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EffectorTargets SIGNED

Development of functional genomic screens to identify conserved host cell processes targeted by fungal effector proteins

Total Cost €

0

EC-Contrib. €

0

Partnership

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 EffectorTargets project word cloud

Explore the words cloud of the EffectorTargets project. It provides you a very rough idea of what is the project "EffectorTargets" about.

fungus    supplies    biotechnology    grow    successful    organisms    humans    secreted    successfully    algae    act    yeast    roles    saccharomyces    chlamydomonas    plethora    defence    live    predicted    host    purposes    first    graminis    function    express    medical    contact    blumeria    besides    500    suppress    cerevisiae    model    reaction    insights    interesting    opens    powdery    rewire    source    effector    pathogenic    found    combat    reinhardtii    effectors    sp    infect    fungi    hordei    infection    vast    circumvent    uses    proven    functions    proteins    arms    though    hosts    ways    encode    plants    close    parasite    conserved    reproduce    nutrients    immunity    eukaryotic    vertebrates    majority    fungal    reactions    nature    immune    race    unravelling    date    cells    time    mildew    cellular    elucidate    bacterial    infects    pathogenicity    barley    turn    unknown    plant    insects    mounts    separately   

Project "EffectorTargets" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-09-09   to  2017-09-08

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 183˙454.00

Map

 Project objective

In nature, fungi live in close contact with many different hosts: plants, other fungi, insects and even vertebrates including humans. They do so because the host often supplies key nutrients, which enables the fungus to grow and successfully reproduce. In many cases though, a fungus can act as a parasite and infects the host. As a result, the host mounts an immune reaction to combat the fungal infection. The fungus, in turn, has evolved ways to circumvent the immune reaction. This “arms race” between fungus and host has given rise to a plethora of secreted proteins that the fungus uses to suppress the host immune responses and circumvent host defence reactions. These secreted proteins from fungi that function in this arms race are commonly known as “effectors”. A very important plant pathogenic fungus that is predicted to encode close to 500 of such effector proteins is the barley powdery mildew fungus Blumeria graminis f. sp. hordei. Unravelling the functions of these effector proteins will provide important insights into fungal pathogenicity and host immunity. To date, the roles of the vast majority of the effector proteins are unknown. One way to elucidate the functions of these numerous effector proteins is to express each separately in model eukaryotic organisms like yeast, Saccharomyces cerevisiae, or algae, Chlamydomonas reinhardtii and identify conserved cellular targets of these effector proteins. This approach has proven to be very successful in identifying targets of bacterial effector proteins. In the project described here, this yeast- and algae-based system will be applied for the first time for fungal effector proteins. Effectors are, besides being used by fungi to infect plants and other organisms, also a potential new source to rewire cells. When interesting conserved targets of these effectors are found, it opens up ways to use them in biotechnology and for medical purposes.

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