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BioMASCE SIGNED

Biophysical Manipulation of Adult Stem Cell Epigenetics (BioMASCE) By Cell-Penetrating Nanoneedle Substrates

Total Cost €

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EC-Contrib. €

0

Partnership

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 BioMASCE project word cloud

Explore the words cloud of the BioMASCE project. It provides you a very rough idea of what is the project "BioMASCE" about.

imperial    undergo    cross    property    therapeutic    membrane    engineering    clinical    stem    porous    shape    base    lineage    organisation    cell    differentiation    tool    silicon    shown    nucleus    sectoral    edge    multidisciplinary    mechanics    types    capacity    manipulating    regulate    exploited    parallel    psi    penetrate    benefit    interfere    academic    status    leverages    epigenetic    coding    therapies    source    industrial    material    class    physical    human    personal    porosity    enhanced    basic    network    size    inherent    nuclear    mesenchymal    hmsc    interestingly    protection    rnas    coupled    uk    stevens    mechanisms    nanoneedles    hmscs    platform    ing    utilising    biology    nns    biomedical    college    regenerative    london    cutting    subsequent    training    cells    discovery    stimulating    secondment    translation    contacts    manipulate    dna    penetration    translate    commercialisation    icl    efficacy    intellectual    group   

Project "BioMASCE" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.imperial.ac.uk/people/s.crowder
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2018-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Human mesenchymal stem cells (hMSCs) are a promising cell source for regenerative therapies. In part, their capacity for multi-lineage differentiation and subsequent therapeutic efficacy is controlled by the epigenetic status of the DNA. The Stevens Group at Imperial College London (ICL) has recently developed a novel material platform of porous silicon (pSi) nanoneedles (nNs) that penetrate the cell membrane, stimulating physical changes in the nucleus. Interestingly, nuclear mechanics and shape parameters have been shown to control epigenetic status in various cell types, but this remains under-investigated in hMSC. Therefore, in the present study, pSi nNs will be used to manipulate hMSC nuclear size and shape, as well as the resulting epigenetic status, as a means to identify novel mechanisms for enhancing differentiation capacity. The inherent porosity of the nNs, coupled with their ability for cell penetration, will be exploited as a delivery tool for a cutting-edge class of non-coding RNAs into hMSCs to interfere with, and further regulate, epigenetic status and resulting therapeutic potential. This discovery-driven project leverages a one-of-a-kind engineering tool for investigating and manipulating hMSC behaviour. In parallel, the applicant has proposed to undergo a secondment to a UK-based, non-academic partner organisation to enhance his knowledge of intellectual property protection, technology development, and product commercialisation in order to translate his research findings for clinical benefit. The applicant will increase his knowledge base during the project, creating new contacts in his personal network, as well as for the Stevens Group and ICL. This project represents a multidisciplinary, cutting-edge approach to stem cell biology and biomedical engineering, utilising cross-sectoral collaboration for enhanced training and potential for industrial translation of basic research findings.

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The information about "BIOMASCE" are provided by the European Opendata Portal: CORDIS opendata.

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