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Quantitative MRI of the brain using magnetic resonance fingerprinting

Total Cost €


EC-Contrib. €






 QuantMR7 project word cloud

Explore the words cloud of the QuantMR7 project. It provides you a very rough idea of what is the project "QuantMR7" about.

exploited    relaxation    t1    outside    accelerated    marker    mri    precession    slow    mr    optimized    acceptable    times    close    unexplored    attempts    data    acquired    image    statistical    clinically    suffered    tissue    longitudinal    estimation    technique    efficacy    stage    multiple    protocols    balanced    facilities    monitoring    once    accuracy    imperfections    units    brain    alterations    dimensional    intrinsic    implicated    3d    strategy    patient    imaging    infeasible    resonance    physical    algorithm    steady    reconstruction    prompt    disease    psychiatric    mrf    compare    group    groups    perform    transverse    t2    volunteer    graphics    pediatric    quantification    sequence    time    magnetic    7t    patients    genetic    date    datasets    promise    sensitivity    software    sensitive    neurological    bssfp    single    healthy    contrasts    fingerprinting    acquisition    signs    insensitive    measured    explored    parametric    featuring    noted    differences    clinical    trajectories    treatment    maps    relatively    susceptibility    interaction    shown    free    5t    initial    strategies    previously    quantitative   

Project "QuantMR7" data sheet

The following table provides information about the project.


Organization address
address: VIALE DEL TIRRENO 331
postcode: 56128
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 180˙277 €
 EC max contribution 180˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-01   to  2018-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Alterations in the intrinsic physical tissue parameters measured with magnetic resonance imaging (MRI), such as of longitudinal (T1) and transverse (T2) relaxation times, have been implicated in major neurological conditions. Although these differences have been noted as useful signs in image contrasts, parameter quantification has not been exploited as a marker for disease stage or for monitoring treatment efficacy.

Previous attempts to perform quantitative MRI protocols have suffered from sensitivity to system imperfections as well as infeasible, long acquisition times. Recently, a new approach called MR fingerprinting (MRF) has been developed for the estimation of multiple parameters at once, featuring a new dedicated acquisition strategy. The method has shown great promise as data can be acquired in clinically acceptable time, is relatively insensitive to system imperfections and has high accuracy. To date, only two dimensional datasets using a single acquisition strategy (balanced steady state free precession bSSFP) have been explored. Further, this was using a rather slow reconstruction algorithm at 1.5T. In addition, the technique has not been yet applied outside healthy volunteer groups.

In this project we aim to develop a 3D MRF acquisition for imaging the whole brain with optimized acquisition trajectories. We will compare different acquisition strategies, including strategies sensitive to magnetic susceptibility in the brain, previously unexplored. The sequence parameters will be optimized using a dedicated novel genetic algorithm. An accelerated reconstruction software using a novel algorithm will be developed using graphics processing units. Initial data will be acquired with new protocols at 7T and at 1.5T. Statistical parametric maps will be used to investigate group differences. The close interaction with clinical facilities will facilitate the prompt application to patient groups, including neurological, psychiatric and pediatric patients.


year authors and title journal last update
List of publications.
2019 Matteo Cencini, Michela Tosetti, Guido Buonincontri
An Aristotelian View on MR-Based Attenuation Correction (ARISTOMRAC): Combining the Four Elements
published pages: 491-497, ISSN: 2469-7311, DOI: 10.1109/trpms.2019.2903593
IEEE Transactions on Radiation and Plasma Medical Sciences 3/4 2019-09-09
2019 Guido Buonincontri, Laura Biagi, Alessandra Retico, Paolo Cecchi, Mirco Cosottini, Ferdia A. Gallagher, Pedro A. Gómez, Martin J. Graves, Mary A. McLean, Frank Riemer, Rolf F. Schulte, Michela Tosetti, Fulvio Zaccagna, Joshua D. Kaggie
Multi-site repeatability and reproducibility of MR fingerprinting of the healthy brain at 1.5 and 3.0 T
published pages: 362-372, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2019.03.047
NeuroImage 195 2019-09-09
2019 Matteo Cencini, Laura Biagi, Joshua D. Kaggie, Rolf F. Schulte, Michela Tosetti, Guido Buonincontri
Magnetic resonance fingerprinting with dictionary-based fat and water separation (DBFW MRF): A multi-component approach
published pages: 3032-3045, ISSN: 0740-3194, DOI: 10.1002/mrm.27628
Magnetic Resonance in Medicine 81/5 2019-09-09
2018 Rolf F. Schulte, Guido Buonincontri, Mauro Costagli, Anne Menini, Florian Wiesinger, Ana Beatriz Solana
Silent T 2 * and T 2 encoding using ZTE combined with BURST
published pages: 2277-2287, ISSN: 0740-3194, DOI: 10.1002/mrm.27552
Magnetic Resonance in Medicine 81/4 2019-09-09
2019 Pedro A. Gómez, Miguel Molina-Romero, Guido Buonincontri, Marion I. Menzel, Bjoern H. Menze
Designing contrasts for rapid, simultaneous parameter quantification and flow visualization with quantitative transient-state imaging
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-44832-w
Scientific Reports 9/1 2019-09-09

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