Opendata, web and dolomites

CylcoRu4PACT TERMINATED

Cyclometallated ruthenium complexes for photo-activated chemotherapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 CylcoRu4PACT project word cloud

Explore the words cloud of the CylcoRu4PACT project. It provides you a very rough idea of what is the project "CylcoRu4PACT" about.

excited    reactions    carbon    irradiation    model    maximizing    released    visible    consist    grounds    tissues    hypoxic    too    chemotherapeutic    overcome    penetrates    locally    window    photochemotherapeutic    cell    treatments    metal    wavelengths    ligand    determined    cytotoxicity    tumours    hindering    polypyridyl    alternative    shift    vitro    minimizing    recover    clinic    dark    tumour    efficacy    therapy    chemotherapy    compounds    concentration    synthesized    modifies    sterically    limit    cancer    oxygen    sensitive    prodrugs    photochemical    phototherapy    biological    treatment    light    complexes    red    quenches    concentrations    photoreactivity    efficient    occurring    wavelength    human    photosubstitution    lines    keeping    toxicity    stand    ruthenium    anticancer    fails    hard    containing    absorption    measured    patient    optimally    usually    bond    curing    cyclometallated    groups    synthesize    energy    compound    photodynamic    cyclometallation    introduce    place   

Project "CylcoRu4PACT" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT LEIDEN 

Organization address
address: RAPENBURG 70
city: LEIDEN
postcode: 2311 EZ
website: www.universiteitleiden.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website https://www.universiteitleiden.nl/en/staffmembers/sylvestre-bonnet
 Total cost 165˙598 €
 EC max contribution 165˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT LEIDEN NL (LEIDEN) coordinator 165˙598.00

Map

 Project objective

Chemotherapy is efficient in curing cancer, but most treatments are very hard to stand for the patient, and side effects limit treatment efficacy. Phototherapy is a promising alternative, where the toxicity of a light-sensitive chemotherapeutic compound is locally released upon visible light irradiation of the compound-containing tumour. Photodynamic therapy is already available in the clinic for oxygen-rich tumours; however, it fails when the oxygen concentration at the place of irradiation is too low. In this project I propose to synthesize new ruthenium-based photochemotherapeutic compounds containing cyclometallated ligand, and to test them in an in vitro model of hypoxic cancer. The presence of a carbon-metal bond is known to shift the light absorption properties of ruthenium polypyridyl complexes towards the photodynamic window, a wavelength range where light penetrates optimally into biological tissues. However, cyclometallation usually quenches the ligand photosubstitution properties of ruthenium compounds because it strongly modifies the energy of their excited states. In this project, I will introduce sterically hindering groups on the cyclometallated ligand to recover photoreactivity of the complexes while keeping light absorption at high wavelengths. The challenges of this project consist on the one hand in achieving efficient ligand photosubstitution reactions with cyclometallated ruthenium compounds, and on the other hand in minimizing the cytotoxicity in the dark while maximizing cytotoxicity after red light irradiation at low oxygen concentrations. The ruthenium prodrugs will be synthesized, their photochemical properties will be measured, and their cytotoxicity against human cancer cell lines will be determined in an in vitro model of hypoxic cancer. This project will set new grounds in the treatment of hypoxic tumours and propose a new way to overcome side effects occurring in traditional anticancer chemotherapy.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CYLCORU4PACT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "CYLCORU4PACT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

BirthControlEnvirons (2019)

Contraception meets the environment: everyday contraceptive practices, politics, and futures in a toxic age

Read More  

MarshFlux (2020)

The effect of future global climate and land-use change on greenhouse gas fluxes and microbial processes in salt marshes

Read More  

VINCI (2020)

The Value of Information and Choice to Improve Control.

Read More