Opendata, web and dolomites

EffectorTargets SIGNED

Development of functional genomic screens to identify conserved host cell processes targeted by fungal effector proteins

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 EffectorTargets project word cloud

Explore the words cloud of the EffectorTargets project. It provides you a very rough idea of what is the project "EffectorTargets" about.

effector    500    reaction    sp    vertebrates    interesting    fungal    plants    infects    function    proven    unravelling    yeast    found    reinhardtii    proteins    grow    medical    predicted    chlamydomonas    immunity    first    fungi    graminis    nutrients    plant    immune    bacterial    besides    though    defence    hosts    infect    nature    functions    reproduce    separately    supplies    act    rewire    plethora    reactions    majority    successful    turn    model    live    arms    encode    conserved    ways    host    contact    source    cerevisiae    cellular    express    time    date    humans    insects    opens    elucidate    eukaryotic    secreted    infection    parasite    roles    unknown    cells    insights    close    combat    saccharomyces    suppress    powdery    purposes    algae    circumvent    organisms    biotechnology    uses    successfully    effectors    race    hordei    pathogenicity    mounts    mildew    vast    pathogenic    barley    fungus    blumeria   

Project "EffectorTargets" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-09-09   to  2017-09-08

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 183˙454.00

Map

 Project objective

In nature, fungi live in close contact with many different hosts: plants, other fungi, insects and even vertebrates including humans. They do so because the host often supplies key nutrients, which enables the fungus to grow and successfully reproduce. In many cases though, a fungus can act as a parasite and infects the host. As a result, the host mounts an immune reaction to combat the fungal infection. The fungus, in turn, has evolved ways to circumvent the immune reaction. This “arms race” between fungus and host has given rise to a plethora of secreted proteins that the fungus uses to suppress the host immune responses and circumvent host defence reactions. These secreted proteins from fungi that function in this arms race are commonly known as “effectors”. A very important plant pathogenic fungus that is predicted to encode close to 500 of such effector proteins is the barley powdery mildew fungus Blumeria graminis f. sp. hordei. Unravelling the functions of these effector proteins will provide important insights into fungal pathogenicity and host immunity. To date, the roles of the vast majority of the effector proteins are unknown. One way to elucidate the functions of these numerous effector proteins is to express each separately in model eukaryotic organisms like yeast, Saccharomyces cerevisiae, or algae, Chlamydomonas reinhardtii and identify conserved cellular targets of these effector proteins. This approach has proven to be very successful in identifying targets of bacterial effector proteins. In the project described here, this yeast- and algae-based system will be applied for the first time for fungal effector proteins. Effectors are, besides being used by fungi to infect plants and other organisms, also a potential new source to rewire cells. When interesting conserved targets of these effectors are found, it opens up ways to use them in biotechnology and for medical purposes.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "EFFECTORTARGETS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "EFFECTORTARGETS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More  

VINCI (2020)

The Value of Information and Choice to Improve Control.

Read More  

AsymmFlow (2020)

Go with the continuous flow: Asymmetric Synthesis of Bioactive Alkaloids by Multistep Continuous-Flow Processes

Read More