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BioMASCE SIGNED

Biophysical Manipulation of Adult Stem Cell Epigenetics (BioMASCE) By Cell-Penetrating Nanoneedle Substrates

Total Cost €

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EC-Contrib. €

0

Partnership

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 BioMASCE project word cloud

Explore the words cloud of the BioMASCE project. It provides you a very rough idea of what is the project "BioMASCE" about.

hmsc    mechanisms    discovery    industrial    efficacy    penetrate    translation    manipulate    epigenetic    commercialisation    contacts    biomedical    group    lineage    ing    mesenchymal    translate    imperial    secondment    porosity    basic    utilising    stevens    types    cells    cutting    coding    silicon    capacity    coupled    london    intellectual    benefit    psi    edge    college    nucleus    academic    dna    regenerative    mechanics    tool    rnas    network    uk    therapeutic    size    nanoneedles    multidisciplinary    base    therapies    stem    leverages    enhanced    penetration    biology    porous    shown    human    engineering    property    membrane    sectoral    parallel    cross    class    platform    clinical    subsequent    material    undergo    hmscs    protection    interfere    physical    manipulating    interestingly    exploited    differentiation    training    personal    source    nuclear    nns    status    shape    cell    organisation    stimulating    inherent    icl    regulate   

Project "BioMASCE" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.imperial.ac.uk/people/s.crowder
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2018-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Human mesenchymal stem cells (hMSCs) are a promising cell source for regenerative therapies. In part, their capacity for multi-lineage differentiation and subsequent therapeutic efficacy is controlled by the epigenetic status of the DNA. The Stevens Group at Imperial College London (ICL) has recently developed a novel material platform of porous silicon (pSi) nanoneedles (nNs) that penetrate the cell membrane, stimulating physical changes in the nucleus. Interestingly, nuclear mechanics and shape parameters have been shown to control epigenetic status in various cell types, but this remains under-investigated in hMSC. Therefore, in the present study, pSi nNs will be used to manipulate hMSC nuclear size and shape, as well as the resulting epigenetic status, as a means to identify novel mechanisms for enhancing differentiation capacity. The inherent porosity of the nNs, coupled with their ability for cell penetration, will be exploited as a delivery tool for a cutting-edge class of non-coding RNAs into hMSCs to interfere with, and further regulate, epigenetic status and resulting therapeutic potential. This discovery-driven project leverages a one-of-a-kind engineering tool for investigating and manipulating hMSC behaviour. In parallel, the applicant has proposed to undergo a secondment to a UK-based, non-academic partner organisation to enhance his knowledge of intellectual property protection, technology development, and product commercialisation in order to translate his research findings for clinical benefit. The applicant will increase his knowledge base during the project, creating new contacts in his personal network, as well as for the Stevens Group and ICL. This project represents a multidisciplinary, cutting-edge approach to stem cell biology and biomedical engineering, utilising cross-sectoral collaboration for enhanced training and potential for industrial translation of basic research findings.

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The information about "BIOMASCE" are provided by the European Opendata Portal: CORDIS opendata.

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