEASE INTERVENTIONS AND EXPLOITATION

Total Cost €

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EC-Contrib. €

0

Partnership

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 CLOSPORE project word cloud

Explore the words cloud of the CLOSPORE project. It provides you a very rough idea of what is the project "CLOSPORE" about.

vegetative    interdisciplinary    whilst    pathogenic    earth    genus    fuels    despite    perfringens    linked    universities    manner    pooling    dormant    intersectorial    fragmented    industrially    foodstuff    intervention    efforts    return    coherence    germination    species    notorious    spores    treating    endospores    infection    heart    deficiency    cells    devastating    intimately    pathogens    toxins    contamination    training    entirely    resistant    poisoning    world    endotoxins    cytotoxins    create    lies    bacterial    societal    diseases    majority    crucially    play    neurotoxins    clostridial    clostridia    producing    clospore    little    pathogenesis    cancer    pivotal    developmental    tackle    leaders    companies    ascribed    botulinum    accordingly    toxin    sporulation    life    spread    regulation    single    spore    sustainably    chemical    points    difficile    facetted    big    forms    clostridium    innovative    capacity    food    benign    chemicals    eg   

Project "CLOSPORE" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF NOTTINGHAM 

Organization address
address: University Park
city: NOTTINGHAM
postcode: NG7 2RD
website: www.nottingham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.clostridia.net/clospore/
 Total cost 3˙910˙777 €
 EC max contribution 3˙910˙777 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2014
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-01-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF NOTTINGHAM UK (NOTTINGHAM) coordinator 819˙863.00
2    HELSINGIN YLIOPISTO FI (HELSINGIN YLIOPISTO) participant 538˙290.00
3    INSTITUT PASTEUR FR (PARIS CEDEX 15) participant 525˙751.00
4    NIZO FOOD RESEARCH BV NL (EDE GLD) participant 510˙748.00
5    PURAC BIOCHEM BV NL (GORINCHEM) participant 510˙748.00
6    UNIVERSIDADE NOVA DE LISBOA PT (LISBOA) participant 476˙712.00
7    Green Biologics Ltd. UK (Abingdon) participant 273˙287.00
8    STICHTING WAGENINGEN RESEARCH NL (WAGENINGEN) participant 255˙374.00
9    INSTITUTO DE TECNOLOGIA QUIMICA E BIOLOGICA - UNIVERSIDADE NOVA DE LISBOA PT (OEIRAS) participant 0.00
10    ASTELLAS PHARMA EUROPE LTD UK (CHERTSEY) partner 0.00
11    Atria Finland Ltd FI (Kuopio) partner 0.00
12    BIOMERIEUX SA FR (Marcy l'Etoile) partner 0.00
13    HKScan Ltd FI (Turku) partner 0.00
14    Ipsen Pharmaceuticals UK (Oxford) partner 0.00
15    LANZATECH UK LTD UK (BRACKNELL) partner 0.00
16    METABOLIC EXPLORER SA FR (SAINT BEAUZIRE) partner 0.00
17    Saarioinen FI (TAMPERE) partner 0.00
18    Snellmanin Lihanjalostus Oy FI (Pietarsaari) partner 0.00

