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MetaRNA

RNA-based technologies for single-cell metabolite analysis

Total Cost €

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EC-Contrib. €

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Partnership

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Project "MetaRNA" data sheet

The following table provides information about the project.

Coordinator
RIJKSUNIVERSITEIT GRONINGEN 

Organization address
address: Broerstraat 5
city: GRONINGEN
postcode: 9712CP
website: www.rug.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://www.metarna.eu
 Total cost 3˙995˙643 €
 EC max contribution 3˙995˙643 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2014
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-01-01   to  2019-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RIJKSUNIVERSITEIT GRONINGEN NL (GRONINGEN) coordinator 510˙748.00
2    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) participant 580˙163.00
3    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 525˙751.00
4    RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN DE (BONN) participant 498˙432.00
5    TECHNISCHE UNIVERSITAT DARMSTADT DE (DARMSTADT) participant 498˙432.00
6    BIOSYNTIA APS DK (HORSHOLM) participant 290˙081.00
7    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 290˙081.00
8    THE UNIVERSITY OF WARWICK UK (COVENTRY) participant 273˙287.00
9    DSM FOOD SPECIALTIES BV NL (DELFT) participant 255˙374.00
10    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) participant 250˙513.00
11    MEDICAL RESEARCH COUNCIL UK (SWINDON) participant 22˙773.00
12    APTAIT GMBH DE (DIESSEN) partner 0.00
13    ASSOCIATION POUR LE DEVELOPPEMENT DE L'ENSEIGNEMENT ET DES RECHERCHES AUPRES DES UNIVERSITES, DES CENTRES DE RECHERCHE ET DES ENTREPRISES D'AQUITAINE FR (PESSAC) partner 0.00
14    EVOLVA AG CH (REINACH) partner 0.00
15    TPP Global Development UK (Edinburgh) partner 0.00

Map

 Project objective

Metabolism is the foundation of all living organisms. While cells in a population are often phenotypically different, most of our current analytical approaches still probe metabolism only at the population level. Because strong evidence exists that metabolic cell-to-cell heterogeneity has, for instance, disease relevance, researcher from MetaRNA will overcome this severe analytical limitation through exploiting exciting opportunities emerging from the RNA field. Such synergy potential between the metabolism and RNA research fields has until today not been exploited, because they are separated from each other in Europe and worldwide. Through consequently missing research training programs we thus lack experts with combined knowledge in metabolism and RNA. The aim of the MetaRNA proposal is therefore to establish a European Training Network (ETN) that educates specialists for academia and industry - fully trained at the interface of these two fields - in the development and application of RNA-based sensors to investigate metabolism at the single-cell level, to apply these tools for novel biotechnological applications and to provide a framework for their future use in diagnostics and therapeutics. In MetaRNA, eight research groups from the metabolic and RNA fields and six partners from the private sector join forces to create a platform of mobility and training to 15 early-stage researchers (ESRs), by means of customized research projects, exchange of knowhow among researchers and partners, attendance to specialized courses, workshops and conferences, as well as training in complementary skills.

 Deliverables

List of deliverables.
Secondary structure of aptamers in vivo Documents, reports 2020-02-20 11:28:45
Fluxes through the yeast cell cycle quantified Documents, reports 2020-02-20 11:28:46
Methodology to optimize RNA-based sensors Documents, reports 2020-02-20 11:28:46
Highest producing E.coli strains Other 2020-02-20 11:28:45
Cellular and in vivo delivery of RNA-based sensor Documents, reports 2020-02-20 11:28:45
Characterisation of normal liver & liver tumour metabolic heterogeneity Documents, reports 2020-02-20 11:28:45
Highest producing yeast strains Other 2020-02-20 11:28:45
Optimized RNA-based sensor Documents, reports 2020-02-20 11:28:46
Test of application of titratable RNA-based sensor Other 2020-02-20 11:28:46
Elucidation of population wide production heterogeneity on the single cell level Documents, reports 2020-02-20 11:28:45
Quantitative MS and IMS Documents, reports 2020-02-20 11:28:46
Adenoviral vectors Documents, reports 2020-02-20 11:28:44
First flux-sensor validated Documents, reports 2020-02-20 11:28:44
In vivo screening system Demonstrators, pilots, prototypes 2020-02-20 11:28:44
RNA-based metabolite sensor Documents, reports 2020-02-20 11:28:44
First aptamers identified Documents, reports 2020-02-20 11:28:44
RNA-based sensor for thiamine or coumarate Documents, reports 2020-02-20 11:28:44
Novel SELEX method Documents, reports 2020-02-20 11:28:44
Scientific courses Other 2020-02-20 11:28:44
First flux-signaling metabolites identified Documents, reports 2020-02-20 11:28:44
Project website Websites, patent fillings, videos etc. 2020-02-20 11:28:44
Transferable skills courses Other 2020-02-20 11:28:45

