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MATRIXASSAY

Novel Cell Migration Assay Based on Microtissue Technology and Tissue-Specific Matrices

Total Cost €

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EC-Contrib. €

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Partnership

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Project "MATRIXASSAY" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN 

Organization address
address: BELFIELD
city: DUBLIN
postcode: 4
website: www.ucd.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website http://www.ucd.ie/matrixassay/
 Total cost 1˙053˙000 €
 EC max contribution 931˙500 € (88%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2014
 Funding Scheme MSCA-RISE
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2019-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN IE (DUBLIN) coordinator 216˙000.00
2    LOUGHBOROUGH UNIVERSITY UK (LOUGHBOROUGH) participant 324˙000.00
3    ABERYSTWYTH UNIVERSITY UK (ABERYSTWYTH) participant 310˙500.00
4    BLAFAR LIMITED IE (BLACKROCK DUBLIN) participant 40˙500.00
5    MSC.SOFTWARE LTD. UK (FRIMLEY, CAMBERLEY SURREY) participant 27˙000.00
6    ASHLAND SPECIALTIES IRELAND LIMITED IE (Dublin) participant 13˙500.00
7    FIBRALIGN CORPORATION US (UNION CITY CA) partner 0.00
8    GRIFFITH UNIVERSITY AU (BRISBANE) partner 0.00
9    INSPHERO AG CH (SCHLIEREN) partner 0.00
10    THE UNIVERSITY OF TEXAS SYSTEM US (AUSTIN) partner 0.00

Map

 Project objective

Cell migration assays are commonly used to study wound healing, cancer cell invasion, and tissue development. Problems associated with the gap closure assays typically employed are that: (i) the stopper or scratch used to make the migration zone damages the extracellular matrix (ECM), (ii) the migration zone size is limited by the size of the stopper, and (iii) the scratched migration zone shapes and sizes are irreproducible. Cell migration is strongly coupled with the structure and mechanical properties of the ECM, and damage to the ECM alters the cell migration path.

The main objective of this project is to develop a prototype novel cell migration assay, which will significantly improve the predictive power of cell-based assays while avoiding problems associated with existing assays, based on seeding cells precisely on pristine extracellular matrix tissue mimics with native-like cell-functionality and reproducible migration zones.

In accomplishing this, we will also address the following questions: • What are the structure-property relationships between collagen I matrices with controlled thicknesses and fibril diameter and alignment, and their mechanical and electromechanical properties? • What are the critical parameters for achieving functional bonding between the substrate and the highly anisotropic viscoelastic collagen I matrices and controlling the overall mechanical properties? • Does the distribution of collagen fibril polar ordering, i.e., piezoelectric domains, influence cell migration? • What parameters control crimp formation in tendon-like collagen I matrices? • What parameters control and explain the unusual viscoelastic properties (e.g., they not depend on the speed of deformation, at least within the interval 0.01 - 1 mm/sec) of tendon-like collagen matrices? • Which cell types, including cancer cells, co-align with collagen fibril alignment or crimp direction?

 Deliverables

List of deliverables.
Yearly report on scientific and technical progress 3 Documents, reports 2020-02-06 16:17:12
Yearly report & management of next year’s outreach activities 3 Documents, reports 2020-02-06 16:17:12
Abstracts of the workshop Documents, reports 2020-02-06 16:17:11
Yearly report on scientific and technical progress 1 Documents, reports 2020-02-06 16:17:11
Yearly report & management of next year’s outreach activities 1 Documents, reports 2020-02-06 16:17:11
Yearly report & management of next year’s outreach activities 2 Documents, reports 2020-02-06 16:17:12
Yearly report on scientific and technical progress 2 Documents, reports 2020-02-06 16:17:12