Map

 Project objective

Bacterial endospores are the most resistant life-forms on earth and the most important single feature of the genus Clostridium. Thus, whilst the pathogenesis of its notorious pathogens (C. botulinum, C. perfringens and C. difficile) is ascribed to the devastating toxins produced (neurotoxins, endotoxins and cytotoxins), it is their capacity to produce spores that lies at the heart of the diseases they cause. This is because spores play the pivotal role in the spread of infection (eg, C. difficile) and in foodstuff contamination and food poisoning (eg, C. botulinum and C. perfringens). The processes of spore formation (sporulation) and germination (return of the dormant spore to toxin-producing, vegetative cells), therefore, represent key intervention points. On the other hand, the majority of clostridia are entirely benign and can sustainably produce all manner of useful chemicals and fuels. Crucially, the regulation of chemical production is intimately linked to that of sporulation. Spores of benign species may also be used as a delivery system for treating cancer. Yet, despite the spore’s importance, little is known of the developmental processes of sporulation and germination. This is because research and training efforts on Clostridium spores are fragmented and there is no coherence between researchers working on pathogenic and industrially important species. CLOSPORE will address this deficiency by pooling the resources of Europe’s leading universities, research organisations and companies, to create an intersectorial Research and Training Programme that is multi-facetted, interdisciplinary and focused on clostridial spores. Accordingly, CLOSPORE will produce the innovative, applied research leaders of the future, able to tackle the big societal challenges facing Europe and the world.

 Deliverables

List of deliverables.
Conditionally CDEPTsporulating strain Other 2019-07-30 15:26:45
Final Report Documents, reports 2019-07-30 15:26:45
Final Conference Proceedings Other 2019-07-30 15:26:45
Increased understanding of disease Other 2019-07-30 15:26:45
Characterised sporulation genes Other 2019-07-30 15:26:45
Submission of Doctorate Thesis Other 2019-07-30 15:26:45
Spore regulators common to toxins Other 2019-07-30 15:26:45
Ethics Other 2019-07-30 15:26:45
Promotional material distributed Other 2019-07-30 15:26:45
CLOSPORE website Websites, patent fillings, videos etc. 2019-07-30 15:26:44
Mid-term Conference Other 2019-07-30 15:26:44
New sporulation/germination genes Other 2019-07-30 15:26:44
First ESR scientific presentation Other 2019-07-30 15:26:44
Sporulation Mutants Isolated Other 2019-07-30 15:26:44
ESRs recruited Other 2019-07-30 15:26:45
Decision-making at single cell level Other 2019-07-30 15:26:44
Exemplification of ACE technology Other 2019-07-30 15:26:44
Asporogenous butanol producers Other 2019-07-30 15:26:44
Social Media Established Websites, patent fillings, videos etc. 2019-07-30 15:26:45
Germination Mutants Isolated Other 2019-07-30 15:26:44
Appointment of Supervisory Board Other 2019-07-30 15:26:45
Universal transposon exemplified Other 2019-07-30 15:26:44

Take a look to the deliverables list in detail:  detailed list of CLOSPORE deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Inés C. Cañadas, Daphne Groothuis, Maria Zygouropoulou, Raquel Rodrigues, Nigel P. Minton
RiboCas: A Universal CRISPR-Based Editing Tool for Clostridium
published pages: , ISSN: 2161-5063, DOI: 10.1021/acssynbio.9b00075
ACS Synthetic Biology 2019-08-05
2019 Patrick Ingle, Daphne Groothuis, Peter Rowe, He Huang, Alan Cockayne, Sarah A. Kuehne, Weihong Jiang, Yang Gu, Christopher M. Humphreys, Nigel P. Minton
Generation of a fully erythromycin-sensitive strain of Clostridioides difficile using a novel CRISPR-Cas9 genome editing system
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-44458-y
Scientific Reports 9/1 2019-08-05
2018 Jeroen Girwar Koendjbiharie, Kilian Wiersma, Richard van Kranenburg
Investigating the Central Metabolism of Clostridium thermosuccinogenes
published pages: e00363-18, ISSN: 0099-2240, DOI: 10.1128/AEM.00363-18
Applied and Environmental Microbiology 84/13 2019-07-30
2018 Ioannis Mougiakos, Elleke F Bosma, Joyshree Ganguly, John van der Oost, Richard van Kranenburg
Hijacking CRISPR-Cas for high-throughput bacterial metabolic engineering: advances and prospects
published pages: 146-157, ISSN: 0958-1669, DOI: 10.1016/j.copbio.2018.01.002
Current Opinion in Biotechnology 50 2019-07-30

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