Opendata, web and dolomites


The Algal Microbiome: Friends and Foes

Total Cost €


EC-Contrib. €






 ALFF project word cloud

Explore the words cloud of the ALFF project. It provides you a very rough idea of what is the project "ALFF" about.

worsens    algae    agronomical    worldwide    algal    overarching    biocontrol    successful    devastating    foresees    causing    environment    biotechnology    diseases    shows    taxonomy    improvement    signalling    underpins    pathogenic    multiple    train    cultivation    interaction    microbial    biological    natural    strategies    microbiome    exceptionally    esrs    training    industries    public    critical    freshwater    cultures    technologists    discovery    species    naturally    morphogenesis    symbionts    alff    occurring    biochemical    genomics    sustainable    pharmaceutical    outreach    metabolite    chemical    practices    mostly    mass    15    land    mutualistic    policy    tackles    axenic    bottlenecks    characterise    food    inter    crops    biggest    broad    interdisciplinary    aquatic    ecology    flora    aquaculture    team    identification    intensification    yield    hands    makers    survival    exponentially    microbes    utilisation    marine    multinational    molecular    pathogens    engineering    interactions    superior    theoretical    bacteria    indispensable    profile    scientific    whilst    understand    likewise    simplified    techniques    harnesses   

Project "ALFF" data sheet

The following table provides information about the project.


Organization address
postcode: PA37 1QA

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 3˙710˙595 €
 EC max contribution 3˙710˙595 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2014
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-01-01   to  2018-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
3    UNIVERSITEIT GENT BE (GENT) participant 501˙120.00
4    VIB BE (ZWIJNAARDE - GENT) participant 501˙120.00
6    PROVIRON HOLDING NV BE (HEMIKSEM) participant 250˙560.00
7    UNIVERSITAT KONSTANZ DE (KONSTANZ) participant 249˙216.00
8    A4F ALGAFUEL SA PT (LISBOA) participant 238˙356.00
9    OSTRAVSKA UNIVERZITA CZ (OSTRAVA) participant 232˙422.00
10    APPLIED MATHS NV BE (SINT MARTENS LATEM) participant 167˙040.00
12    Algoteca de Coimbra PT (Coimbra) partner 0.00
14    Bezhin Rosko FR (Santec) partner 0.00
15    BioMarine HK (Hong Kong) partner 0.00
16    CiIMAR-Madeira PT (Funchal) partner 0.00
18    Dynasty Biotechnology Ltd UK (Cambridge) partner 0.00
19    Ecofuel Laboratories CZ (PRAHA) partner 0.00
20    Genomia Management Ltd UK (Midlothian) partner 0.00
21    HORTIMARE BV NL (Heerhugowaard) partner 0.00
22    Limco International GmBH DE (KONSTANZ) partner 0.00
23    MARINE SCOTLAND UK (ABERDEEN) partner 0.00
26    Syngulon BE (Gosselies) partner 0.00
28    UNU-INWEH CA (Hamilton) partner 0.00


 Project objective

Algal aquaculture is developing exponentially worldwide, with multiple applications in the food, chemical and pharmaceutical industries. Current research in algal biotechnology mostly focuses on metabolite discovery, aquaculture yield improvement and engineering bottlenecks. However, agronomical experience shows that controlling the interaction of land crops with mutualistic or pathogenic microbes is most critical to successful production. Likewise, controlling the microbial flora associated with algae (the 'algal microbiome') is emerging as the biggest biological challenge for their increased usage. Bacteria can control the morphogenesis of algae, while others are indispensable to algal survival. Pathogens are causing devastating diseases, the impact of which worsens with the intensification of aquaculture practices. Thus, the overarching aim of ALFF is to train 15 ESRs (researchers and technologists) within a multinational consortium, whilst bringing a scientific step-change in our understanding of these interactions, leading to the development of superior mass algal cultivation and biocontrol strategies. ALFF tackles: 1) the identification, taxonomy and utilisation of naturally-occurring algal symbionts and pathogens; 2) inter- and intra-species signalling and chemical ecology in aquaculture, natural environment and simplified systems (i.e. axenic cultures /- symbionts); 3) and harnesses state of the art genomics, molecular, and biochemical techniques to characterise these interactions. A highly interdisciplinary team underpins an ambitious theoretical, field, hands-on training and research program. With the support of high profile institutions, ALFF foresees an exceptionally broad range of dissemination and outreach initiatives to help policy makers and the general public better understand the opportunities and issues relating to the sustainable use of our aquatic freshwater and marine resources, within and beyond the EU.


