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Matrix glycans as multifunctional pathogenesis factors and therapeutic targets in cancer

Total Cost €


EC-Contrib. €






 GLYCANC project word cloud

Explore the words cloud of the GLYCANC project. It provides you a very rough idea of what is the project "GLYCANC" about.

immune    acts    disease    mortality    combined    weinberg    stroma    metastasis    cells    tumor    deeper    chemokines    proteoglycans    cell    aberrant    besides    structurally    underlying    adhesion    epigenetic    pharmacological    surfaces    structures    modulation    rational    integrins    expression    pgs    transfer    2011    molecular    hampered    simultaneously    therapeutic    gags    expertise    basis    integrate    emerged    pg    dysregulated    interactions    hanahan    structural    glycan    performing    progression    survival    entities    stem    function    biomarkers    hallmarks    matrix    elucidating    antitumoral    analysing    glycosaminoglycans    extracellular    anticancer    applicable    levels    modulate    multitargeted    population    microenvironment    training    diverse    complexity    glycans    attractive    micrornas    extensive    aging    malignant    signals    emerges    glycanc    regulation    methodology    gag    shown    mechanisms    hypothesize    multiple    niches    angiogenesis    dependent    players    cancer    itself    carbohydrates   

Project "GLYCANC" data sheet

The following table provides information about the project.


Organization address
postcode: 48149
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Project website
 Total cost 567˙000 €
 EC max contribution 567˙000 € (100%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2014
 Funding Scheme MSCA-RISE
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2019-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
3    PANEPISTIMIO PATRON EL (RIO PATRAS) participant 103˙500.00
4    SEMMELWEIS EGYETEM HU (BUDAPEST) participant 67˙500.00
7    UPPSALA UNIVERSITET SE (UPPSALA) participant 45˙000.00
8    FIDIA FARMACEUTICI SPA IT (Abano Terme) participant 27˙000.00
9    SEREND-IP GMBH DE (MUENSTER) participant 4˙500.00
10    CAIRO UNIVERSITY EG (GIZA) partner 0.00
12    EWHA WOMANS UNIVERSITY KR (Seoul) partner 0.00


 Project objective

Cancer is a leading cause of mortality within the aging European population. Therapeutic targeting is hampered by the complexity of the disease, which includes not only molecular changes within the tumor cell itself, but also within its microenvironment. Tumor angiogenesis, tumor-stroma interactions, interactions with immune cells, with the extracellular matrix and cancer stem cell niches allow for malignant cell survival and promote metastasis, the leading cause for cancer-associated mortality. Proteoglycans (PGs) and glycosaminoglycans (GAGs) – structurally diverse carbohydrates of the extracellular matrix and cell surfaces - have emerged as novel biomarkers and molecular players both within tumor cells and their microenvironment, as they integrate signals from growth factors, chemokines and integrins, and cell-cell as well as matrix adhesion. Importantly, their expression is dysregulated in numerous tumor entities, and has been shown to modulate each of the hallmarks of cancer as defined by Hanahan and Weinberg (Cell 2011). We hypothesize that dysregulated function of PGs and GAGs simultaneously affects all molecular steps towards cancer metastasis as a general principle applicable to multiple tumor entities. Pharmacological modulation of their function thus emerges as an attractive multitargeted antitumoral approach which simultaneously acts at multiple levels of disease progression. Besides providing extensive knowledge transfer and training for researchers, the combined expertise of the GLYCANC consortium aims at performing a detailed structural analysis of PG and GAG glycans in disease using state-of-the art methodology, analysing their regulation via epigenetic mechanisms and microRNAs, and elucidating molecular mechanisms underlying aberrant PG and GAG function. GLYCANC will lead to a deeper understanding of glycan structures and glycan-dependent mechanisms promoting cancer progression, providing the basis for rational multitargeted anticancer approaches.


