Explore the words cloud of the GLYCO-TOOLS project. It provides you a very rough idea of what is the project "GLYCO-TOOLS" about.
The following table provides information about the project.
UNIVERSITY OF BRISTOL
|Coordinator Country||United Kingdom [UK]|
|Total cost||1˙986˙356 €|
|EC max contribution||1˙986˙356 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-07-01 to 2020-06-30|
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|1||UNIVERSITY OF BRISTOL||UK (BRISTOL)||coordinator||1˙986˙356.00|
Cell surface carbohydrates play key roles in cell recognition mechanisms. O-glycosylation is a ubiquitous post-translational modification that is highly dynamic and responsive to cellular stimuli through the action of cycling enzymes. Expression of specific O-glycans is linked to changes in gene expression in, for example, inflammatory bowel disease, cystic fibrosis and several types of cancer.
Protein-carbohydrate interactions typically exhibit high specificity and weak affinities toward their carbohydrate ligand. This low affinity is compensated in nature by the architecture of the protein, the host presenting the carbohydrate ligands in a multivalent manner or as clusters on the cell or mucosal surface. This effect is known as the multivalency or “cluster–glycoside effect” and has been well documented for lectin–carbohydrate interactions as increasing ligand affinity and selectivity. The fundamental understanding of these glycosylation patterns at molecular and functional levels will allow mechanisms associated with bacterial-host interactions, bowel disease and several cancers to be defined, which will facilitate the identification of effective treatments and diagnostics for these conditions in due course.
This is a multidisciplinary project involving synthetic organic and inorganic chemistry, enzymology and glycobiology. The proposal centres on the development of expedient synthetic and chemo-enzymatic methodologies for the preparation of novel multivalent O-glycan probes that will be used in the screening of O-glycosylation-linked interactions in health and in disease. These studies will help us understand the parameters controlling the combinatorial diversity of O-glycans and the implications of such diversity on receptor binding and subsequent intracellular signalling, which in turn will lead us to the development of new glycan-based diagnostic tools and therapeutics.
|year||authors and title||journal||last update|
I. Sittel, M. C. Galan
Imidazolium-labeled glycosides as probes to harness glycosyltransferase activity in human breast milk
published pages: 3575-3579, ISSN: 1477-0520, DOI: 10.1039/C7OB00550D
|Org. Biomol. Chem. 15/17||2019-06-06|
Abhijit Sau, M. Carmen Galan
Palladium-Catalyzed ?-Stereoselective O -Glycosylation of O(3)-Acylated Glycals
published pages: 2857-2860, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.7b01092
|Organic Letters 19/11||2019-06-06|
Stephen A. Hill, David. Benito-Alifonso, David J. Morgan, Sean A. Davis, Monica Berry, M. Carmen Galan
Three-minute synthesis of sp 3 nanocrystalline carbon dots as non-toxic fluorescent platforms for intracellular delivery
published pages: 18630-18634, ISSN: 2040-3364, DOI: 10.1039/C6NR07336K
David Benito-Alifonso, Shirley Tremell, Joanna C. Sadler, Monica Berry, M. Carmen Galan
Imidazolium-tagged glycan probes for non-covalent labeling of live cells
published pages: 4906-4909, ISSN: 1359-7345, DOI: 10.1039/C5CC10040B
|Chem. Commun. 52/27||2019-06-06|
Alexander S. Henderson, John F. Bower, M. Carmen Galan
Carbohydrates as enantioinduction components in stereoselective catalysis
published pages: 4008-4017, ISSN: 1477-0520, DOI: 10.1039/C6OB00368K
|Org. Biomol. Chem. 14/17||2019-06-06|
Abhijit Sau, Ryan Williams, Carlos Palo-Nieto, Antonio Franconetti, Sandra Medina, M. Carmen Galan
Palladium-Catalyzed Direct Stereoselective Synthesis of Deoxyglycosides from Glycals
published pages: 3640-3644, ISSN: 1433-7851, DOI: 10.1002/anie.201612071
|Angewandte Chemie International Edition 56/13||2019-06-06|
Stephen Hill, M Carmen Galan
Fluorescent carbon dots from mono- and polysaccharides: synthesis, properties and applications
published pages: 675-693, ISSN: 1860-5397, DOI: 10.3762/bjoc.13.67
|Beilstein Journal of Organic Chemistry 13||2019-06-06|
Steven T. G. Street, Donovan N. Chin, Gregory J. Hollingworth, Monica Berry, Juan C. Morales, M. Carmen Galan
Divalent Naphthalene Diimide Ligands Display High Selectivity for the Human Telomeric G-quadruplex in K + Buffer
published pages: 6953-6958, ISSN: 0947-6539, DOI: 10.1002/chem.201700140
|Chemistry - A European Journal 23/29||2019-06-06|
Sandra Medina, Matthew J. Harper, Edward I. Balmond, Silvia Miranda, Giacomo E. M. Crisenza, Diane M. Coe, Eoghan M. McGarrigle, M. Carmen Galan
Stereoselective Glycosylation of 2-Nitrogalactals Catalyzed by a Bifunctional Organocatalyst
published pages: 4222-4225, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.6b01962
|Organic Letters 18/17||2019-06-06|
Thomas A. Swift, Marta Duchi, Stephen A. Hill, David Benito-Alifonso, Robert L. Harniman, Sadiyah Sheikh, Sean A. Davis, Annela M. Seddon, Heather M. Whitney, M. Carmen Galan, Thomas A. A. Oliver
Surface functionalisation significantly changes the physical and electronic properties of carbon nano-dots
published pages: 13908-13912, ISSN: 2040-3364, DOI: 10.1039/c8nr03430c
Stephen A. Hill, David Benito-Alifonso, Sean A. Davis, David J. Morgan, Monica Berry, M. Carmen Galan
Practical Three-Minute Synthesis of Acid-Coated Fluorescent Carbon Dots with Tuneable Core Structure
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-29674-2
|Scientific Reports 8/1||2019-04-13|
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