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SYNPT

The role of autophagy in presynaptic protein turnover

Total Cost €

0

EC-Contrib. €

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Partnership

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Project "SYNPT" data sheet

The following table provides information about the project.

Coordinator
FORSCHUNGSVERBUND BERLIN EV 

Organization address
address: RUDOWER CHAUSSEE 17
city: BERLIN
postcode: 12489
website: www.fv-berlin.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2017-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FORSCHUNGSVERBUND BERLIN EV DE (BERLIN) coordinator 159˙460.00

Map

 Project objective

Neuronal communication primarily occurs at synapses. Recent studies have suggested a key role for protein synthesis and degradation in the regulation of synaptic structure, function and plasticity by changing the abundance of select synaptic proteins in a spatially confined manner. Remodeling of the synaptic proteome is accomplished by, for example, regulated degradation via the ubiquitin proteasome system or by autophagy. Autophagy has been shown to modulate synaptic vesicle numbers and neurotransmission, yet its exact role in the regulation of synaptic function is poorly understood. The proposed project aims at the dissection of the role of autophagy in synaptic protein turnover. Using combined genetic, biochemical, molecular and cellular biology approaches as well as cutting-edge imaging in neurons I will identify presynaptic proteins that are regulated by autophagy and will define the contribution of autophagy to synapse composition and function. Furthermore, I will determine which mechanisms underlie the selective targeting of presynaptic proteins to the autophagy pathway. Taken together these studies will contribute fundamental knowledge about autophagy in neurons and will provide new insights for understanding how autophagy contributes to synaptic plasticity and protein degradation in health and disease.

 Publications

year authors and title journal last update
List of publications.
2017 Natalia L. Kononenko, Gala A. Claßen, Marijn Kuijpers, Dmytro Puchkov, Tanja Maritzen, Aleksandra Tempes, Anna R. Malik, Agnieszka Skalecka, Sujoy Bera, Jacek Jaworski, Volker Haucke
Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration
published pages: 14819, ISSN: 2041-1723, DOI: 10.1038/ncomms14819
Nature Communications 8 2019-07-23

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