List of deliverables.
Chemotherapeutic resistance Documents, reports 2020-01-28 11:49:34
In vitro analysis of microRNA-dependent Syndecan-1 regulation in IBC Documents, reports 2020-01-28 11:49:34
Mechanistic in vitro investigation of Syndecan-dependenttranscriptional activation Documents, reports 2020-01-28 11:49:34
Inhibitory effect of 4- MU in vivo Documents, reports 2020-01-28 11:49:34
Analysis of signaling pathways Documents, reports 2020-01-28 11:49:34
Methods for preprocessing and processing of spectral data Documents, reports 2020-01-28 11:49:34
In vitro functional assays in a novel 3D culture system Documents, reports 2020-01-28 11:49:33
Functional in vitro studies Documents, reports 2020-01-28 11:49:33
In vivo study on the premetastatic niche Documents, reports 2020-01-28 11:49:33
Immune cells in the microenvironment Documents, reports 2020-01-28 11:49:33
Angiogenesis regulators Documents, reports 2020-01-28 11:49:33
Nanostic analysis Documents, reports 2020-01-28 11:49:33
Role of Syndecan-1 oligomerization in FAK activation Documents, reports 2020-01-28 11:49:33
Proof of concept for in vivo Raman probes for diagnosis of melanoma in patients and application to tumor-associated macrophages Documents, reports 2020-01-28 11:49:34
Analysis of angiogenic factors in immunomodulatory cells Documents, reports 2020-01-28 11:49:33
3D culture Documents, reports 2020-01-28 11:49:33
Functional impact of miRNA-dependent PG and HAS regulation Documents, reports 2020-01-28 11:49:33
Microvascular density Documents, reports 2020-01-28 11:49:33
Role of PGs in TGFbeta induced EMT Documents, reports 2020-01-28 11:49:33
Therapeutic potential of Ascidian GAGs Documents, reports 2020-01-28 11:49:33
Characterization of HA molecular weight from tumor and control tissue of at least three in vivo mouse tumor models Documents, reports 2020-01-28 11:49:33
ChIP experiments Documents, reports 2020-01-28 11:49:33
Impact of conventional therapeutics on the premetastatic niche Documents, reports 2020-01-28 11:49:31
microRNA-regulation of Syndecan-1 in clinical IBC specimens Documents, reports 2020-01-28 11:49:29
In vitro study of the premetastatic niche Documents, reports 2020-01-28 11:49:31
Changes in EMT marker expression Documents, reports 2020-01-28 11:49:31
Impact of PGs and GAGs on premature senescence of cancer cells Documents, reports 2020-01-28 11:49:30
Characterization of HS disaccharide structure from 8 breast cancer cell lines with altered Syndecan-1, 3-O-HS sulfation and 2-O-HS sulfation Documents, reports 2020-01-28 11:49:29
Epigenetic HAS2 promoter regulation Documents, reports 2020-01-28 11:49:30
Workshop on epigenetic regulation Websites, patent fillings, videos etc. 2020-01-28 11:49:30
Workshop on PGs and GAGs in metastasis Websites, patent fillings, videos etc. 2020-01-28 11:49:31
Diagnostic value of Syndecan-1 in IBC Documents, reports 2020-01-28 11:49:31
In vivo model of hepatocarcinogenesis Documents, reports 2020-01-28 11:49:29
microRNA regulation of Glypican-1, Syndecan-2 and HAS1-3 in breast and colon cancer Documents, reports 2020-01-28 11:49:29
Flow cytometric analysis of SP and ALDH phenotype Documents, reports 2020-01-28 11:49:30
Standardized Protocol for Tissue Microarray Analysis by FTIR and RAMAN spectroscopy Documents, reports 2020-01-28 11:49:32
Evaluation of HA related enzyme expression Documents, reports 2020-01-28 11:49:31
Standardized protocol for FTIR and RAMAN spectroscopic analysis of GAGs in cells and conditioned media. Documents, reports 2020-01-28 11:49:30
Impact of PG/HA on DNA damage response Documents, reports 2020-01-28 11:49:30
qPCR analysis of angiogenic factors in tumors Documents, reports 2020-01-28 11:49:31
Flow cytometric and qPCR analysis of stem cell markers Documents, reports 2020-01-28 11:49:32
Correlation of GAG structure with clinicopathological parameters Documents, reports 2020-01-28 11:49:31
Proof of concept to determine GAGs composition in cancer stromal tissue Documents, reports 2020-01-28 11:49:32
Spectroscopic delineation of the expression of GAGs in mice lung metastatic nodules Documents, reports 2020-01-28 11:49:32
Establichment of GLYCANC Website Websites, patent fillings, videos etc. 2020-01-28 11:49:31
Spectroscopic delineation of the expression of GAGs in murine melanoma, and PG-manuipulated cancer cell lines Documents, reports 2020-01-28 11:49:31
Changes in invasive behaviour Documents, reports 2020-01-28 11:49:31
Analysis of glioblastoma cell line GAG structure Documents, reports 2020-01-28 11:49:31

