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Quantitative MRI of the brain using magnetic resonance fingerprinting

Total Cost €


EC-Contrib. €






 QuantMR7 project word cloud

Explore the words cloud of the QuantMR7 project. It provides you a very rough idea of what is the project "QuantMR7" about.

facilities    explored    5t    accelerated    outside    mrf    balanced    prompt    suffered    parametric    tissue    dimensional    t1    disease    stage    psychiatric    reconstruction    unexplored    mri    shown    optimized    image    exploited    magnetic    quantitative    sequence    patient    3d    relaxation    graphics    previously    group    mr    patients    healthy    maps    acquired    quantification    steady    monitoring    datasets    intrinsic    acquisition    transverse    implicated    estimation    insensitive    signs    strategies    data    multiple    pediatric    sensitivity    attempts    initial    interaction    accuracy    time    clinically    physical    clinical    compare    7t    brain    groups    sensitive    once    perform    featuring    technique    units    longitudinal    algorithm    susceptibility    imaging    t2    promise    precession    genetic    measured    fingerprinting    relatively    close    single    trajectories    noted    marker    protocols    resonance    differences    statistical    volunteer    bssfp    treatment    imperfections    software    slow    times    acceptable    alterations    contrasts    efficacy    free    neurological    strategy    infeasible    date   

Project "QuantMR7" data sheet

The following table provides information about the project.


Organization address
address: VIALE DEL TIRRENO 331
postcode: 56128
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 180˙277 €
 EC max contribution 180˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2018-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Alterations in the intrinsic physical tissue parameters measured with magnetic resonance imaging (MRI), such as of longitudinal (T1) and transverse (T2) relaxation times, have been implicated in major neurological conditions. Although these differences have been noted as useful signs in image contrasts, parameter quantification has not been exploited as a marker for disease stage or for monitoring treatment efficacy.

Previous attempts to perform quantitative MRI protocols have suffered from sensitivity to system imperfections as well as infeasible, long acquisition times. Recently, a new approach called MR fingerprinting (MRF) has been developed for the estimation of multiple parameters at once, featuring a new dedicated acquisition strategy. The method has shown great promise as data can be acquired in clinically acceptable time, is relatively insensitive to system imperfections and has high accuracy. To date, only two dimensional datasets using a single acquisition strategy (balanced steady state free precession bSSFP) have been explored. Further, this was using a rather slow reconstruction algorithm at 1.5T. In addition, the technique has not been yet applied outside healthy volunteer groups.

In this project we aim to develop a 3D MRF acquisition for imaging the whole brain with optimized acquisition trajectories. We will compare different acquisition strategies, including strategies sensitive to magnetic susceptibility in the brain, previously unexplored. The sequence parameters will be optimized using a dedicated novel genetic algorithm. An accelerated reconstruction software using a novel algorithm will be developed using graphics processing units. Initial data will be acquired with new protocols at 7T and at 1.5T. Statistical parametric maps will be used to investigate group differences. The close interaction with clinical facilities will facilitate the prompt application to patient groups, including neurological, psychiatric and pediatric patients.


year authors and title journal last update
List of publications.
2019 Matteo Cencini, Michela Tosetti, Guido Buonincontri
An Aristotelian View on MR-Based Attenuation Correction (ARISTOMRAC): Combining the Four Elements
published pages: 491-497, ISSN: 2469-7311, DOI: 10.1109/trpms.2019.2903593
IEEE Transactions on Radiation and Plasma Medical Sciences 3/4 2019-09-09
2019 Guido Buonincontri, Laura Biagi, Alessandra Retico, Paolo Cecchi, Mirco Cosottini, Ferdia A. Gallagher, Pedro A. Gómez, Martin J. Graves, Mary A. McLean, Frank Riemer, Rolf F. Schulte, Michela Tosetti, Fulvio Zaccagna, Joshua D. Kaggie
Multi-site repeatability and reproducibility of MR fingerprinting of the healthy brain at 1.5 and 3.0 T
published pages: 362-372, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2019.03.047
NeuroImage 195 2019-09-09
2019 Matteo Cencini, Laura Biagi, Joshua D. Kaggie, Rolf F. Schulte, Michela Tosetti, Guido Buonincontri
Magnetic resonance fingerprinting with dictionary-based fat and water separation (DBFW MRF): A multi-component approach
published pages: 3032-3045, ISSN: 0740-3194, DOI: 10.1002/mrm.27628
Magnetic Resonance in Medicine 81/5 2019-09-09
2018 Rolf F. Schulte, Guido Buonincontri, Mauro Costagli, Anne Menini, Florian Wiesinger, Ana Beatriz Solana
Silent T 2 * and T 2 encoding using ZTE combined with BURST
published pages: 2277-2287, ISSN: 0740-3194, DOI: 10.1002/mrm.27552
Magnetic Resonance in Medicine 81/4 2019-09-09
2019 Pedro A. Gómez, Miguel Molina-Romero, Guido Buonincontri, Marion I. Menzel, Bjoern H. Menze
Designing contrasts for rapid, simultaneous parameter quantification and flow visualization with quantitative transient-state imaging
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-44832-w
Scientific Reports 9/1 2019-09-09

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