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HRPCDMECH TERMINATED

Investigating how pathogen effector recognition by the host plant activates cell death

Total Cost €

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EC-Contrib. €

0

Partnership

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 HRPCDMECH project word cloud

Explore the words cloud of the HRPCDMECH project. It provides you a very rough idea of what is the project "HRPCDMECH" about.

stomata    initiator    relies    entering    plants    proteases    pathogens    immunity    layer    effectors    crops    modulation    devastating    shed    eti    first    plant    highlighting    sustain    orchestrate    strategy    proteome    molecular    breaching    nutrients    proteins    considering    death    microbial    genetics    light    hypersensitive    immune    culminates    parasitism    programmed    reverse    temporal    leads    events    cuticular    enhancement    proteolytic    mrna    infection    manner    food    protected    detection    elusive    pathogen    circumvented    urgently    place    takes    protein    encounter    cells    event    earth    hr    walls    mcs    pamps    recognizes    pcd    security    accompanied    synergistic    communities    translation    showed    barrier    recognize    waxy    array    host    systematic    proteolysis    modulate    epidermal    elucidate    water    metacaspases    attempt    effector    active    selective    population    sources    rearrangements    diverse    patterns    pattern    downstream    cell    pti    suggest    deployment    rna    decapping    triggered    strategies    landscape   

Project "HRPCDMECH" data sheet

The following table provides information about the project.

Coordinator
THE SAINSBURY LABORATORY 

Organization address
address: Norwich Research Park, Colney Lane
city: NORWICH
postcode: NR47UH
website: http://www.tsl.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
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 Coordinator Country United Kingdom [UK]
 Project website https://www.slu.se/en/departments/plant-biology-forest-genetics/research/groups/panagiotis-moschou/research/
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-02-01   to  2018-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE SAINSBURY LABORATORY UK (NORWICH) coordinator 183˙454.00

Map

 Project objective

Plants are rich sources of nutrients and water for diverse microbial communities. Some of these communities evolved parasitism as a strategy to access plant nutrients, with devastating results for crops. Plants are protected from infection by a waxy cuticular layer above the walls of epidermal cells. Would-be pathogens breaching this barrier, or entering via stomata, encounter an active plant immune system that specifically recognizes pathogens. Breaching leads to the deployment of two synergistic pathways that orchestrate immune responses. The first relies on the detection of pathogen-associated molecular patterns (PAMPs) and culminates in pattern-triggered immunity (PTI). When the first is circumvented a second array of responses takes place known as effector triggered immunity (ETI). In ETI, host factors known as R proteins recognize pathogen effectors, an event which is accompanied by the execution of a unique programmed cell death (PCD) type known as the hypersensitive response (HR). Although the initiator of the HR-PCD is known to depend on the formation of an effector-R complex, the downstream molecular events remain elusive. Previous results showed that particular proteases known as metacaspases (MCs) modulate HR-PCD, highlighting the importance of proteolysis and proteome rearrangements for HR-PCD modulation. I will attempt to shed light on the rearrangements of the HR-PCD proteome landscape, by studying processes that control it: selective RNA decapping and translation and proteolytic events, in a highly temporal manner using systematic approaches and reverse genetics. This project is expected to elucidate the importance of these processes and provide a detailed analysis of mRNA and protein level rearrangements during HR-PCD. In addition, this project will suggest strategies for enhancement of plant immunity against pathogens, which is urgently needed to sustain food security considering the ever growing earth’s population.

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