Take a look to the deliverables list in detail:  detailed list of GLYCANC deliverables.


year authors and title journal last update
List of publications.
2019 Alberto Passi, Davide Vigetti, Simone Buraschi, Renato V. Iozzo
Dissecting the role of hyaluronan synthases in the tumor microenvironment
published pages: 2937-2949, ISSN: 1742-464X, DOI: 10.1111/febs.14847
The FEBS Journal 286/15 2020-01-28
2019 Anastasia-Gerasimoula Tavianatou, Zoi Piperigkou, Carlo Barbera, Riccardo Beninatto, Valentina Masola, Ilaria Caon, Maurizio Onisto, Marco Franchi, Devis Galesso, Nikos K. Karamanos
Molecular size-dependent specificity of hyaluronan on functional properties, morphology and matrix composition of mammary cancer cells
published pages: 100008, ISSN: 2590-0285, DOI: 10.1016/j.mbplus.2019.100008
Matrix Biology Plus 2020-01-28
2019 Moshira Ezzat Saleh, Ramy Gadalla, Hebatallah Hassan, Ahmed Afifi, Martin Götte, Mohamed El-Shinawi, Mona Mostafa Mohamed, Sherif Abdelaziz Ibrahim
The immunomodulatory role of tumor Syndecan-1 (CD138) on ex vivo tumor microenvironmental CD4+ T cell polarization in inflammatory and non-inflammatory breast cancer patients
published pages: e0217550, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0217550
PLOS ONE 14/5 2020-01-28
2019 Fiorella M. Spinelli, Daiana L. Vitale, Antonella Icardi, Ilaria Caon, Alejandra Brandone, Paula Giannoni, Virginia Saturno, Alberto Passi, Mariana García, Ina Sevic, Laura Alaniz
Hyaluronan preconditioning of monocytes/macrophages affects their angiogenic behavior and regulation of TSG ‐6 expression in a tumor type‐specific manner
published pages: , ISSN: 1742-464X, DOI: 10.1111/febs.14871
The FEBS Journal 2020-01-28
2018 Martin Götte, Ilona Kovalszky
Extracellular matrix functions in lung cancer
published pages: , ISSN: 0945-053X, DOI: 10.1016/j.matbio.2018.02.018
Matrix Biology 2020-01-28
2018 Theodoros T. Karalis, Paraskevi Heldin, Demitrios H. Vynios, Thomas Neill, Simone Buraschi, Renato V. Iozzo, Nikos K. Karamanos, Spyros S. Skandalis
Tumor-suppressive functions of 4-MU on breast cancer cells of different ER status: Regulation of hyaluronan/HAS2/CD44 and specific matrix effectors
published pages: , ISSN: 0945-053X, DOI: 10.1016/j.matbio.2018.04.007
Matrix Biology 2020-01-28
2018 Daiana L. Vitale, Fiorella M. Spinelli, Daiana Del Dago, Antonella Icardi, Gianina Demarchi, Ilaria Caon, Mariana García, Marcela F. Bolontrade, Alberto Passi, Carolina Cristina, Laura Alaniz
Co-treatment of tumor cells with hyaluronan plus doxorubicin affects endothelial cell behavior independently of VEGF expression
published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.26379
Oncotarget 9/93 2020-01-28
2019 Eszter Regős, Katalin Karászi, Andrea Reszegi, András Kiss, Zsuzsa Schaff, Kornélia Baghy, Ilona Kovalszky
Syndecan-1 in Liver Diseases
published pages: , ISSN: 1219-4956, DOI: 10.1007/s12253-019-00617-0