List of deliverables.
D9.1 All outreach events delivered as per Section 3.3.1 Other 2019-07-23 16:17:29
D6.4 PhD awarded to all ALFF ESRs Other 2019-07-22 16:50:45
D4.5 [ESR11] Transcriptomic & metabolomic profiling of young Ulva germlings during biofilm formation Other 2019-07-10 15:51:02
Attendance to ALFF courses Other 2019-07-10 15:51:02
D4.3 [ESR10] Bacterial localization, transcriptomic & metabolomic profiling along a salinity gradient Other 2019-07-10 15:51:02
D3.8 [ESR9] Comparison of the data obtained by the mutant-driven approach with data generated my mass spectrometric identification of signalling molecules Other 2019-07-10 15:51:02
D3.9 [ESR9] Mimicking the effects of identified substances on biofilm formation in biofilm growth chambers Documents, reports 2019-07-10 15:51:02
D5.3 [ESR14] effects of bacterial communities on Nannochloropsis pathways Documents, reports 2019-07-10 15:51:02
D5.4 [ESR14] Public release of upgraded ORCAE platform, incl. systems biology tools & all relevant ALFF datasets Websites, patent fillings, videos etc. 2019-07-10 15:51:02
D2.6 [ESR6] Functional study of eukaryotic-bacterial interactions using DNA stable-isotope probing Other 2019-07-10 15:51:02
D2.7 [ESR6] Insights in the ecological/evolutionary principles underlying the assembly & structure of complex microbial communities in Caulerpa Other 2019-07-10 15:51:02
D4.7 [ESR12] Proteomic analysis of Marinobacter–algal cultures Other 2019-07-10 15:51:02
D8.1 Release of ALFF-derived Open Access resources in collaboration with the UNU-INWEH Websites, patent fillings, videos etc. 2019-07-10 15:51:02
D1.2 Integration of transcriptomics and metabolomics to identify Paraphysoderma nutrients requirements [ESR1] and Seminavis robusta / bacteria [ESR2] interactions. Other 2019-07-10 15:51:02
D1.7 [ESR3] Test correlation between Pseudo-nitschzia infections, interrannual variation & toxicity events Other 2019-07-10 15:51:02
D5.6 [ESR15] novel insights into Ectocarpus-Eurychasma interactions and potential effectors Other 2019-07-10 15:51:02
D2.2 [ESR4] Fungal bioassay, transcriptomics and metabolomics of Saccharina and endophyte pathogens Other 2019-07-10 15:51:02
D5.1 [ESR13] strategies for the storage and analysis of temporally- or spatially-resolved metagenomics data. Other 2019-07-10 15:51:02
D7.1 All ESRs to have completed 3 postgraduate courses and attended 1 scientific conference, as per their PCDP Other 2019-07-10 15:51:02
D5.5 [ESR15] Extended ORCAE version with integrated tools for variant (e.g. SNP) analysis Websites, patent fillings, videos etc. 2019-07-10 15:51:02
D1.5 [ESR2] Mechanisms and first applications of bacterial interference compounds on diatom signalling Other 2019-07-10 15:51:02
D3.4 [ESR8] Community composition and chemical nature of biofilms during cultivation of Nannochloropsis and Isochrysis Documents, reports 2019-07-10 15:51:00
Supervisory Board of the network Other 2019-07-10 15:51:01
D4.2 [ESR10] Genome (expected nb: 5) sequencing and annotation of Ectocarpus-associated bacteria Documents, reports 2019-07-10 15:51:01
D4.4 [ESR11] Bioassays on algicidal/beneficial microorganism on development and morphogenesis of Ulva Other 2019-07-10 15:51:01
D2.5 [ESR6] Metagenomic characterization & localization of communities in native and invasive Caulerpa species Documents, reports 2019-07-10 15:51:00
D4.1 [ESR10] List of bacterial species and cultures necessary for E. subulatus acclimation to freshwater Documents, reports 2019-07-10 15:51:00
D3.7 [ESR9] Transposon tagging bacterial mutants failing to induce diatom growth or carbohydrate secretion Other 2019-07-10 15:51:00

Take a look to the deliverables list in detail:  detailed list of ALFF deliverables.


