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TANYFEEDNEURONS

Gliotransmission and shuttling of metabolic signals to feeding neuronal circuits by tanycytes

Total Cost €

0

EC-Contrib. €

0

Partnership

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 TANYFEEDNEURONS project word cloud

Explore the words cloud of the TANYFEEDNEURONS project. It provides you a very rough idea of what is the project "TANYFEEDNEURONS" about.

hypothalamic    metabolite    food    transport    borne    acute    potentially    sense    presented    questions    neurons    fluid    cellular    located    homeostasis    hypothalamus    intercellular    glia    direct    neuron    series    status    glial    tanycytes    functional    little    communication    blood    signaling    brain    disorders    electrical    experiments    specialized    modulate    age    critical    purinergic    extracellular    interface    slices    leptin    neuronal    release    arh    atp    newly    csf    nucleus    metabolic    network    answering    roles    techniques    anorexigenic    context    messenger    indicate    therapy    strategies    lactate    tanycyte    captured    intake    tools    electrophysiological    additionally    mechanisms    parenchyma    genetic    cerebrospinal    energy    triphosphate    glucose    mouse    obesity    selective    insights    therapeutic    designed    peptide    manipulations    arcuate    treating    physiological    tanyfeedneurons    diseases    redistribute    adenosine    cells    death    influence    interact   

Project "TANYFEEDNEURONS" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://hypothalamus.eu/fr/
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 185˙076.00

Map

 Project objective

Tanycytes are specialized hypothalamic glial cells located at the interface between blood, cerebrospinal fluid (CSF) and brain areas that control food intake. Little is known about their physiological roles. Recent studies indicate that tanycytes sense the extracellular glucose, release the intercellular messenger adenosine triphosphate (ATP) and the energy metabolite lactate, both of which can potentially modulate neuronal activity. Tanycytes also transport the blood-borne anorexigenic peptide leptin from the blood to the CSF and brain parenchyma. Understanding how this glia may be able to interact with neurons from the arcuate nucleus of the hypothalamus (ARH) that control food intake is critical to identify new cellular targets for the development of therapeutic strategies for treating metabolic disorders. Therefore, the series of experiments presented in the proposal are designed to determine how tanycytes may influence electrical activity of ARH neurons. More specifically, the project is based on answering the following questions: i) Does purinergic signaling in tanycytes modulate activity of ARH neurons? ii) Do tanycytes interact with ARH neurons through a metabolic network? iii) How do tanycytes redistribute captured leptin towards ARH neurons? Towards this end, I will use electrophysiological techniques in acute mouse brain slices and newly-developed genetic tools that allow selective manipulations of tanycyte signaling. Additionally, I propose to investigate how changes in metabolic status (e.g. obesity) may influence tanycyte-ARH neuron communication, providing new insights into functional mechanisms contributing to metabolic disorders. The TANYFEEDNEURONS project will provide direct evidence for tanycyte-neuron communication in the context of energy homeostasis and will identify tanycytes as potential therapy for metabolic disorders, which are age-related diseases and lead cause of death in Europe.

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