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HRPCDMECH TERMINATED

Investigating how pathogen effector recognition by the host plant activates cell death

Total Cost €

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EC-Contrib. €

0

Partnership

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 HRPCDMECH project word cloud

Explore the words cloud of the HRPCDMECH project. It provides you a very rough idea of what is the project "HRPCDMECH" about.

security    shed    metacaspases    hypersensitive    patterns    cell    population    host    food    mcs    downstream    hr    proteolytic    protected    recognizes    circumvented    nutrients    effectors    water    synergistic    proteome    decapping    enhancement    cells    events    recognize    proteins    plants    diverse    pamps    immune    reverse    crops    detection    effector    earth    proteases    sustain    takes    modulate    sources    accompanied    parasitism    layer    infection    deployment    waxy    microbial    mrna    molecular    translation    suggest    strategy    eti    array    entering    considering    relies    strategies    highlighting    death    programmed    place    initiator    modulation    genetics    pcd    cuticular    rearrangements    temporal    pathogen    proteolysis    active    rna    epidermal    encounter    pathogens    event    walls    manner    selective    landscape    communities    pti    systematic    light    breaching    culminates    leads    plant    barrier    showed    protein    attempt    elusive    triggered    devastating    first    orchestrate    urgently    stomata    immunity    pattern    elucidate   

Project "HRPCDMECH" data sheet

The following table provides information about the project.

Coordinator
THE SAINSBURY LABORATORY 

Organization address
address: Norwich Research Park, Colney Lane
city: NORWICH
postcode: NR47UH
website: http://www.tsl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.slu.se/en/departments/plant-biology-forest-genetics/research/groups/panagiotis-moschou/research/
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2018-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE SAINSBURY LABORATORY UK (NORWICH) coordinator 183˙454.00

Map

 Project objective

Plants are rich sources of nutrients and water for diverse microbial communities. Some of these communities evolved parasitism as a strategy to access plant nutrients, with devastating results for crops. Plants are protected from infection by a waxy cuticular layer above the walls of epidermal cells. Would-be pathogens breaching this barrier, or entering via stomata, encounter an active plant immune system that specifically recognizes pathogens. Breaching leads to the deployment of two synergistic pathways that orchestrate immune responses. The first relies on the detection of pathogen-associated molecular patterns (PAMPs) and culminates in pattern-triggered immunity (PTI). When the first is circumvented a second array of responses takes place known as effector triggered immunity (ETI). In ETI, host factors known as R proteins recognize pathogen effectors, an event which is accompanied by the execution of a unique programmed cell death (PCD) type known as the hypersensitive response (HR). Although the initiator of the HR-PCD is known to depend on the formation of an effector-R complex, the downstream molecular events remain elusive. Previous results showed that particular proteases known as metacaspases (MCs) modulate HR-PCD, highlighting the importance of proteolysis and proteome rearrangements for HR-PCD modulation. I will attempt to shed light on the rearrangements of the HR-PCD proteome landscape, by studying processes that control it: selective RNA decapping and translation and proteolytic events, in a highly temporal manner using systematic approaches and reverse genetics. This project is expected to elucidate the importance of these processes and provide a detailed analysis of mRNA and protein level rearrangements during HR-PCD. In addition, this project will suggest strategies for enhancement of plant immunity against pathogens, which is urgently needed to sustain food security considering the ever growing earth’s population.

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