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PRISAR

Preclinical Intra-Operative Image-Guided Surgery and Post-Operative Radiotherapy of Tumours

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

PRISAR project word cloud

Explore the words cloud of the PRISAR project. It provides you a very rough idea of what is the project "PRISAR" about.

rates deep post tumour margin intervention stay guided peptide entity patients twelve postoperative near surgical clinical consequence definitive lowering health revolutionary countries fluorescent revolves survival quality molecular training hybrid camera validate patient tissues technologists detection hypothesis cancer probe risk life dye resection minimised infra tissue reference imaging radiotherapy disciplinary radionuclide levels recurrence clinicians endoscopic oncology residual subcellular construct accelerate inter image surgery nirf hospital benefits therapeutic conjugated implementing removal surgeons red healthy probes operative scientists morbidity detect technologies antigen macroscopic remaining handheld fluorescence optoacoustic basic combination serve mobility synthesis cellular cross

Project "PRISAR" data sheet

The following table provides information about the project.

Coordinator	PERCUROS BV Organization address address: PLESMANLAAN 1 city: LEIDEN postcode: 2333 BZ website: www.percuros.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	http://www.prisar.eu
Total cost	2˙430˙000 €
EC max contribution	2˙430˙000 € (100%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2014
Funding Scheme	MSCA-RISE
Starting year	2015
Duration (year-month-day)	from 2015-02-01 to 2019-01-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	PERCUROS BV PERCUROS BV Organization address address: PLESMANLAAN 1 city: LEIDEN postcode: 2333 BZ website: www.percuros.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	coordinator	378˙000.00
2	ACADEMISCH ZIEKENHUIS LEIDEN ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	486˙000.00
3	UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS UNIVERSITAETSMEDIZIN GOETTINGEN - GEORG-AUGUST-UNIVERSITAET GOETTINGEN - STIFTUNG OEFFENTLICHEN RECHTS Organization address address: Robert-Koch-Strasse 40 city: GOETTINGEN postcode: 37075 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (GOETTINGEN)	participant	243˙000.00
4	RAYFOS LTD RAYFOS LTD Organization address address: WINTON HOUSE WINTON SQUARE city: BASINGSTOKE postcode: RG21 8EN website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BASINGSTOKE)	participant	216˙000.00
5	TECHNISCHE UNIVERSITAET MUENCHEN TECHNISCHE UNIVERSITAET MUENCHEN Organization address address: Arcisstrasse 21 city: MUENCHEN postcode: 80333 website: www.tu-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	189˙000.00
6	GAMMA TECHNOLOGIES LIMITED GAMMA TECHNOLOGIES LIMITED Organization address address: The Coliseum Riverside Way, Watchmoor Park city: Camberley postcode: GU15 3YL website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Camberley)	participant	162˙000.00
7	UNIVERSITEIT MAASTRICHT UNIVERSITEIT MAASTRICHT Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD website: http://www.maastrichtuniversity.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (MAASTRICHT)	participant	162˙000.00
8	MAUNA KEA TECHNOLOGIES MAUNA KEA TECHNOLOGIES Organization address address: 10 rue d'Enghien city: PARIS postcode: 75010 website: www.maunakeatech.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	108˙000.00
9	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	108˙000.00
10	TAGWORKS PHARMACEUTICALS BV TAGWORKS PHARMACEUTICALS BV Organization address address: Vondellaan 11 city: Eindhoven postcode: 5611 NX website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Eindhoven)	participant	108˙000.00
11	TECOBIOSCIENCES GMBH TECOBIOSCIENCES GMBH Organization address address: HABICHTSTRASSE 21 city: LANDSHUT postcode: 84036 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (LANDSHUT)	participant	108˙000.00
12	ANTIBODIES FOR RESEARCH APPLICATIONS BV ANTIBODIES FOR RESEARCH APPLICATIONS BV Organization address address: Leenmanslag 57 city: Gouda postcode: 2805 HT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Gouda)	participant	54˙000.00
13	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	participant	54˙000.00
14	ITHERA MEDICAL GMBH ITHERA MEDICAL GMBH Organization address address: ZIELSTATTSTRASSE 13 city: MUNCHEN postcode: 81379 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUNCHEN)	participant	54˙000.00

