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RESCBONE

The influence of mechanical loading on the decline in bone mass with ageing

Total Cost €

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EC-Contrib. €

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Partnership

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Project "RESCBONE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2017-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 195˙454.00

Map

 Project objective

Osteoporosis is an age and gender-related condition characterised by reduced bone mass, impaired micro-architecture and increased risk of low-trauma fractures. Osteoporosis-related fractures are a major health concern and impose a huge economic burden on European health care systems. In the young, bone adapts its mass and architecture in response to strains engendered by mechanical loading. However, this response in blunted in the aged. We have shown that the anabolic response to load is similarly impaired in an age and gender-related manner in mice. Counter-intuitively, this response can be “rescued” in aged female mice if short periods of loading are imposed against a background of disuse rather than activity. We hypothesise that this “rescue” involves increased recruitment of bone forming osteoblasts.

The primary objective of this proposal is, to establish whether the age and gender-related decline in bone’s adaptive response to mechanical loading in mice can be attributed to insufficient recruitment of osteoblasts necessary to form new bone and, if so, whether this deficiency can be “rescued” by appropriate manipulation of bones’ loading environment.

To achieve the objectives in this proposal, we will investigate bones from aged male and female mice, which have been subjected to mechanical loading with or without prior disuse. These will be compared with similarly treated bones of young mice. Our studies should further elucidate the mechanisms underlying the age-related decline in bones’ adaptive response to mechanical loading. We hope that these studies could identify novel therapeutic targets to augment bones’ natural anabolic response to physical activity/loading. This could be of particular relevance in maintaining bone mass in situations of aging, paralysis or even space flight. The proposal will strengthen the CV of the applicant and further collaboration between European laboratories.

 Publications

year authors and title journal last update
List of publications.
2015 Henry Todd, Gabriel L. Galea, Lee B. Meakin, Peter J. Delisser, Lance E. Lanyon, Sara H. Windahl, Joanna S. Price
Wnt16 Is Associated with Age-Related Bone Loss and Estrogen Withdrawal in Murine Bone
published pages: e0140260, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0140260
PLOS ONE 10/10 2019-07-23

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