Take a look to the deliverables list in detail:  detailed list of MetaRNA deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Adrien Boussebayle, Florian Groher, Beatrix Suess
RNA-based Capture-SELEX for the selection of small molecule-binding aptamers
published pages: 10-15, ISSN: 1046-2023, DOI: 10.1016/j.ymeth.2019.04.004
Methods 161 2020-02-20
2019 Adrien Boussebayle, Florian Groher, Beatrix Suess
RNA-based Capture-SELEX for the selection of small molecule-binding aptamers
published pages: 10-15, ISSN: 1046-2023, DOI: 10.1016/j.ymeth.2019.04.004
Methods 161 2020-02-20
2018 Vakil Takhaveev, Matthias Heinemann
Metabolic heterogeneity in clonal microbial populations
published pages: 30-38, ISSN: 1369-5274, DOI: 10.1016/j.mib.2018.02.004
Current Opinion in Microbiology 45 2020-02-20
2018 Louise Fets, Paul C. Driscoll, Fiona Grimm, Aakriti Jain, Patrícia M. Nunes, Michalis Gounis, Ginevra Doglioni, George Papageorgiou, Timothy J. Ragan, Sebastien Campos, Mariana Silva dos Santos, James I. MacRae, Nicola O’Reilly, Alan J. Wright, Cyril H. Benes, Kevin D. Courtney, David House, Dimitrios Anastasiou
MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG
published pages: 1032-1042, ISSN: 1552-4450, DOI: 10.1038/s41589-018-0136-y
Nature Chemical Biology 14/11 2020-02-20
2019 Adrien Boussebayle, Daniel Torka, Sandra Ollivaud, Johannes Braun, Cristina Bofill-Bosch, Max Dombrowski, Florian Groher, Kay Hamacher, Beatrix Suess
Next-level riboswitch development—implementation of Capture-SELEX facilitates identification of a new synthetic riboswitch
published pages: 4883-4895, ISSN: 0305-1048, DOI: 10.1093/nar/gkz216
Nucleic Acids Research 47/9 2020-02-20
2019 Josi Buerger, Luisa S. Gronenberg, Hans Jasper Genee, Morten O.A. Sommer
Wiring cell growth to product formation
published pages: 85-92, ISSN: 0958-1669, DOI: 10.1016/j.copbio.2019.02.014
Current Opinion in Biotechnology 59 2020-02-20
2017 Leonie J. Jahn, Christian Munck, Mostafa M. H. Ellabaan, Morten O. A. Sommer
Adaptive Laboratory Evolution of Antibiotic Resistance Using Different Selection Regimes Lead to Similar Phenotypes and Genotypes
published pages: , ISSN: 1664-302X, DOI: 10.3389/fmicb.2017.00816
Frontiers in Microbiology 8 2020-02-20
2018 Leonie Johanna Jahn, Andreas Porse, Christian Munck, Daniel Simon, Svetlana Volkova, Morten Otto Alexander Sommer
Chromosomal barcoding as a tool for multiplexed phenotypic characterization of laboratory evolved lineages
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-25201-5
Scientific Reports 8/1 2020-02-20
2019 Simeon Leupold, Georg Hubmann, Athanasios Litsios, Anne C Meinema, Vakil Takhaveev, Alexandros Papagiannakis, Bastian Niebel, Georges Janssens, David Siegel, Matthias Heinemann
Saccharomyces cerevisiae goes through distinct metabolic phases during its replicative lifespan
published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.41046
eLife 8 2020-02-20
2019 Sara Masachis, Nicolas J Tourasse, Claire Lays, Marion Faucher, Sandrine Chabas, Isabelle Iost, Fabien Darfeuille
A genetic selection reveals functional metastable structures embedded in a toxin-encoding mRNA
published pages: , ISSN: , DOI: 10.1101/615682
Bioxriv 2020-02-20
2017 Danny Filer, Maximillian A. Thompson, Vakil Takhaveev, Adam J. Dobson, Ilektra Kotronaki, James W. M. Green, Matthias Heinemann, Jennifer M. A. Tullet, Nazif Alic
RNA polymerase III limits longevity downstream of TORC1
published pages: 263-267, ISSN: 0028-0836, DOI: 10.1038/nature25007
Nature 552/7684 2020-02-20
2019 Stefan Breuers, Laura Lledo Bryant, Tjasa Legen, Günter Mayer
Robotic assisted generation of 2′-deoxy-2′-fluoro-modifed RNA aptamers – High performance enabling strategies in aptamer selection
published pages: 3-9, ISSN: 1046-2023, DOI: 10.1016/j.ymeth.2019.05.022
Methods 161 2020-02-20
2016 Dimitrios Anastasiou
Tumour microenvironment factors shaping the cancer metabolism landscape
published pages: 277-286, ISSN: 0007-0920, DOI: 10.1038/bjc.2016.412
British Journal of Cancer 116/3 2020-02-20
2016 Manish Kushwaha, William Rostain, Satya Prakash, John N. Duncan, Alfonso Jaramillo
Using RNA as Molecular Code for Programming Cellular Function
published pages: 795-809, ISSN: 2161-5063, DOI: 10.1021/acssynbio.5b00297
ACS Synthetic Biology 5/8 2020-02-20
2017 Hélène Arnion, Dursun Nizam Korkut, Sara Masachis Gelo, Sandrine Chabas, Jérémy Reignier, Isabelle Iost, Fabien Darfeuille
Mechanistic insights into type I toxin antitoxin systems in Helicobacter pylori: the importance of mRNA folding in controlling toxin expression
published pages: gkw1343, ISSN: 0305-1048, DOI: 10.1093/nar/gkw1343
Nucleic Acids Research 2020-02-20

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