year authors and title journal last update
List of publications.
2018 Emilio Cirri, Wim Vyverman, Georg Pohnert
Biofilm interactions – bacteria modulate sexual reproduction success of the diatom Seminavis robusta
published pages: , ISSN: 0168-6496, DOI: 10.1093/femsec/fiy161
FEMS Microbiology Ecology 2019-07-10
2017 Hetty KleinJan, Christian Jeanthon, Catherine Boyen, Simon M. Dittami
Exploring the Cultivable Ectocarpus Microbiome
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2017.02456
Frontiers in Microbiology 8 2019-07-10
2018 Céline C. Allewaert, Noreen Hiegle, Martina Strittmatter, Reinhoud de Blok, Tiago Guerra, Claire M.M. Gachon, Wim Vyverman
Life history determinants of the susceptibility of the blood alga Haematococcu s to infection by Paraphysoderma sedebokerense (Blastocladiomycota)
published pages: 282-290, ISSN: 2211-9264, DOI: 10.1016/j.algal.2018.02.015
Algal Research 31 2019-07-10
2018 Pedro Murúa, Frithjof C. Küpper, Liliana A. Muñoz, Miriam Bernard, Akira F. Peters
Microspongium alariae in Alaria esculenta: a widely-distributed non-parasitic brown algal endophyte that shows cell modifications within its host
published pages: 343-354, ISSN: 0006-8055, DOI: 10.1515/bot-2017-0095
Botanica Marina 61/4 2019-07-10
2017 Sheng-Shan Wang, Rong-Kuen Chen, Kai-Yi Chen, Chu-Yin Liu, Shu-Min Kao, Chia-Lin Chung
Genetic mapping of the qSBN7 locus, a QTL controlling secondary branch number per panicle in rice
published pages: 340-347, ISSN: 1344-7610, DOI: 10.1270/jsbbs.17007
Breeding Science 67/4 2019-07-10
2018 Joshua C. Stein, Yeisoo Yu, Dario Copetti, Derrick J. Zwickl, Li Zhang, Chengjun Zhang, Kapeel Chougule, Dongying Gao, Aiko Iwata, Jose Luis Goicoechea, Sharon Wei, Jun Wang, Yi Liao, Muhua Wang, Julie Jacquemin, Claude Becker, Dave Kudrna, Jianwei Zhang, Carlos E. M. Londono, Xiang Song, Seunghee Lee, Paul Sanchez, Andrea Zuccolo, Jetty S. S. Ammiraju, Jayson Talag, Ann Danowitz, Luis F. Rivera, Andrea R. Gschwend, Christos Noutsos, Cheng-chieh Wu, Shu-min Kao, Jhih-wun Zeng, Fu-jin Wei, Qiang Zhao, Qi Feng, Moaine El Baidouri, Marie-Christine Carpentier, Eric Lasserre, Richard Cooke, Daniel da Rosa Farias, Luciano Carlos da Maia, Railson S. dos Santos, Kevin G. Nyberg, Kenneth L. McNally, Ramil Mauleon, Nickolai Alexandrov, Jeremy Schmutz, Dave Flowers, Chuanzhu Fan, Detlef Weigel, Kshirod K. Jena, Thomas Wicker, Mingsheng Chen, Bin Han, Robert Henry, Yue-ie C. Hsing, Nori Kurata, Antonio Costa de Oliveira, Olivier Panaud, Scott A. Jackson, Carlos A. Machado, Michael J. Sanderson, Manyuan Long, Doreen Ware, Rod A. Wing
Genomes of 13 domesticated and wild rice relatives highlight genetic conservation, turnover and innovation across the genus Oryza
published pages: 285-296, ISSN: 1061-4036, DOI: 10.1038/s41588-018-0040-0
Nature Genetics 50/2 2019-07-10
2016 Nelzo C. Ereful, Li-Yu Liu, Eric Tsai, Shu-Min Kao, Shalabh Dixit, Ramil Mauleon, Katrina Malabanan, Michael Thomson, Antonio Laurena, David Lee, Ian Mackay, Andy Greenland, Wayne Powell, Hei Leung
Analysis of Allelic Imbalance in Rice Hybrids Under Water Stress and Association of Asymmetrically Expressed Genes with Drought-Response QTLs
published pages: , ISSN: 1939-8425, DOI: 10.1186/s12284-016-0123-4
Rice 9/1 2019-07-10
