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HoloVision TERMINATED

Advanced holographic optical neural stimulation for vision restoration and basic research

Total Cost €

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EC-Contrib. €

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Partnership

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 HoloVision project word cloud

Explore the words cloud of the HoloVision project. It provides you a very rough idea of what is the project "HoloVision" about.

retinal    nerve    photon    when    precise    ultimate    performance    surviving    spread    input    basic    cellular    light    multiphoton    holographic    currents    individuals    questions    transduced    ganglion    limited    translation    compromised    extend    cell    contact    artificial    human    offers    disrupted    scientific    optical    circuits    stimulation    tissue    optogenetic    natural    dynamically    micro    resolution    regular    substituting    resolve    combining    prototype    diseases    cortical    tackle    electrode    temporal    bypassing    clinical    series    sighted    populations    perception    interfaces    neural    sensory    neuro    invasive    cells    technologies    vision    implanted    ultimately    constraints    strategy    excitation    arrays    degenerative    induce    regarding    physical    neurons    requirement    efficacy    hons    translational    computer    single    outer    patterns    engineering    vivo    clinically    optogenetically    experiments    device    restoring    structured    normal    spatio    dimensional    nearly    sheep    photo    minimally    optimize    patterned    powerful    multiple    strategies    blind    electrical   

Project "HoloVision" data sheet

The following table provides information about the project.

Coordinator
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY 

Organization address
address: SENATE BUILDING TECHNION CITY
city: HAIFA
postcode: 32000
website: www.technion.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Project website https://niel.net.technion.ac.il/
 Total cost 2˙624˙517 €
 EC max contribution 2˙624˙517 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY IL (HAIFA) coordinator 2˙624˙517.00

Map

 Project objective

When natural sensory input is disrupted, as in outer-retinal degenerative diseases, artificial stimulation of surviving nerve cells offers a potential strategy for bypassing compromised neural circuits and substituting sensory perception. Current neuro-stimulation interfaces that use electrical currents from micro-electrode arrays are already being clinically applied for retinal stimulation, but their performance is ultimately limited by current spread and the requirement for physical contact with an implanted device. Future minimally-invasive systems could use light patterns to photo-induce complex yet precise spatio-temporal activity patterns among surviving retinal neurons, with the ultimate potential of restoring vision to a nearly normal level. Here, we will advance, optimize and test in vivo a powerful new strategy for cellular-resolution controlled patterned optogenetic excitation, based on computer-generated holographic optical neural-stimulation (HONS). Regular (one-photon) HONS systems can dynamically address large populations of optogenetically-transduced retinal ganglion cells with single-cell resolution, while related multiphoton HONS systems can extend these capabilities to three-dimensional cortical tissue (relevant to many research applications). A series of in vivo experiments will resolve basic questions regarding the efficacy of these approaches by directly examining the retinal and cortical responses to structured holographic photo-stimulation, and test novel strategies for improving it. Finally, as a major step towards clinical translation of this technology, we will design and evaluate (in blind sheep and sighted individuals) a human-scale prototype. Overall, by combining both basic and translational research, this study will advance novel optical neuro-technologies with potential impact on multiple scientific and clinical applications. Specifically, it will tackle the major engineering requirements and constraints towards the development of a

 Publications

year authors and title journal last update
List of publications.
2017 Ronald W. Boutte, Sam Merlin, Guy Yona, Brandon Griffiths, Alessandra Angelucci, Itamar Kahn, Shy Shoham, Steve Blair
Utah optrode array customization using stereotactic brain atlases and 3-D CAD modeling for optogenetic neocortical interrogation in small rodents and nonhuman primates
published pages: 41502, ISSN: 2329-423X, DOI: 10.1117/1.NPh.4.4.041502
Neurophotonics 4/4 2019-06-07
2018 Tal Aharoni, Shy Shoham
Phase-controlled, speckle-free holographic projection with applications in precision optogenetics
published pages: 1, ISSN: 2329-423X, DOI: 10.1117/1.NPh.5.2.025004
Neurophotonics 5/02 2019-06-07
2017 Anat Marom, Erez Shor, Shulamit Levenberg, Shy Shoham
Spontaneous Activity Characteristics of 3D “Optonets”
published pages: Article 602, ISSN: 1662-453X, DOI: 10.3389/fnins.2016.00602
Frontiers in Neuroscience 10 2019-06-07
2017 Michael Plaksin, Eitan Kimmel and Shy Shoham
Thermal transients excite neurons through universalintramembrane mechano-electrical effects
published pages: , ISSN: , DOI: 10.1101/111724
biorxiv 2019-06-07
2017 Michael Plaksin, Eitan Kimmel, Shy Shoham
Correspondence: Revisiting the theoretical cell membrane thermal capacitance response
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-00435-5
Nature Communications 8/1 2019-06-07

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The information about "HOLOVISION" are provided by the European Opendata Portal: CORDIS opendata.

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