Map

Project objective

The main objective and basic concept of our proposal is to improve intra-operative and post-operative targeted surgical probes and new detection systems for surgical intervention of cancer. The work revolves around the mobility of clinicians, scientists and technologists between twelve consortium partners and across four different countries. The goal is the implementation of inter-disciplinary, inter-sector, cross-training of personnel. As a consequence, this will serve to accelerate the development of improved imaging technologies and hybrid fluorescence/radionuclide probes for the surgical intervention of cancer. The hypothesis is that if we can develop a hybrid probe for both targeted image-guided surgery and post-operative molecular radiotherapy, we would be implementing a revolutionary imaging and therapeutic approach for oncology surgeons to help their patients by improving better overall survival and quality of life for the patient. There are four key objectives within this project: 1) synthesis of a near infra-red fluorescence (NIRF)-dye conjugated to a peptide that is targeted towards a tumour associated antigen, 2) deliver a novel clinical optoacoustic handheld camera to detect the fluorescence probe in deep tissue, 3) validate the probe/target combination across the subcellular, cellular, endoscopic and macroscopic levels with state-of-art technologies, and 4) develop the probe further by targeting a radionuclide entity to the fluorescent construct for postoperative radiotherapy. Surgeons would have a more definitive reference for resection, if the tumour margin can be clearly defined. If this can be achieved, the impact would be (a) reduced recurrence rates in patients by lowering the risk of residual tumour tissue remaining after surgery and as a consequence improve survival, (b) minimised removal of healthy tissues, c) reduced patient morbidity and hospital stay and d) significant health cost benefits.