2018 Olivier De Clerck, Shu-Min Kao, Kenny A. Bogaert, Jonas Blomme, Fatima Foflonker, Michiel Kwantes, Emmelien Vancaester, Lisa Vanderstraeten, Eylem Aydogdu, Jens Boesger, Gianmaria Califano, Benedicte Charrier, Rachel Clewes, Andrea Del Cortona, Sofie D’Hondt, Noe Fernandez-Pozo, Claire M. Gachon, Marc Hanikenne, Linda Lattermann, Frederik Leliaert, Xiaojie Liu, Christine A. Maggs, Zoë A. Popper, John A. Raven, Michiel Van Bel, Per K.I. Wilhelmsson, Debashish Bhattacharya, Juliet C. Coates, Stefan A. Rensing, Dominique Van Der Straeten, Assaf Vardi, Lieven Sterck, Klaas Vandepoele, Yves Van de Peer, Thomas Wichard, John H. Bothwell
Insights into the Evolution of Multicellularity from the Sea Lettuce Genome
published pages: 2921-2933.e5, ISSN: 0960-9822, DOI: 10.1016/j.cub.2018.08.015
Current Biology 28/18 2019-07-10
2018 Kessler, Ralf W.; Weiss, Anne; Kuegler, Stefan; Hermes, Cornelia; Wichard, Thomas
Macroalgal-bacterial interactions: Role of dimethylsulfoniopropionate in microbial gardening by Ulva (Chlorophyta)
published pages: , ISSN: 1365-294X, DOI: 10.5281/zenodo.2580629
Molecular Ecology 2 2019-07-10
2019 Simon M Dittami​, Enrique Arboleda, Jean-Christophe Auguet, Arite Bigalke, Enora Briand, Paco Cárdenas, Ulisse Cardini, Johan Decelle, Aschwin Engelen, Damien Eveillard, Claire M.M. Gachon, Sarah Griffiths, Tilmann Harder, Ehsan Kayal, Elena Kazamia, François H Lallier, Mónica Media, Ezequiel M. Marzinelli, Teresa Morganti, Laura Núñez Pons, Soizic Prado, José Pintado, Mahasweta Saha, Marc-André Selosse, Derek Skillings, Willem Stock, Shinichi Sunagawa, Eve Toulza, Alexey Vorobev, Catherine Leblanc​, Fabrice Not
A community perspective on the concept of marine holobionts: state-of-the-art, challenges, and future directions
published pages: , ISSN: 2167-8359, DOI: 10.7287/peerj.preprints.27519v1
Peer J 2019-07-10
2019 Frederike Stock, Michail Syrpas, Shiri Graff van Creveld, Simon Backx, Lander Blommaert, Lachlan Dow, Willem Stock, Ewout Ruysbergh, Bernard Lepetit, Benjamin Bailleul, Koen Sabbe, Norbert De Kimpe, Anne Willems, Peter G. Kroth, Assaf Vardi, Wim Vyverman, Sven Mangelinckx
N -Acyl Homoserine Lactone Derived Tetramic Acids Impair Photosynthesis in Phaeodactylum tricornutum
published pages: 198-203, ISSN: 1554-8929, DOI: 10.1021/acschembio.8b01101
ACS Chemical Biology 14/2 2019-07-10
2018 Andrea Garvetto, Elisabeth Nézan, Yacine Badis, Gwenael Bilien, Paola Arce, Eileen Bresnan, Claire M. M. Gachon, Raffaele Siano
Novel Widespread Marine Oomycetes Parasitising Diatoms, Including the Toxic Genus Pseudo-nitzschia: Genetic, Morphological, and Ecological Characterisation
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2018.02918
Frontiers in Microbiology 9 2019-07-10
2017 Taghreed Alsufyani, Anne Weiss, Thomas Wichard
Time Course Exo-Metabolomic Profiling in the Green Marine Macroalga Ulva (Chlorophyta) for Identification of Growth Phase-Dependent Biomarkers
published pages: 14, ISSN: 1660-3397, DOI: 10.3390/md15010014
Marine Drugs 15/1 2019-07-10
2018 Cecilia Rad-Menéndez, Mélanie Gerphagnon, Andrea Garvetto, Paola Arce, Yacine Badis, Télesphore Sime-Ngando, Claire M. M. Gachon
Rediscovering Zygorhizidium affluens Canter: Molecular Taxonomy, Infectious Cycle, and Cryopreservation of a Chytrid Infecting the Bloom-Forming Diatom Asterionella formosa
published pages: , ISSN: 0099-2240, DOI: 10.1128/aem.01826-18
