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TUSUPO SIGNED

Tubular Supramolecular Polymers: A new class of therapeutic polymers

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EC-Contrib. €

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Project "TUSUPO" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF WARWICK 

Organization address
address: Kirby Corner Road - University House
city: COVENTRY
postcode: CV4 8UW
website: www.warwick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙692˙376 €
 EC max contribution 1˙692˙376 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF WARWICK UK (COVENTRY) coordinator 1˙692˙376.00

Map

 Project objective

This research programme will establish a new class of materials and develop them into functional devices for biomedical applications. We will design tubular supramolecular polymers, supramolecular polymer brushes (SPBs), based on the self-assembly of cyclic peptide – polymer conjugates. The synergy between the cyclic peptide, which directs the formation of the SPBs and the polymer conjugate, which provides functionality, will open the route to a wealth of new functional structures. We will build on our initial work and expand our research to generate new synthetic routes for the ligation of polymers to peptides, develop new protocols for the characterisation of the materials, and establish the mechanism of supramolecular polymerisation. This research programme will open new horizons in the fundamental understanding and production of supramolecular polymers. In particular, beyond the generation of new materials, the functionality of these systems may allow the development of supramolecular living polymers, a long-standing goal in polymer chemistry that is still elusive. The functionality and versatility of the SPBs obtained in this work open the route to a wealth of applications, and we will focus on one specific target: the fabrication of drug delivery vectors. We will exploit the unique combination of features presented by this new class of polymer therapeutics, such as multiple attachment points for one or more drug(s) / targeting ligands / markers, the ability to self-disassemble into smaller and easy-to-excrete components, and an elongated shape that enables diffusion and interaction with cells more efficiently than traditional globular delivery systems. We will study the pharmacology properties of the SPBs, including their stability, toxicity, mode of cell penetration and ability to deliver a single or a combination of bioactive agent(s) (in the case of concerted mechanisms).

