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BioMASCE SIGNED

Biophysical Manipulation of Adult Stem Cell Epigenetics (BioMASCE) By Cell-Penetrating Nanoneedle Substrates

Total Cost €

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EC-Contrib. €

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Partnership

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 BioMASCE project word cloud

Explore the words cloud of the BioMASCE project. It provides you a very rough idea of what is the project "BioMASCE" about.

physical    imperial    icl    class    organisation    benefit    translate    silicon    capacity    platform    protection    regenerative    status    inherent    discovery    uk    cutting    translation    epigenetic    size    biomedical    commercialisation    personal    rnas    human    property    types    cross    regulate    stem    therapies    training    interfere    parallel    engineering    mesenchymal    edge    penetration    mechanics    ing    penetrate    sectoral    hmscs    stevens    nuclear    nucleus    enhanced    efficacy    shape    cell    coding    academic    porous    exploited    college    differentiation    basic    dna    base    stimulating    manipulating    network    psi    subsequent    coupled    intellectual    group    interestingly    leverages    biology    mechanisms    undergo    clinical    utilising    secondment    nanoneedles    tool    porosity    nns    therapeutic    cells    manipulate    contacts    multidisciplinary    shown    hmsc    industrial    lineage    source    membrane    london    material   

Project "BioMASCE" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.imperial.ac.uk/people/s.crowder
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2018-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Human mesenchymal stem cells (hMSCs) are a promising cell source for regenerative therapies. In part, their capacity for multi-lineage differentiation and subsequent therapeutic efficacy is controlled by the epigenetic status of the DNA. The Stevens Group at Imperial College London (ICL) has recently developed a novel material platform of porous silicon (pSi) nanoneedles (nNs) that penetrate the cell membrane, stimulating physical changes in the nucleus. Interestingly, nuclear mechanics and shape parameters have been shown to control epigenetic status in various cell types, but this remains under-investigated in hMSC. Therefore, in the present study, pSi nNs will be used to manipulate hMSC nuclear size and shape, as well as the resulting epigenetic status, as a means to identify novel mechanisms for enhancing differentiation capacity. The inherent porosity of the nNs, coupled with their ability for cell penetration, will be exploited as a delivery tool for a cutting-edge class of non-coding RNAs into hMSCs to interfere with, and further regulate, epigenetic status and resulting therapeutic potential. This discovery-driven project leverages a one-of-a-kind engineering tool for investigating and manipulating hMSC behaviour. In parallel, the applicant has proposed to undergo a secondment to a UK-based, non-academic partner organisation to enhance his knowledge of intellectual property protection, technology development, and product commercialisation in order to translate his research findings for clinical benefit. The applicant will increase his knowledge base during the project, creating new contacts in his personal network, as well as for the Stevens Group and ICL. This project represents a multidisciplinary, cutting-edge approach to stem cell biology and biomedical engineering, utilising cross-sectoral collaboration for enhanced training and potential for industrial translation of basic research findings.

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The information about "BIOMASCE" are provided by the European Opendata Portal: CORDIS opendata.

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