Take a look to the deliverables list in detail:  detailed list of MATRIXASSAY deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Sawsan Almohammed, Maha Alruwaili, Emmanuel G. Reynaud, Gareth Redmond, James H. Rice, Brian J. Rodriguez
3D-Printed Peptide-Hydrogel Nanoparticle Composites for Surface-Enhanced Raman Spectroscopy Sensing
published pages: , ISSN: 2574-0970, DOI: 10.1021/acsanm.9b00940
ACS Applied Nano Materials 2020-02-06
2019 Sawsan Almohammed, Fengyuan Zhang, Brian J. Rodriguez, James H. Rice
Electric Field-Induced Chemical Surface-Enhanced Raman Spectroscopy Enhancement from Aligned Peptide Nanotube–Graphene Oxide Templates for Universal Trace Detection of Biomolecules
published pages: 1878-1887, ISSN: 1948-7185, DOI: 10.1021/acs.jpclett.9b00436
The Journal of Physical Chemistry Letters 10/8 2020-02-06
2019 Sawsan Almohammed, Brian J. Rodriguez, James H. Rice
Nucleobase sensing using highly-sensitive surface-enhanced Raman spectroscopy templates comprising organic semiconductor peptide nanotubes and metal nanoparticles
published pages: 100287, ISSN: 2214-1804, DOI: 10.1016/j.sbsr.2019.100287
Sensing and Bio-Sensing Research 24 2020-02-06
2019 Maha Alruwaili, Jose A. Lopez, Kevin McCarthy, Emmanuel G. Reynaud, Brian J. Rodriguez
Liquid-phase 3D bioprinting of gelatin alginate hydrogels: influence of printing parameters on hydrogel line width and layer height
published pages: , ISSN: 2096-5524, DOI: 10.1007/s42242-019-00043-w
Bio-Design and Manufacturing 2020-02-06
2019 RICCARDO MOLINAROLO
EXISTENCE OF SOLUTIONS FOR A SINGULARLYPERTURBED NONLINEAR NON-AUTONOMOUSTRANSMISSION PROBLEM
published pages: 1–29, ISSN: 1072-6691, DOI:
Electronic Journal of Differential Equations Vol. 2019 (2019), No. 53, pp. 1 2020-02-06
2018 Daniel Peck, Michal Wrobel, Monika Perkowska, Gennady Mishuris
Fluid velocity based simulation of hydraulic fracture: a penny shaped model—part I: the numerical algorithm
published pages: 3615-3635, ISSN: 0025-6455, DOI: 10.1007/s11012-018-0899-y
Meccanica 53/15 2020-02-06
2018 Emrah Sozumert, Farukh Farukh, Baris Sabuncuoglu, Emrah Demirci, Memis Acar, Behnam Pourdeyhimi, Vadim V. Silberschmidt
Deformation and damage of random fibrous networks
published pages: , ISSN: 0020-7683, DOI: 10.1016/j.ijsolstr.2018.12.012
International Journal of Solids and Structures 2020-02-06
2018 Sawsan Almohammed, Fengyuan Zhang, Brian J. Rodriguez, James H. Rice
Photo-induced surface-enhanced Raman spectroscopy from a diphenylalanine peptide nanotube-metal nanoparticle template
published pages: 3880, ISSN: 2045-2322, DOI: 10.1038/s41598-018-22269-x
Scientific Reports 8/1 2020-02-06
2017 Davies, I. T.
Simulating the interaction between a falling super-quadric object and a soap film
published pages: , ISSN: , DOI:
1 2020-02-06
2016 Sergei Rogosin, Gennady Mishuris, Anna Koroleva, Anastasiya Vinakurava
ANALYSIS OF THE UNILATERAL CONTACT PROBLEM FOR BIPHASIC CARTILAGE LAYERS WITH AN ELLIPTIC CONTACT ZONE AND ACCOUNTING FOR TANGENTIAL DISPLACEMENTS
published pages: 585-609, ISSN: 1392-6292, DOI: 10.3846/13926292.2016.1196249
Mathematical Modelling and Analysis 21/5 2020-02-06
2018 F. Zaccagnino, A. Audebert, S. J. Cox
Simulation of surfactant transport during the rheological relaxation of two-dimensional dry foams
published pages: , ISSN: 2470-0045, DOI: 10.1103/PhysRevE.98.022801
Physical Review E 98/2 2020-02-06
2017 Gennaro Vitucci, Gennady Mishuris
Three-dimensional contact of transversely isotropic transversely homogeneous cartilage layers: A closed-form solution