Pathology & Oncology Research 2020-01-28
2017 S. Brézillon, V. Untereiner, H. T. Mohamed, J. Hodin, A. Chatron-Colliet, F.-X. Maquart, G. D. Sockalingum
Probing glycosaminoglycan spectral signatures in live cells and their conditioned media by Raman microspectroscopy
published pages: 1333-1341, ISSN: 0003-2654, DOI: 10.1039/C6AN01951J
The Analyst 142/8 2020-01-28
2017 Sherif Abdelaziz Ibrahim, Ramy Gadalla, Eslam A. El-Ghonaimy, Omnia Samir, Hossam Taha Mohamed, Hebatallah Hassan, Burkhard Greve, Mohamed El-Shinawi, Mona Mostafa Mohamed, Martin Götte
Syndecan-1 is a novel molecular marker for triple negative inflammatory breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3, Notch and EGFR signaling pathways
published pages: 57, ISSN: 1476-4598, DOI: 10.1186/s12943-017-0621-z
Molecular Cancer 16/1 2020-01-28
2015 Alexander Schwickert, Esther Weghake, Kathrin Brüggemann, Annika Engbers, Benjamin F. Brinkmann, Björn Kemper, Jochen Seggewiß, Christian Stock, Klaus Ebnet, Ludwig Kiesel, Christoph Riethmüller, Martin Götte
microRNA miR-142-3p Inhibits Breast Cancer Cell Invasiveness by Synchronous Targeting of WASL, Integrin Alpha V, and Additional Cytoskeletal Elements
published pages: e0143993, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0143993
PLOS ONE 10/12 2020-01-28
2016 Hossam Taha Mohamed, Valérie Untereiner, Ganesh D. Sockalingum, Stéphane Brézillon
Implementation of infrared and Raman modalities for glycosaminoglycan characterization in complex systems
published pages: , ISSN: 0282-0080, DOI: 10.1007/s10719-016-9743-6
Glycoconjugate Journal 2020-01-28
2018 Eszter Regős, Hadeer Hesham Abdelfattah, Andrea Reszegi, László Szilák, Klára Werling, Gábor Szabó, András Kiss, Zsuzsa Schaff, Ilona Kovalszky, Kornélia Baghy
Syndecan-1 inhibits early stages of liver fibrogenesis by interfering with TGFβ1 action and upregulating MMP14
published pages: , ISSN: 0945-053X, DOI: 10.1016/j.matbio.2018.02.008
Matrix Biology 2020-01-28
2017 Viviana Filpa, Michela Bistoletti, Ilaria Caon, Elisabetta Moro, Annalisa Grimaldi, Paola Moretto, Andreina Baj, Maria Cecilia Giron, Evgenia Karousou, Manuela Viola, Francesca Crema, Gianmario Frigo, Alberto Passi, Cristina Giaroni, Davide Vigetti
Changes in hyaluronan deposition in the rat myenteric plexus after experimentally-induced colitis
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-18020-7
Scientific Reports 7/1 2020-01-28
2017 Konstantina Karamanou, Diana Carolina Restrepo Espinosa, Anneliese Fortuna-Costa, Mauro Sérgio Gonçalves Pavão
Biological function of unique sulfated glycosaminoglycans in primitive chordates
published pages: 277-283, ISSN: 0282-0080, DOI: 10.1007/s10719-016-9728-5
Glycoconjugate Journal 34/3 2020-01-28
2017 Zoi Piperigkou, Martin Götte, Achilleas D. Theocharis, Nikos K. Karamanos
Insights into the key roles of epigenetics in matrix macromolecules-associated wound healing
published pages: , ISSN: 0169-409X, DOI: 10.1016/j.addr.2017.10.008
