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GLYCO-TOOLS SIGNED

Bio-Inspired Tools for Glycoscience

Total Cost €

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EC-Contrib. €

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Partnership

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 GLYCO-TOOLS project word cloud

Explore the words cloud of the GLYCO-TOOLS project. It provides you a very rough idea of what is the project "GLYCO-TOOLS" about.

combinatorial    multivalency    patterns    toward    glycobiology    functional    turn    dynamic    course    health    compensated    cystic    glycosylation    modification    architecture    preparation    selectivity    subsequent    cellular    cancers    bacterial    affinity    multivalent    screening    specificity    mechanisms    levels    affinities    treatments    action    lectin    effect    protein    play    carbohydrate    ligands    enzymes    presenting    signalling    organic    diagnostic    expression    probes    recognition    disease    ligand    therapeutics    enzymatic    inorganic    tools    intracellular    receptor    ubiquitous    manner    responsive    cell    surface    nature    identification    clusters    linked    diagnostics    understand    multidisciplinary    fibrosis    centres    weak    cancer    bowel    roles    expedient    glycan    synthetic    glycans    glycoside    exhibit    interactions    fundamental    inflammatory    stimuli    types    binding    enzymology    carbohydrates    chemistry    host    documented    diversity    mucosal    chemo    gene    post    molecular    implications    cycling    translational    cluster   

Project "GLYCO-TOOLS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://galanresearch.com
 Total cost 1˙986˙356 €
 EC max contribution 1˙986˙356 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 1˙986˙356.00

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 Project objective

Cell surface carbohydrates play key roles in cell recognition mechanisms. O-glycosylation is a ubiquitous post-translational modification that is highly dynamic and responsive to cellular stimuli through the action of cycling enzymes. Expression of specific O-glycans is linked to changes in gene expression in, for example, inflammatory bowel disease, cystic fibrosis and several types of cancer.

Protein-carbohydrate interactions typically exhibit high specificity and weak affinities toward their carbohydrate ligand. This low affinity is compensated in nature by the architecture of the protein, the host presenting the carbohydrate ligands in a multivalent manner or as clusters on the cell or mucosal surface. This effect is known as the multivalency or “cluster–glycoside effect” and has been well documented for lectin–carbohydrate interactions as increasing ligand affinity and selectivity. The fundamental understanding of these glycosylation patterns at molecular and functional levels will allow mechanisms associated with bacterial-host interactions, bowel disease and several cancers to be defined, which will facilitate the identification of effective treatments and diagnostics for these conditions in due course.

This is a multidisciplinary project involving synthetic organic and inorganic chemistry, enzymology and glycobiology. The proposal centres on the development of expedient synthetic and chemo-enzymatic methodologies for the preparation of novel multivalent O-glycan probes that will be used in the screening of O-glycosylation-linked interactions in health and in disease. These studies will help us understand the parameters controlling the combinatorial diversity of O-glycans and the implications of such diversity on receptor binding and subsequent intracellular signalling, which in turn will lead us to the development of new glycan-based diagnostic tools and therapeutics.

 Publications

year authors and title journal last update
List of publications.
2017 I. Sittel, M. C. Galan
Imidazolium-labeled glycosides as probes to harness glycosyltransferase activity in human breast milk
published pages: 3575-3579, ISSN: 1477-0520, DOI: 10.1039/C7OB00550D
Org. Biomol. Chem. 15/17 2019-06-06
2017 Abhijit Sau, M. Carmen Galan
Palladium-Catalyzed ?-Stereoselective O -Glycosylation of O(3)-Acylated Glycals
published pages: 2857-2860, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.7b01092
Organic Letters 19/11 2019-06-06
2016 Stephen A. Hill, David. Benito-Alifonso, David J. Morgan, Sean A. Davis, Monica Berry, M. Carmen Galan
Three-minute synthesis of sp 3 nanocrystalline carbon dots as non-toxic fluorescent platforms for intracellular delivery
published pages: 18630-18634, ISSN: 2040-3364, DOI: 10.1039/C6NR07336K
Nanoscale 8/44 2019-06-06
2016 David Benito-Alifonso, Shirley Tremell, Joanna C. Sadler, Monica Berry, M. Carmen Galan
Imidazolium-tagged glycan probes for non-covalent labeling of live cells
published pages: 4906-4909, ISSN: 1359-7345, DOI: 10.1039/C5CC10040B
Chem. Commun. 52/27 2019-06-06
2016 Alexander S. Henderson, John F. Bower, M. Carmen Galan
Carbohydrates as enantioinduction components in stereoselective catalysis
published pages: 4008-4017, ISSN: 1477-0520, DOI: 10.1039/C6OB00368K
Org. Biomol. Chem. 14/17 2019-06-06
2017 Abhijit Sau, Ryan Williams, Carlos Palo-Nieto, Antonio Franconetti, Sandra Medina, M. Carmen Galan
Palladium-Catalyzed Direct Stereoselective Synthesis of Deoxyglycosides from Glycals
published pages: 3640-3644, ISSN: 1433-7851, DOI: 10.1002/anie.201612071
Angewandte Chemie International Edition 56/13 2019-06-06
2017 Stephen Hill, M Carmen Galan
Fluorescent carbon dots from mono- and polysaccharides: synthesis, properties and applications
published pages: 675-693, ISSN: 1860-5397, DOI: 10.3762/bjoc.13.67
Beilstein Journal of Organic Chemistry 13 2019-06-06
2017 Steven T. G. Street, Donovan N. Chin, Gregory J. Hollingworth, Monica Berry, Juan C. Morales, M. Carmen Galan
Divalent Naphthalene Diimide Ligands Display High Selectivity for the Human Telomeric G-quadruplex in K + Buffer
published pages: 6953-6958, ISSN: 0947-6539, DOI: 10.1002/chem.201700140
Chemistry - A European Journal 23/29 2019-06-06
2016 Sandra Medina, Matthew J. Harper, Edward I. Balmond, Silvia Miranda, Giacomo E. M. Crisenza, Diane M. Coe, Eoghan M. McGarrigle, M. Carmen Galan
Stereoselective Glycosylation of 2-Nitrogalactals Catalyzed by a Bifunctional Organocatalyst
published pages: 4222-4225, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.6b01962
Organic Letters 18/17 2019-06-06
2018 Thomas A. Swift, Marta Duchi, Stephen A. Hill, David Benito-Alifonso, Robert L. Harniman, Sadiyah Sheikh, Sean A. Davis, Annela M. Seddon, Heather M. Whitney, M. Carmen Galan, Thomas A. A. Oliver
Surface functionalisation significantly changes the physical and electronic properties of carbon nano-dots
published pages: 13908-13912, ISSN: 2040-3364, DOI: 10.1039/c8nr03430c
Nanoscale 10/29 2019-04-13
2018 Stephen A. Hill, David Benito-Alifonso, Sean A. Davis, David J. Morgan, Monica Berry, M. Carmen Galan
Practical Three-Minute Synthesis of Acid-Coated Fluorescent Carbon Dots with Tuneable Core Structure
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-29674-2
Scientific Reports 8/1 2019-04-13

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