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CylcoRu4PACT TERMINATED

Cyclometallated ruthenium complexes for photo-activated chemotherapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CylcoRu4PACT project word cloud

Explore the words cloud of the CylcoRu4PACT project. It provides you a very rough idea of what is the project "CylcoRu4PACT" about.

groups    containing    patient    absorption    introduce    stand    concentrations    sterically    treatments    recover    compound    metal    determined    polypyridyl    shift    cytotoxicity    synthesize    irradiation    hypoxic    reactions    chemotherapeutic    wavelength    wavelengths    hindering    released    excited    curing    occurring    compounds    clinic    alternative    biological    locally    therapy    phototherapy    energy    photosubstitution    overcome    concentration    human    oxygen    cell    light    ruthenium    cancer    consist    maximizing    anticancer    ligand    chemotherapy    complexes    keeping    dark    penetrates    minimizing    measured    photochemical    visible    fails    window    cyclometallation    prodrugs    too    photochemotherapeutic    efficacy    limit    tumours    optimally    toxicity    carbon    photodynamic    place    efficient    grounds    quenches    cyclometallated    hard    lines    photoreactivity    red    treatment    synthesized    tumour    bond    sensitive    usually    vitro    model    tissues    modifies   

Project "CylcoRu4PACT" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT LEIDEN 

Organization address
address: RAPENBURG 70
city: LEIDEN
postcode: 2311 EZ
website: www.universiteitleiden.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website https://www.universiteitleiden.nl/en/staffmembers/sylvestre-bonnet
 Total cost 165˙598 €
 EC max contribution 165˙598 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT LEIDEN NL (LEIDEN) coordinator 165˙598.00

Map

 Project objective

Chemotherapy is efficient in curing cancer, but most treatments are very hard to stand for the patient, and side effects limit treatment efficacy. Phototherapy is a promising alternative, where the toxicity of a light-sensitive chemotherapeutic compound is locally released upon visible light irradiation of the compound-containing tumour. Photodynamic therapy is already available in the clinic for oxygen-rich tumours; however, it fails when the oxygen concentration at the place of irradiation is too low. In this project I propose to synthesize new ruthenium-based photochemotherapeutic compounds containing cyclometallated ligand, and to test them in an in vitro model of hypoxic cancer. The presence of a carbon-metal bond is known to shift the light absorption properties of ruthenium polypyridyl complexes towards the photodynamic window, a wavelength range where light penetrates optimally into biological tissues. However, cyclometallation usually quenches the ligand photosubstitution properties of ruthenium compounds because it strongly modifies the energy of their excited states. In this project, I will introduce sterically hindering groups on the cyclometallated ligand to recover photoreactivity of the complexes while keeping light absorption at high wavelengths. The challenges of this project consist on the one hand in achieving efficient ligand photosubstitution reactions with cyclometallated ruthenium compounds, and on the other hand in minimizing the cytotoxicity in the dark while maximizing cytotoxicity after red light irradiation at low oxygen concentrations. The ruthenium prodrugs will be synthesized, their photochemical properties will be measured, and their cytotoxicity against human cancer cell lines will be determined in an in vitro model of hypoxic cancer. This project will set new grounds in the treatment of hypoxic tumours and propose a new way to overcome side effects occurring in traditional anticancer chemotherapy.

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The information about "CYLCORU4PACT" are provided by the European Opendata Portal: CORDIS opendata.

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