Publications

List of publications.
year	authors and title	journal	last update
2019	Timo Schomann, Laura Mezzanotte, John C.M.J. de Groot, Clemens W.G.M. LÃ¶wik, Johan H.M. Frijns, Margriet A. Huisman Imaging bioluminescent exogenous stem cells in the intact guinea pig cochlea published pages: , ISSN: 1932-8486, DOI: 10.1002/ar.24068	The Anatomical Record	2019-10-08
2018	Chih Kit Chung, C.G. Da Silva, Dana Kralisch, Alan Chan, Ferry Ossendorp, Luis J. Cruz Combinatory therapy adopting nanoparticle-based cancer vaccination with immune checkpoint blockade for treatment of post-surgical tumor recurrences published pages: 56-66, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2018.07.011	Journal of Controlled Release 285	2019-10-08
2018	Timo Schomann, Dyan Ramekers, John C. M. J. de Groot, Carola H. van der Ploeg, Ferry G. J. Hendriksen, Stefan BÃ¶hringer, Sjaak F. L. Klis, Johan H. M. Frijns, Margriet A. Huisman Ouabain Does Not Induce Selective Spiral Ganglion Cell Degeneration in Guinea Pigs published pages: 1-15, ISSN: 2314-6133, DOI: 10.1155/2018/1568414	BioMed Research International 2018	2019-10-03
2016	Marieke A. Stammes, Vicky T. Knol-Blankevoort, Luis J. Cruz, Hans R. I. J. Feitsma, Laura Mezzanotte, Robert A. Cordfunke, Riccardo Sinisi, Elena A. Dubikovskaya, Azusa Maeda, Ralph S. DaCosta, Katja Bierau, Alan Chan, Eric L. Kaijzel, Thomas J. A. Snoeks, Ermond R. van Beek, Clemens W. G. M. LÃ¶wik Pre-clinical Evaluation of a Cyanine-Based SPECT Probe for Multimodal Tumor Necrosis Imaging published pages: , ISSN: 1536-1632, DOI: 10.1007/s11307-016-0972-7	Molecular Imaging and Biology	2019-10-03
2016	Susanna W. L. de Geus, Leonora S. F. Boogerd, Rutger-Jan Swijnenburg, J. Sven D. Mieog, Willemieke S. F. J. Tummers, Hendrica A. J. M. Prevoo, Cornelis F. M. Sier, Hans Morreau, Bert A. Bonsing, Cornelis J. H. van de Velde, Alexander L. Vahrmeijer, Peter J. K. Kuppen Selecting Tumor-Specific Molecular Targets in Pancreatic Adenocarcinoma: Paving the Way for Image-Guided Pancreatic Surgery published pages: 1-13, ISSN: 1536-1632, DOI: 10.1007/s11307-016-0959-4	Molecular Imaging and Biology	2019-10-03
2017	Eric L. Kaijzel, Ermond R. van Beek, Marieke A. Stammes, Ivo Que, Alan B. Chan, Clemens W.G.M. LÃ¶wik, Luis J. Cruz. Traumatic Brain Injury: Preclinical Imaging Diagnostic(s) and Therapeutic Approaches published pages: , ISSN: 1381-6128, DOI: 10.2174/1381612823666170116141116	Current Pharmaceutical Design 23	2019-10-03
2016	M Saccomano, M Stammes, A Chan, F Alves, J Napp Intraoperative Bildgebung von Pankreastumoren: PrÃ¤klinische Validierung von Cetuximab konjugiert an Fluoreszenzfarbstoffe im Nahen Infrarotbereich im orthotopen Pankreastumor-Mausmodell published pages: , ISSN: 0044-2771, DOI: 10.1055/s-0036-1587241	Zeitschrift fÃ¼r Gastroenterologie 54/08	2019-10-03
2016	LÃ¶wik, Clemens; Fish, A.; Lelieveldt, Boudewijn; Dijkstra, Jouke; Cordfunke, R. A.; Tummers, Q.R.J.G.; Driel, Pieter; Vahrmeijer, A. L.; Snoeks, thomas; Velde, Cornelis; Boonstra, M.; Kuppen, P J K; Keereweer, Stijn; Van de Giessen, Martijn; Prevoo, H.A.J.M.; Sier, Cornelis; van Eendenburg, J. D. H. EpCAM as multi-tumour target for near-infrared fluorescence guided surgery published pages: , ISSN: 1471-2407, DOI: 10.1186/s12885-016-2932-7	B M C Cancer, 16(1) 1	2019-10-03
2016	Mara Saccomano, Christian Dullin, Frauke Alves, Joanna Napp Preclinical evaluation of near-infrared (NIR) fluorescently labeled Cetuximab as a potential tool for fluorescence-guided surgery published pages: , ISSN: 0020-7136, DOI: 10.1002/ijc.30277	International Journal of Cancer	2019-10-03
2015	Sier CF, Bhairosing S, Prevoo HA, van Vlierberghe RL, Hawinkels LJ, Mesker WE, Van de Velde CJ, Kuppen PJ, Vahrmeijer AL Stromal cells as target for image-guided surgery of breast cancer. published pages: 130-131, ISSN: , DOI: 10.1007/s12307-015-0175-9	Cancer Microenvironment 8 Suppl. 1	2019-10-03
