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VIVOIMAG

Multimodal imaging of the in vivo fate of bone transplants

Total Cost €

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EC-Contrib. €

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Partnership

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 VIVOIMAG project word cloud

Explore the words cloud of the VIVOIMAG project. It provides you a very rough idea of what is the project "VIVOIMAG" about.

multidisciplinary    functionalized    academic    mri    successful    imaging    scaffolds    forces    metaloproteases    animal    ones    industrial    implant    follow    endowed    integrating    prolonged    modified    invasive    noninvasively    monitored    models    situ    nanoparticles    achievement    cell    cells    differentiation    huge    progress    material    seeding    evaluation    agent    specialists    community    engineering    training    magnetic    characterization    society    substitute    permit    technique    matrix    reporting    sharing    transplanted    sensitive    tissue    scintigraphic    time    vivo    formulation    magnetically    accomplishment    enzymatic    first    join    obtain    exchange    previously    maximize    integration    detect    implants    animals    bioreactors    medical    series    vivoimag    regeneration    vitro    living    extracellular    grafts    resonance    social    biopsies    implanting    outcomes    contrast    sacrificing    brings    collaborative    bone    fate    scientific    techniques   

Project "VIVOIMAG" data sheet

The following table provides information about the project.

Coordinator
"NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS""" 

Organization address
address: END OF PATRIARCHOU GRIGORIOU E AND 27 NEAPOLEOS STREET
city: AGIA PARASKEVI
postcode: 15341
website: www.demokritos.gr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Greece [EL]
 Project website http://www.vivoimag.eu
 Total cost 472˙500 €
 EC max contribution 472˙500 € (100%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2014
 Funding Scheme MSCA-RISE
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2019-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    "NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS""" EL (AGIA PARASKEVI) coordinator 72˙000.00
2    BIOEMISSION TECHNOLOGY SOLUTIONS IKE EL (ATHINA) participant 135˙000.00
3    BIOIMAG SOLUCIONES DE CONTRASTE SL ES (CACERES) participant 103˙500.00
4    UNIVERSITY OF LEEDS UK (LEEDS) participant 67˙500.00
5    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 58˙500.00
6    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 18˙000.00
7    UNIVERSITE DE MONS BE (MONS) participant 18˙000.00
8    BONUS THERAPEUTIC LTD IL (HAIFA) participant 0.00

Map

 Project objective

The main objective of VIVOIMAG is to develop bone implants including a new contrast agent sensitive to enzymatic activity of metaloproteases, which will permit for the first time to follow the integration and cell differentiation activity in bone tissue bioreactors in vitro and in grafts in vivo using existing non invasive magnetic resonance imaging techniques. The proposal aims at integrating a magnetically functionalized extracellular matrix material into the bone scaffolds, seeding them with cells, implanting them in animal models and following the fate of the implants in vivo using MRI. The aim is to obtain similar results with the magnetically modified scaffolds as the ones obtained currently but having now endowed the grafts with enzymatic reporting activity that can be monitored noninvasively in the living animal. There are currently no methods to detect in situ and in vivo this enzymatic activity without previously sacrificing the transplanted animals, therefore the successful accomplishment of this project would have huge and prolonged impact in the medical field of tissue regeneration. The VIVOIMAG project brings together a multidisciplinary consortium of specialists in different areas of bone implant research, nanoparticles formulation and characterization, magnetic resonance and scintigraphic imaging, who will join forces in order to propose and assess a novel technique for the evaluation of the progress of bone implants in vivo, which can substitute existing invasive techniques based on biopsies. A well planned exchange program among academic and industrial partners will facilitate knowledge sharing, maximize collaborative work and finally achievement of project objectives. The consortium, being aware of the scientific and social importance of bone tissue engineering, has planned a series of dissemination and training activities, aiming at making project knowledge and outcomes available to the scientific community and society.

 Deliverables

List of deliverables.
Report on the organized events and related material Documents, reports 2019-11-29 10:51:13
Report on performed outreach activities and material Documents, reports 2019-11-29 10:51:13
Project logo, brochure and first version of website Websites, patent fillings, videos etc. 2019-11-29 10:51:12

Take a look to the deliverables list in detail:  detailed list of VIVOIMAG deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 Rouchota M., Georgiou M., Fysikopoulos E., Fragogeorgi E., Mikropoulos K., Papadimitroulas P., Kagadis G., Loudos G.
A prototype PET/SPECT/X-rays scanner dedicated for whole body small animal studies.
published pages: 146-153, ISSN: 1790-5427, DOI: 10.1967/s002449910556
Hellenic Journal of Nuclear Medicine May-Aug 2017, Volume 20, Issue 2019-11-29
2017 Eirini Fragogeorgi, Julian Daich, Eleftherios Fysikopoulos, Simon Lacroix, Gilles Doumont, Maria Georgiou, Dimitri Stanicki, Marcos Pita, Sophie Laurent, Penelope Bouziotis, Marisela Velez, George Loudos
Collagen scaffolds labelled with MRI and SPECT contrast agents for non-invasive imaging in bone tissue engineering
published pages: \"#PW 16 / 165 , ISSN: , DOI:
European Molecular Imaging Meeting - EMIM 2017 5-7 April 2017, Cologne, german 2019-11-29

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The information about "VIVOIMAG" are provided by the European Opendata Portal: CORDIS opendata.

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