published pages: 195-204, ISSN: 0997-7538, DOI: 10.1016/j.euromechsol.2017.04.004
European Journal of Mechanics - A/Solids 65 2020-02-06
2017 Teixeira, Miguel; Arscott, Steve; Cox, Simon; Teixeira, Paulo Ivo Cortez
When is a surface foam-phobic?
published pages: , ISSN: , DOI:
TEIXEIRA, Miguel [et al] – When is a surface foam-phobic?. In 10th Liquid Matter Conference, Ljubljana Slovenia, 2017. 1 2020-02-06
2018 Liam Collins, Stefan A.L. Weber, Brian J. Rodriguez
Applications of KPFM-Based Approaches for Surface Potential and Electrochemical Measurements in Liquid
published pages: 391-433, ISSN: , DOI: 10.1007/978-3-319-75687-5_13
2020-02-06
2018 Liam Collins, Jason I Kilpatrick, Sergei V Kalinin, Brian J Rodriguez
Towards nanoscale electrical measurements in liquid by advanced KPFM techniques: a review
published pages: 86101, ISSN: 0034-4885, DOI: 10.1088/1361-6633/aab560
Reports on Progress in Physics 81/8 2020-02-06
2017 Arwa Bazaid, Sabine M Neumayer, Anna Sorushanova, Jill Guyonnet, Dimitrios Zeugolis, Brian J Rodriguez
Non-destructive determination of collagen fibril width in extruded collagen fibres by piezoresponse force microscopy
published pages: 55004, ISSN: 2057-1976, DOI: 10.1088/2057-1976/aa85ec
Biomedical Physics & Engineering Express 3/5 2020-02-06
2019 Sawsan Almohammed, Sebastian Tade Barwich, Andrew K. Mitchell, Brian J. Rodriguez, James H. Rice
Enhanced photocatalysis and biomolecular sensing with field-activated nanotube-nanoparticle templates
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-10393-9
Nature Communications 10/1 2020-02-06
2017 Denise Denning, Jason I Kilpatrick, Eiichi Fukada, Nan Zhang, Stefan Habelitz, Andrzej Fertala, Michael Gilchrist, Yuqi Zhang, Syed A. M. Tofail, Brian J. Rodriguez
The piezoelectric tensor of collagen fibrils determined at the nanoscale
published pages: 929-935, ISSN: 2373-9878, DOI: 10.1021/acsbiomaterials.7b00183
ACS Biomaterials Science & Engineering 3 2020-02-06
2016 I. Argatov and G. Mishuris
Articular Contact Mechanics from an Asymptotic Modeling Perspective: A Review
published pages: 83: 1-9, ISSN: 2296-4185, DOI: 10.3389/fbioe.2016.00083
Front. Bioeng. Biotechnol. 4 2020-02-06
2018 Daniel Peck, Michal Wrobel, Monika Perkowska, Gennady Mishuris
Fluid velocity based simulation of hydraulic fracture: a penny shaped model—part I: the numerical algorithm
published pages: 3615-3635, ISSN: 0025-6455, DOI: 10.1007/s11012-018-0899-y
Meccanica 53/15 2020-02-06
2016 G. Vitucci, I. Argatov, G. Mishuris
An asymptotic model for the deformation of a transversely isotropic, transversely homogeneous biphasic cartilage layer
published pages: n/a-n/a, ISSN: 0170-4214, DOI: 10.1002/mma.3895
Mathematical Methods in the Applied Sciences 28 FEB 2016 2020-02-06
2017 S J Cox, F Graner, R Mosseri and J-F Sadoc
Quasicrystalline three-dimensional foams
published pages: 114001- 114010, ISSN: 0953-8984, DOI: 10.1088/1361-648X/aa5712
Journal of Physics: Condensed Matter 29 2020-02-06
2016 Ivan Argatov, Gennady Mishuris
Pipette aspiration testing of soft tissues: the elastic half-space model revisited
published pages: 20160559, ISSN: 1364-5021, DOI: 10.1098/rspa.2016.0559
Proceedings of the Royal Society A: Mathematical, Physical and Engineering Science 472/2193 2020-02-06
2016 I. I. Argatov, G. S. Mishuris, V. L. Popov
An Approximate JKR Model of Elliptical Contact Between Thin Incompressible Elastic Coatings Covering Rigid Cylinders
published pages: , ISSN: 1023-8883, DOI: 10.1007/s11249-016-0746-z
Tribology Letters 64/1 2020-02-06

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