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EffectorTargets SIGNED

Development of functional genomic screens to identify conserved host cell processes targeted by fungal effector proteins

Total Cost €

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EC-Contrib. €

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Partnership

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 EffectorTargets project word cloud

Explore the words cloud of the EffectorTargets project. It provides you a very rough idea of what is the project "EffectorTargets" about.

contact    insects    plants    500    biotechnology    immunity    unknown    graminis    plant    roles    reactions    saccharomyces    successfully    first    grow    algae    defence    nature    mildew    secreted    supplies    insights    pathogenic    organisms    effectors    act    barley    nutrients    infection    powdery    uses    time    suppress    parasite    cells    functions    express    mounts    pathogenicity    reinhardtii    rewire    separately    interesting    fungus    proteins    cerevisiae    medical    race    purposes    hosts    vast    reproduce    yeast    though    found    proven    ways    elucidate    opens    majority    date    unravelling    circumvent    function    source    infects    sp    fungi    infect    besides    plethora    humans    model    bacterial    immune    predicted    host    encode    turn    effector    eukaryotic    cellular    reaction    hordei    fungal    successful    live    combat    vertebrates    close    chlamydomonas    conserved    blumeria    arms   

Project "EffectorTargets" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-09-09   to  2017-09-08

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 183˙454.00

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 Project objective

In nature, fungi live in close contact with many different hosts: plants, other fungi, insects and even vertebrates including humans. They do so because the host often supplies key nutrients, which enables the fungus to grow and successfully reproduce. In many cases though, a fungus can act as a parasite and infects the host. As a result, the host mounts an immune reaction to combat the fungal infection. The fungus, in turn, has evolved ways to circumvent the immune reaction. This “arms race” between fungus and host has given rise to a plethora of secreted proteins that the fungus uses to suppress the host immune responses and circumvent host defence reactions. These secreted proteins from fungi that function in this arms race are commonly known as “effectors”. A very important plant pathogenic fungus that is predicted to encode close to 500 of such effector proteins is the barley powdery mildew fungus Blumeria graminis f. sp. hordei. Unravelling the functions of these effector proteins will provide important insights into fungal pathogenicity and host immunity. To date, the roles of the vast majority of the effector proteins are unknown. One way to elucidate the functions of these numerous effector proteins is to express each separately in model eukaryotic organisms like yeast, Saccharomyces cerevisiae, or algae, Chlamydomonas reinhardtii and identify conserved cellular targets of these effector proteins. This approach has proven to be very successful in identifying targets of bacterial effector proteins. In the project described here, this yeast- and algae-based system will be applied for the first time for fungal effector proteins. Effectors are, besides being used by fungi to infect plants and other organisms, also a potential new source to rewire cells. When interesting conserved targets of these effectors are found, it opens up ways to use them in biotechnology and for medical purposes.

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