Advanced Drug Delivery Reviews 2020-01-28
2016 Zoi Piperigkou, Benedikt Mohr, Nikos Karamanos, Martin Götte
Shed proteoglycans in tumor stroma
published pages: , ISSN: 0302-766X, DOI: 10.1007/s00441-016-2452-4
Cell and Tissue Research 2020-01-28
2017 Argyris Spyrou, Soumi Kundu, Lulu Haseeb, Di Yu, Tommie Olofsson, Keith Dredge, Edward Hammond, Uri Barash, Israel Vlodavsky, Karin Forsberg-Nilsson
Inhibition of Heparanase in Pediatric Brain Tumor Cells Attenuates their Proliferation, Invasive Capacity, and In Vivo Tumor Growth
published pages: 1705-1716, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-16-0900
Molecular Cancer Therapeutics 16/8 2020-01-28
2017 Nikolaos A. Afratis, Panagiotis Bouris, Spyros S. Skandalis, Hinke A. Multhaupt, John R. Couchman, Achilleas D. Theocharis, Nikos K. Karamanos
IGF-IR cooperates with ERα to inhibit breast cancer cell aggressiveness by regulating the expression and localisation of ECM molecules
published pages: 40138, ISSN: 2045-2322, DOI: 10.1038/srep40138
Scientific Reports 7 2020-01-28
2017 Eleni Mavrogonatou, Harris Pratsinis, Adamantia Papadopoulou, Nikos K. Karamanos, Dimitris Kletsas
Extracellular matrix alterations in senescent cells and their significance in tissue homeostasis
published pages: , ISSN: 0945-053X, DOI: 10.1016/j.matbio.2017.10.004
Matrix Biology 2020-01-28
2017 Evgenia Karousou, Suniti Misra, Shibnath Ghatak, Katalin Dobra, Martin Götte, Davide Vigetti, Alberto Passi, Nikos K. Karamanos, Spyros S. Skandalis
Roles and targeting of the HAS/hyaluronan/CD44 molecular system in cancer
published pages: 3-22, ISSN: 0945-053X, DOI: 10.1016/j.matbio.2016.10.001
Matrix Biology 59 2020-01-28
2017 Manuela Viola, Kathrin Brüggemann, Evgenia Karousou, Ilaria Caon, Elena Caravà, Davide Vigetti, Burkhard Greve, Christian Stock, Giancarlo De Luca, Alberto Passi, Martin Götte
MDA-MB-231 breast cancer cell viability, motility and matrix adhesion are regulated by a complex interplay of heparan sulfate, chondroitin−/dermatan sulfate and hyaluronan biosynthesis
published pages: 411-420, ISSN: 0282-0080, DOI: 10.1007/s10719-016-9735-6
Glycoconjugate Journal 34/3 2020-01-28
2017 Zoi Piperigkou, Marco Franchi, Martin Götte, Nikos K. Karamanos
Estrogen receptor beta as epigenetic mediator of miR-10b and miR-145 in mammary cancer
published pages: , ISSN: 0945-053X, DOI: 10.1016/j.matbio.2017.08.002
Matrix Biology 2020-01-28
2019 Moshira Ezzat Saleh, Ramy Gadalla, Hebatallah Hassan, Ahmed Afifi, Martin Götte, Mohamed El-Shinawi, Mona Mostafa Mohamed, Sherif Abdelaziz Ibrahim
The immunomodulatory role of tumor Syndecan-1 (CD138) on ex vivo tumor microenvironmental CD4+ T cell polarization in inflammatory and non-inflammatory breast cancer patients
published pages: e0217550, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0217550
PLOS ONE 14/5 2020-01-28

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