Applied and Environmental Microbiology 84/23 2019-07-10
2019 Tereza Ševčíková, Tatiana Yurchenko, Karen P Fawley, Raquel Amaral, Hynek Strnad, Lilia M A Santos, Marvin W Fawley, Marek Eliáš
Plastid Genomes and Proteins Illuminate the Evolution of Eustigmatophyte Algae and Their Bacterial Endosymbionts
published pages: 362-379, ISSN: 1759-6653, DOI: 10.1093/gbe/evz004
Genome Biology and Evolution 11/2 2019-07-10
2018 Miriam Bernard, Sylvie Rousvoal, Bertrand Jacquemin, Marion Ballenghien, Akira F. Peters, Catherine Leblanc
qPCR-based relative quantification of the brown algal endophyte Laminarionema elsbetiae in Saccharina latissima: variation and dynamics of host—endophyte interactions
published pages: 2901-2911, ISSN: 0921-8971, DOI: 10.1007/s10811-017-1367-0
Journal of Applied Phycology 30/5 2019-07-10
2016 Thomas Wichard
Identification of Metallophores and Organic Ligands in the Chemosphere of the Marine Macroalga Ulva (Chlorophyta) and at Land-Sea Interfaces
published pages: , ISSN: 2296-7745, DOI: 10.3389/fmars.2016.00131
Frontiers in Marine Science 3 2019-07-10
2018 Yacine Badis, Tatyana A. Klochkova, Martina Strittmatter, Andrea Garvetto, Pedro Murúa, J. Craig Sanderson, Gwang Hoon Kim, Claire M. M. Gachon
Novel species of the oomycete Olpidiopsis potentially threaten European red algal cultivation
published pages: , ISSN: 0921-8971, DOI: 10.1007/s10811-018-1641-9
Journal of Applied Phycology 2019-07-10
2018 Tatiana Yurchenko, Tereza Ševčíková, Pavel Přibyl, Khalid El Karkouri, Vladimír Klimeš, Raquel Amaral, Veronika Zbránková, Eunsoo Kim, Didier Raoult, Lilia M. A. Santos, Marek Eliáš
A gene transfer event suggests a long-term partnership between eustigmatophyte algae and a novel lineage of endosymbiotic bacteria
published pages: 2163-2175, ISSN: 1751-7362, DOI: 10.1038/s41396-018-0177-y
The ISME Journal 12/9 2019-07-10
2018 Miriam S. Bernard, Martina Strittmatter, Pedro Murúa, Svenja Heesch, Ga Youn Cho, Catherine Leblanc, Akira F. Peters
Diversity, biogeography and host specificity of kelp endophytes with a focus on the genera Laminarionema and Laminariocolax (Ectocarpales, Phaeophyceae)
published pages: 39-51, ISSN: 0967-0262, DOI: 10.1080/09670262.2018.1502816
European Journal of Phycology 54/1 2019-07-10
2016 Emilio Cirri, Katharina Grosser, Georg Pohnert
A solid phase extraction based non-disruptive sampling technique to investigate the surface chemistry of macroalgae
published pages: 145-153, ISSN: 0892-7014, DOI: 10.1080/08927014.2015.1130823
Biofouling 32/2 2019-07-10
2016 Tatiana Yurchenko, Tereza Ševčíková, Hynek Strnad, Anzhelika Butenko, Marek Eliáš
The plastid genome of some eustigmatophyte algae harbours a bacteria-derived six-gene cluster for biosynthesis of a novel secondary metabolite
published pages: 160249, ISSN: 2046-2441, DOI: 10.1098/rsob.160249
Open Biology 6/11 2019-07-10
2018 C Kuhlisch, G Califano, T Wichard, G Pohnert
Metabolomics ofintra- and extracellular metabolites from micro- and macroalgae using GC-MS and LC-MS
published pages: , ISSN: , DOI: 10.5281/zenodo.2578249
Protocols for Macroalgae Research 2019-07-10
2018 Gianmaria Califano, Thomas Wichard
Preparation of axenic cultures in Ulva (Chlorophyta)
published pages: , ISSN: , DOI: 10.5281/zenodo.2578236
Protocols for Macroalgae Research 2019-07-10

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