2017	Inge A. Mulder, Artem Khmelinskii, Oleh Dzyubachyk, Sebastiaan de Jong, Nathalie Rieff, Marieke J. Wermer, Mathias Hoehn, Boudewijn Lelieveldt and Arn M. van den Maagdenberg Automated ischemic lesion segmentation in MRI mouse brain data after transient middle cerebral artery occlusion published pages: , ISSN: 1662-453X, DOI: 10.3389/fninf.2017.00003	Frontiers in Neuroinformatics 11:3	2019-10-03
2016	Walid M. Abdelmoula, Benjamin Balluff, Sonja Englert, Jouke Dijkstra, Marcel J. T. Reinders, Axel Walch, Liam A. McDonnell, Boudewijn P. F. Lelieveldt Data-driven identification of prognostic tumor subpopulations using spatially mapped t-SNE of mass spectrometry imaging data published pages: 12244-12249, ISSN: 0027-8424, DOI: 10.1073/pnas.1510227113	Proceedings of the National Academy of Sciences 113/43	2019-10-03
2017	M.C. Boonstra, P.B.A.A. Van Driel, S. Keereweer, H.A.J.M. Prevoo, M.A. Stammes, V.M. Baart, C.W.G.M. LÃ¶wik, A.P. Mazar, C.J.H. van de Velde, A.L. Vahrmeijer, C.F.M. Sier Preclinical uPAR-targeted multimodal imaging of locoregional oral cancer published pages: 1-8, ISSN: 1368-8375, DOI: 10.1016/j.oraloncology.2016.12.026	Oral Oncology	2019-10-03
2016	Inge T. A. Peters, Carina G. J. M. Hilders, Cornelis F. M. Sier, Alexander L. Vahrmeijer, Vincent T. H. B. M. Smit, J. Baptist Trimbos, Peter J. K. Kuppen Identification of cell-surface markers for detecting breast cancer cells in ovarian tissue published pages: , ISSN: 0932-0067, DOI: 10.1007/s00404-016-4036-7	Archives of Gynecology and Obstetrics	2019-10-03
2016	Ivan Olefir, Elena Mercep, Neal C. Burton, Saak V. Ovsepian, Vasilis Ntziachristos Hybrid multispectral optoacoustic and ultrasound tomography for morphological and physiological brain imaging published pages: 86005, ISSN: 1083-3668, DOI: 10.1117/1.JBO.21.8.086005	Journal of Biomedical Optics 21/8	2019-10-03
2017	Marieke A. Stammes, Hendrica A. J. M. Prevoo, Meyke C. Ter Horst, StÃ©phanie A. Groot, Cornelis J. H. Van de Velde, Alan B. Chan, Lioe-Fee de Geus-Oei, Peter J. K. Kuppen, Alexander L. Vahrmeijer, Elena B. Pasquale and Cornelis F. M. Sier Evaluation of EphA2 and EphB4 as Targets for Image-Guided Colorectal Cancer Surgery published pages: 307, ISSN: 1422-0067, DOI: 10.3390/ijms18020307	Int. J. Mol. Sci 2017, 18(2):307	2019-10-03
2016	Marieke A. Stammes, Azusa Maeda, Jiachuan Bu, Deborah A. Scollard, Iris Kulbatski, Philip J. Medeiros, Riccardo Sinisi, Elena A. Dubikovskaya, Thomas J. A. Snoeks, Ermond R. van Beek, Alan B. Chan, Clemens W. G. M. LÃ¶wik, Ralph S. DaCosta The Necrosis-Avid Small Molecule HQ4-DTPA as a Multimodal Imaging Agent for Monitoring Radiation Therapy-Induced Tumor Cell Death published pages: , ISSN: 2234-943X, DOI: 10.3389/fonc.2016.00221	Frontiers in Oncology 6	2019-10-03
2017	Joanna Napp, Marieke A. Stammes, Jing Claussen, Hendrica A.J.M. Prevoo, Cornelis F. M. Sier, Freek J. M. Hoeben, Marc S. Robillard, Alexander L. Vahrmeijer, Tim Devling, Alan B. Chan, Lioe-Fee de Geus-Oei, Frauke Alves Fluorescence- and multispectral optoacoustic imaging for an optimised detection of deeply located tumours in an orthotopic mouse model of pancreatic carcinoma published pages: , ISSN: 0020-7136, DOI: 10.1002/ijc.31236	International Journal of Cancer	2019-10-03
2016	Vahrmeijer, Alexander L.; Prevoo, Hendrica A.J.M; Hawinkels, Lukas J.A.C.; Kuppen, Peter J. K.; Boonstra, Martin C.; Cornelis F.M. Sier; de Geus, Susanna W L; van de Velde, Cornelis J.H. Selecting Targets for Tumor Imaging: An Overview of Cancer-Associated Membrane Proteins published pages: , ISSN: 1179-299X, DOI: 10.4137/BIC.S38542	Biomarkers in Cancer, Vol 2016, Iss 8, Pp 119-133 (2016) 1	2019-10-03
2016	Maria Anastasopoulou, Maximilian Koch, Dimitris Gorpas, Angelos Karlas, Uwe Klemm, Pilar Beatriz Garcia-Allende, Vasilis Ntziachristos Comprehensive phantom for interventional fluorescence molecular imaging published pages: 91309, ISSN: 1083-3668, DOI: 10.1117/1.JBO.21.9.091309	Journal of Biomedical Optics 21/9	2019-10-03

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