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VIVOIMAG

Multimodal imaging of the in vivo fate of bone transplants

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

VIVOIMAG project word cloud

Explore the words cloud of the VIVOIMAG project. It provides you a very rough idea of what is the project "VIVOIMAG" about.

implant characterization progress implants academic tissue first transplanted permit vivo sensitive substitute mri cell techniques modified prolonged endowed community animal enzymatic follow metaloproteases magnetically obtain industrial medical grafts seeding vivoimag reporting integration extracellular formulation accomplishment scintigraphic resonance brings successful integrating cells time society collaborative sacrificing monitored implanting bone material scientific ones scaffolds sharing regeneration contrast technique differentiation situ specialists nanoparticles noninvasively outcomes social training animals functionalized bioreactors join detect biopsies engineering magnetic vitro exchange forces matrix maximize fate series previously huge living invasive agent multidisciplinary models achievement evaluation imaging

Project "VIVOIMAG" data sheet

The following table provides information about the project.

Coordinator	"NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS""" Organization address address: END OF PATRIARCHOU GRIGORIOU E AND 27 NEAPOLEOS STREET city: AGIA PARASKEVI postcode: 15341 website: www.demokritos.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Greece [EL]
Project website	http://www.vivoimag.eu
Total cost	472˙500 €
EC max contribution	472˙500 € (100%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2014
Funding Scheme	MSCA-RISE
Starting year	2015
Duration (year-month-day)	from 2015-06-01 to 2019-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	"NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS""" "NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS""" Organization address address: END OF PATRIARCHOU GRIGORIOU E AND 27 NEAPOLEOS STREET city: AGIA PARASKEVI postcode: 15341 website: www.demokritos.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (AGIA PARASKEVI)	coordinator	72˙000.00
2	BIOEMISSION TECHNOLOGY SOLUTIONS IKE BIOEMISSION TECHNOLOGY SOLUTIONS IKE Organization address address: ALEXANDRAS AVENUE 116 city: ATHINA postcode: 114 72 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (ATHINA)	participant	135˙000.00
3	BIOIMAG SOLUCIONES DE CONTRASTE SL BIOIMAG SOLUCIONES DE CONTRASTE SL Organization address address: CARRETERA N 521 KM 41,800 city: CACERES postcode: 10071 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (CACERES)	participant	103˙500.00
4	UNIVERSITY OF LEEDS UNIVERSITY OF LEEDS Organization address address: WOODHOUSE LANE city: LEEDS postcode: LS2 9JT website: www.leeds.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LEEDS)	participant	67˙500.00
5	CONSIGLIO NAZIONALE DELLE RICERCHE CONSIGLIO NAZIONALE DELLE RICERCHE Organization address address: PIAZZALE ALDO MORO 7 city: ROMA postcode: 185 website: www.cnr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	58˙500.00
6	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	18˙000.00
7	UNIVERSITE DE MONS UNIVERSITE DE MONS Organization address address: PLACE DU PARC 20 city: MONS postcode: 7000 website: www.umons.ac.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (MONS)	participant	18˙000.00
8	BONUS THERAPEUTIC LTD BONUS THERAPEUTIC LTD Organization address address: 8 A BLDG MATAM ADVANCED TECHNOLOGY PARK city: HAIFA postcode: 3508408 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (HAIFA)	participant	0.00

Map

Project objective

The main objective of VIVOIMAG is to develop bone implants including a new contrast agent sensitive to enzymatic activity of metaloproteases, which will permit for the first time to follow the integration and cell differentiation activity in bone tissue bioreactors in vitro and in grafts in vivo using existing non invasive magnetic resonance imaging techniques. The proposal aims at integrating a magnetically functionalized extracellular matrix material into the bone scaffolds, seeding them with cells, implanting them in animal models and following the fate of the implants in vivo using MRI. The aim is to obtain similar results with the magnetically modified scaffolds as the ones obtained currently but having now endowed the grafts with enzymatic reporting activity that can be monitored noninvasively in the living animal. There are currently no methods to detect in situ and in vivo this enzymatic activity without previously sacrificing the transplanted animals, therefore the successful accomplishment of this project would have huge and prolonged impact in the medical field of tissue regeneration. The VIVOIMAG project brings together a multidisciplinary consortium of specialists in different areas of bone implant research, nanoparticles formulation and characterization, magnetic resonance and scintigraphic imaging, who will join forces in order to propose and assess a novel technique for the evaluation of the progress of bone implants in vivo, which can substitute existing invasive techniques based on biopsies. A well planned exchange program among academic and industrial partners will facilitate knowledge sharing, maximize collaborative work and finally achievement of project objectives. The consortium, being aware of the scientific and social importance of bone tissue engineering, has planned a series of dissemination and training activities, aiming at making project knowledge and outcomes available to the scientific community and society.

Deliverables

List of deliverables.
Report on the organized events and related material	Documents, reports	2019-11-29 10:51:13
Report on performed outreach activities and material	Documents, reports	2019-11-29 10:51:13
Project logo, brochure and first version of website	Websites, patent fillings, videos etc.	2019-11-29 10:51:12

Take a look to the deliverables list in detail: detailed list of VIVOIMAG deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2017	Rouchota M., Georgiou M., Fysikopoulos E., Fragogeorgi E., Mikropoulos K., Papadimitroulas P., Kagadis G., Loudos G. A prototype PET/SPECT/X-rays scanner dedicated for whole body small animal studies. published pages: 146-153, ISSN: 1790-5427, DOI: 10.1967/s002449910556	Hellenic Journal of Nuclear Medicine May-Aug 2017, Volume 20, Issue	2019-11-29
2017	Eirini Fragogeorgi, Julian Daich, Eleftherios Fysikopoulos, Simon Lacroix, Gilles Doumont, Maria Georgiou, Dimitri Stanicki, Marcos Pita, Sophie Laurent, Penelope Bouziotis, Marisela Velez, George Loudos Collagen scaffolds labelled with MRI and SPECT contrast agents for non-invasive imaging in bone tissue engineering published pages: \"#PW 16 / 165 , ISSN: , DOI:	European Molecular Imaging Meeting - EMIM 2017 5-7 April 2017, Cologne, german	2019-11-29

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The information about "VIVOIMAG" are provided by the European Opendata Portal: CORDIS opendata.