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BlaC E-assay

Portable electrochemical assay system for on-chip quantitative estimation of bladder cancer biomarkers in real samples

Total Cost €

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EC-Contrib. €

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Partnership

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Project "BlaC E-assay" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BATH 

Organization address
address: CLAVERTON DOWN
city: BATH
postcode: BA2 7AY
website: http://www.bath.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://go.bath.ac.uk/biosensors
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-10-05   to  2017-10-04

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BATH UK (BATH) coordinator 195˙454.00

Map

 Project objective

Cancer is a leading cause of death worldwide and the best approaches to improve cancer survival rate is to diagnose it at an early stage. In spite of the rapid explosion of new technology platforms, traditional optical ELISA is used in clinical practice, which is laborious, time-consuming, require large sample volume and suffer from low sensitivity. On the other hand, recently proposed electrochemical sensors which promise easy operation, accuracy, high sensitivity, low cost and compact size mainly suffer from background signals, non-specificity and selectivity in clinical samples. Therefore, there is an urgent need to solve the key issues in the development of clinically relevant and commercially viable technologies that enable screening of high-risk individuals for cancer at an early stage. The proposed program is to develop a reliable point-of-care (POC) diagnostic system based on a multidisciplinary approach of integrated microfluidic and electrochemistry for multiple biomarker detection in clinical samples. The proposal aims at finding solutions for key issues of non-specificity, sensitivity and selectivity in clinical samples for sensitive and multiplexed detection. The proposal will address the above mentioned challenges, via separation of assay chamber and detection chamber with innovative surface chemistry and microfluidic design with electrochemical detection techniques. Work will be focused on bladder cancer as a test model to solve the above mentioned issues. The proposed device will be of bench top size and have capabilities to detect a panel of 3 or more biomarkers simultaneously. The successful outcome of the project will result in high impact publications, technology know-how and IP, which will be used to design and develop a prototype device. A secondment at Applied Enzyme Technology Ltd, Gwent Group (GWENT) will be used to study optimization of sensor shelf life and to ensure the developed system meets industrial standards.

 Publications

year authors and title journal last update
List of publications.
2018 Sunil K. Arya, Pedro Estrela
Electrochemical ELISA-based platform for bladder cancer protein biomarker detection in urine
published pages: 620-627, ISSN: 0956-5663, DOI: 10.1016/j.bios.2018.07.003
Biosensors and Bioelectronics 117 2019-06-13
2018 Pavel Zhurauski, Sunil K. Arya, Pawan Jolly, Christian Tiede, Darren C. Tomlinson, Paul Ko Ferrigno, Pedro Estrela
Sensitive and selective Affimer-functionalised interdigitated electrode-based capacitive biosensor for Her4 protein tumour biomarker detection
published pages: 1-8, ISSN: 0956-5663, DOI: 10.1016/j.bios.2018.02.041
Biosensors and Bioelectronics 108 2019-06-13
2018 Naveen K. Singh, Sunil K. Arya, Pedro Estrela, Pranab Goswami
Capacitive malaria aptasensor using Plasmodium falciparum glutamate dehydrogenase as target antigen in undiluted human serum
published pages: 246-252, ISSN: 0956-5663, DOI: 10.1016/j.bios.2018.06.022
Biosensors and Bioelectronics 117 2019-06-13
2018 Sunil Arya, Pedro Estrela
Recent Advances in Enhancement Strategies for Electrochemical ELISA-Based Immunoassays for Cancer Biomarker Detection
published pages: 2010, ISSN: 1424-8220, DOI: 10.3390/s18072010
Sensors 18/7 2019-06-13
2018 Sunil K. Arya, Pavel Zhurauski, Pawan Jolly, Marina R. Batistuti, Marcelo Mulato, Pedro Estrela
Capacitive aptasensor based on interdigitated electrode for breast cancer detection in undiluted human serum
published pages: 106-112, ISSN: 0956-5663, DOI: 10.1016/j.bios.2017.11.013
Biosensors and Bioelectronics 102 2019-06-13
2017 Sunil K. Arya, Pedro Estrela
Electrochemical immunosensor for tumor necrosis factor-alpha detection in undiluted serum
published pages: 125-131, ISSN: 1046-2023, DOI: 10.1016/j.ymeth.2016.12.001
Methods 116 2019-06-13

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