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TANYFEEDNEURONS

Gliotransmission and shuttling of metabolic signals to feeding neuronal circuits by tanycytes

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 TANYFEEDNEURONS project word cloud

Explore the words cloud of the TANYFEEDNEURONS project. It provides you a very rough idea of what is the project "TANYFEEDNEURONS" about.

tools    genetic    cerebrospinal    purinergic    communication    arcuate    glial    borne    glia    network    little    metabolic    age    designed    intercellular    intake    lactate    treating    physiological    tanyfeedneurons    tanycyte    techniques    acute    cellular    neuronal    messenger    cells    insights    context    modulate    strategies    answering    csf    series    located    homeostasis    mouse    manipulations    neurons    tanycytes    brain    sense    experiments    functional    potentially    indicate    peptide    critical    nucleus    extracellular    food    hypothalamus    mechanisms    selective    anorexigenic    captured    blood    therapy    arh    parenchyma    death    therapeutic    interface    newly    energy    triphosphate    electrophysiological    influence    slices    disorders    leptin    presented    electrical    hypothalamic    release    obesity    additionally    diseases    neuron    interact    fluid    adenosine    redistribute    specialized    glucose    direct    signaling    transport    questions    atp    roles    metabolite    status   

Project "TANYFEEDNEURONS" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://hypothalamus.eu/fr/
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 185˙076.00

Map

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Project objective

Tanycytes are specialized hypothalamic glial cells located at the interface between blood, cerebrospinal fluid (CSF) and brain areas that control food intake. Little is known about their physiological roles. Recent studies indicate that tanycytes sense the extracellular glucose, release the intercellular messenger adenosine triphosphate (ATP) and the energy metabolite lactate, both of which can potentially modulate neuronal activity. Tanycytes also transport the blood-borne anorexigenic peptide leptin from the blood to the CSF and brain parenchyma. Understanding how this glia may be able to interact with neurons from the arcuate nucleus of the hypothalamus (ARH) that control food intake is critical to identify new cellular targets for the development of therapeutic strategies for treating metabolic disorders. Therefore, the series of experiments presented in the proposal are designed to determine how tanycytes may influence electrical activity of ARH neurons. More specifically, the project is based on answering the following questions: i) Does purinergic signaling in tanycytes modulate activity of ARH neurons? ii) Do tanycytes interact with ARH neurons through a metabolic network? iii) How do tanycytes redistribute captured leptin towards ARH neurons? Towards this end, I will use electrophysiological techniques in acute mouse brain slices and newly-developed genetic tools that allow selective manipulations of tanycyte signaling. Additionally, I propose to investigate how changes in metabolic status (e.g. obesity) may influence tanycyte-ARH neuron communication, providing new insights into functional mechanisms contributing to metabolic disorders. The TANYFEEDNEURONS project will provide direct evidence for tanycyte-neuron communication in the context of energy homeostasis and will identify tanycytes as potential therapy for metabolic disorders, which are age-related diseases and lead cause of death in Europe.

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The information about "TANYFEEDNEURONS" are provided by the European Opendata Portal: CORDIS opendata.

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