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KCs and Gut Antigens

Elucidating the role of liver resident Kupffer cells in the regulation of the immune responses to intestinal antigens

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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Project "KCs and Gut Antigens" data sheet

The following table provides information about the project.

Coordinator
VIB 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Project website http://www.irc.ugent.be/index.php
 Total cost 160˙800 €
 EC max contribution 160˙800 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2017-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB BE (ZWIJNAARDE - GENT) coordinator 160˙800.00

Map

 Project objective

The liver is constantly exposed to intestinal material via portal blood circulation and thus it has long been implicated in the modulation of systemic immune responses to intestinal antigens. Despite this, the precise cells involved and the molecular mechanisms at play are largely unknown. Liver resident macrophages termed Kupffer cells (KCs) are ideally located within the blood stream of the liver sinusoids to encounter intestinal antigens. We hypothesise that KCs acquire intestinal antigens and subsequently modulate the immune response to these. Despite indications that KCs are involved, the lack of KC-specific tools has significantly hampered the study of these cells and to date their physiological role in modulating immune responses to intestinal antigens remains unclear. Here we propose to utilize novel and innovative tools including KC-specific knock-in (KI) mice generated by the host lab to specifically examine the role of KCs in antigen acquisition, presentation and determination of T cell fate. To our knowledge these tools represent the first of their kind and place us in a unique position to specifically examine the role of KCs in regulating the immune response to intestinal antigens. By combining murine modeling with analysis of human tissues in collaboration with the University Hospital, this project will greatly advance our understanding of the role of KCs and potentially uncover new therapeutic strategies in the prevention and/or treatment of disorders where the systemic immune response to intestinal antigens is dysregulated such as food allergies and inflammatory bowel diseases (IBDs).

 Publications

year authors and title journal last update
List of publications.
2016 Charlotte L. Scott, Fang Zheng, Patrick De Baetselier, Liesbet Martens, Yvan Saeys, Sofie De Prijck, Saskia Lippens, Chloé Abels, Steve Schoonooghe, Geert Raes, Nick Devoogdt, Bart N. Lambrecht, Alain Beschin, Martin Guilliams
Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells
published pages: 10321, ISSN: 2041-1723, DOI: 10.1038/ncomms10321
Nature Communications 7 2019-07-24
2017 M Guilliams and CL Scott
Does Niche competition determine the origin of tissue-resident macrophages?
published pages: , ISSN: 1474-1733, DOI:
Nature Reviews Immunology 2019-07-24
2016 Scott CL*, Soen B*, Martens L, Skrypek N, Saelens W, Taminau J, Blancke G, Van Isterdael G, Huylebroeck D, Haigh J, Saeys Y, Guilliams M, Lambrecht BN, Berx G.
The transcription factor Zeb2 regulates the development of conventional and plasmacytoid DCs by repressing Id2
published pages: , ISSN: 0022-1007, DOI:
Journal of Experimental Medicine 2019-07-24
2017 D Sichien, BN Lambrecht, M Guilliams & CL Scott
Development of conventional dendritic cells: from common bone marrow progenitors to multiple subsets in peripheral tissues
published pages: , ISSN: 1933-0219, DOI:
Mucosal Immunology 2019-07-24
2016 Guilliams M*, Dutertre CA*, Scott CL*, McGovern N*, Sichien D*, Chakarov S, Van Gassen S, Chen J, Poidinger M, De Prijck S, Low I, Irac SE, Nurfarah Mattar C, Rizal Sumatoh H, Hui Ling Low G, Kit Chung TJ, Kok Hong Chan D, Kan Tan K, Lim Kiat Hon T, Fossum E, Bogen B, Choolani M, Kok Yen Chan J, Larbi A, Luche H, Henri S, Saeys Y, Newell EW, Lambrecht BN, Malissen B and Ginhoux F.
Unsupervised high dimensional analysis aligns dendritic cells across tissues and species.
published pages: , ISSN: 1074-7613, DOI:
Immunity 2019-07-24

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