 Publications

year authors and title journal last update
List of publications.
2018 Johannes C. Brendel, Joaquin Sanchis, Sylvain Catrouillet, Ewa Czuba, Moore Z. Chen, Benjamin M. Long, Cameron Nowell, Angus Johnston, Katrina A. Jolliffe, Sébastien Perrier
Secondary Self-Assembly of Supramolecular Nanotubes into Tubisomes and Their Activity on Cells
published pages: 16678-16682, ISSN: 1433-7851, DOI: 10.1002/anie.201808543
Angewandte Chemie International Edition 57/51 2020-04-01
2018 Huda Shaikh, Julia Y. Rho, Laura J. Macdougall, Pratik Gurnani, Andrew M. Lunn, Jie Yang, Steve Huband, Edward D. H. Mansfield, Raoul Peltier, Sebastien Perrier
Hydrogel and Organogel Formation by Hierarchical Self-Assembly of Cyclic Peptides Nanotubes
published pages: 19066-19074, ISSN: 0947-6539, DOI: 10.1002/chem.201804576
Chemistry - A European Journal 24/71 2020-04-01
2019 Qiao Song, Jie Yang, Stephen C. L. Hall, Pratik Gurnani, Sébastien Perrier
Pyridyl Disulfide Reaction Chemistry: An Efficient Strategy toward Redox-Responsive Cyclic Peptide–Polymer Conjugates
published pages: 1347-1352, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.9b00538
ACS Macro Letters 8/10 2020-04-01
2019 Matthias Hartlieb, Sylvain Catrouillet, Agnès Kuroki, Carlos Sanchez-Cano, Raoul Peltier, Sébastien Perrier
Stimuli-responsive membrane activity of cyclic-peptide–polymer conjugates
published pages: 5476-5483, ISSN: 2041-6520, DOI: 10.1039/c9sc00756c
Chemical Science 10/21 2020-04-01
2019 Julia Y. Rho, Henry Cox, Edward D. H. Mansfield, Sean H. Ellacott, Raoul Peltier, Johannes C. Brendel, Matthias Hartlieb, Thomas A. Waigh, Sébastien Perrier
Dual self-assembly of supramolecular peptide nanotubes to provide stabilisation in water
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-12586-8
Nature Communications 10/1 2020-04-01
2016 Sylvain Catrouillet, Johannes C. Brendel, Sophie Larnaudie, Tammie Barlow, Katrina A. Jolliffe, Sébastien Perrier
Tunable Length of Cyclic Peptide–Polymer Conjugate Self-Assemblies in Water
published pages: 1119-1123, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.6b00586
ACS Macro Letters 5/10 2020-04-01
2017 Sophie C. Larnaudie, Johannes C. Brendel, Katrina A. Jolliffe, Sébastien Perrier
pH-Responsive, Amphiphilic Core–Shell Supramolecular Polymer Brushes from Cyclic Peptide–Polymer Conjugates
published pages: 1347-1351, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.7b00728
ACS Macro Letters 6/12 2020-04-01
2018 Edward D. H. Mansfield, Matthias Hartlieb, Sylvain Catrouillet, Julia Y. Rho, Sophie C. Larnaudie, Sarah E. Rogers, Joaquin Sanchis, Johannes C. Brendel, Sébastien Perrier
Systematic study of the structural parameters affecting the self-assembly of cyclic peptide–poly(ethylene glycol) conjugates
published pages: 6320-6326, ISSN: 1744-683X, DOI: 10.1039/C8SM01133H
Soft Matter 14/30 2020-04-01
2018 Sophie C. Larnaudie, Joaquin Sanchis, Tri-Hung Nguyen, Raoul Peltier, Sylvain Catrouillet, Johannes C. Brendel, Christopher J.H. Porter, Katrina A. Jolliffe, Sébastien Perrier
Cyclic peptide-poly(HPMA) nanotubes as drug delivery vectors: In vitro assessment, pharmacokinetics and biodistribution
published pages: 570-582, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2018.03.047
Biomaterials 178 2020-04-01
2017 Sophie C. Larnaudie, Johannes C. Brendel, Isolda Romero-Canelón, Carlos Sanchez-Cano, Sylvain Catrouillet, Joaquin Sanchis, James P. C. Coverdale, Ji-Inn Song, Abraha Habtemariam, Peter J. Sadler, Katrina A. Jolliffe, Sébastien Perrier
Cyclic Peptide–Polymer Nanotubes as Efficient and Highly Potent Drug Delivery Systems for Organometallic Anticancer Complexes
published pages: 239-247, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.7b01491
Biomacromolecules 19/1 2020-04-01
2018 Jason G. Binfield, Johannes C. Brendel, Neil R. Cameron, Ahmed M. Eissa, Sébastien Perrier
Imaging Proton Transport in Giant Vesicles through Cyclic Peptide-Polymer Conjugate Nanotube Transmembrane Ion Channels
published pages: 1700831, ISSN: 1022-1336, DOI: 10.1002/marc.201700831
Macromolecular Rapid Communications 2020-04-01
2016 Moraes, J.; Peltier, R.; Gody, G.; Blum, M.; Recalcati, S.; Klok, H.-H.; Perrier, S.
Influence of block versus random monomer distribution on the cellular uptake of hydrophilic copolymers
published pages: , ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.6b00652
ACS Macro Lett 2020-04-01
2017 Julia Y. Rho, Johannes C. Brendel, Liam R. MacFarlane, Edward D. H. Mansfield, Raoul Peltier, Sarah Rogers, Matthias Hartlieb, Sébastien Perrier
Probing the Dynamic Nature of Self-Assembling Cyclic Peptide-Polymer Nanotubes in Solution and in Mammalian Cells
published pages: 1704569, ISSN: 1616-301X, DOI: 10.1002/adfm.201704569
Advanced Functional Materials 2020-04-01

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