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HoloVision TERMINATED

Advanced holographic optical neural stimulation for vision restoration and basic research

Total Cost €

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EC-Contrib. €

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Partnership

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 HoloVision project word cloud

Explore the words cloud of the HoloVision project. It provides you a very rough idea of what is the project "HoloVision" about.

patterns    input    outer    regular    offers    patterned    clinically    cells    vision    powerful    compromised    translation    micro    blind    circuits    dimensional    engineering    degenerative    contact    multiple    regarding    invasive    retinal    structured    questions    basic    efficacy    device    cell    nearly    single    optogenetic    excitation    tackle    individuals    substituting    ultimately    resolve    strategy    transduced    vivo    restoring    combining    strategies    neural    cortical    cellular    nerve    hons    constraints    normal    neurons    stimulation    surviving    extend    minimally    scientific    electrode    diseases    arrays    natural    multiphoton    bypassing    holographic    perception    sensory    optical    dynamically    sheep    ganglion    precise    when    clinical    physical    performance    light    temporal    requirement    neuro    series    optimize    induce    resolution    spread    prototype    translational    interfaces    ultimate    disrupted    photon    sighted    photo    human    spatio    technologies    implanted    computer    experiments    populations    optogenetically    artificial    electrical    tissue    limited    currents   

Project "HoloVision" data sheet

The following table provides information about the project.

Coordinator
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY 

Organization address
address: SENATE BUILDING TECHNION CITY
city: HAIFA
postcode: 32000
website: www.technion.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Project website https://niel.net.technion.ac.il/
 Total cost 2˙624˙517 €
 EC max contribution 2˙624˙517 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY IL (HAIFA) coordinator 2˙624˙517.00

Map

 Project objective

When natural sensory input is disrupted, as in outer-retinal degenerative diseases, artificial stimulation of surviving nerve cells offers a potential strategy for bypassing compromised neural circuits and substituting sensory perception. Current neuro-stimulation interfaces that use electrical currents from micro-electrode arrays are already being clinically applied for retinal stimulation, but their performance is ultimately limited by current spread and the requirement for physical contact with an implanted device. Future minimally-invasive systems could use light patterns to photo-induce complex yet precise spatio-temporal activity patterns among surviving retinal neurons, with the ultimate potential of restoring vision to a nearly normal level. Here, we will advance, optimize and test in vivo a powerful new strategy for cellular-resolution controlled patterned optogenetic excitation, based on computer-generated holographic optical neural-stimulation (HONS). Regular (one-photon) HONS systems can dynamically address large populations of optogenetically-transduced retinal ganglion cells with single-cell resolution, while related multiphoton HONS systems can extend these capabilities to three-dimensional cortical tissue (relevant to many research applications). A series of in vivo experiments will resolve basic questions regarding the efficacy of these approaches by directly examining the retinal and cortical responses to structured holographic photo-stimulation, and test novel strategies for improving it. Finally, as a major step towards clinical translation of this technology, we will design and evaluate (in blind sheep and sighted individuals) a human-scale prototype. Overall, by combining both basic and translational research, this study will advance novel optical neuro-technologies with potential impact on multiple scientific and clinical applications. Specifically, it will tackle the major engineering requirements and constraints towards the development of a

 Publications

year authors and title journal last update
List of publications.
2017 Ronald W. Boutte, Sam Merlin, Guy Yona, Brandon Griffiths, Alessandra Angelucci, Itamar Kahn, Shy Shoham, Steve Blair
Utah optrode array customization using stereotactic brain atlases and 3-D CAD modeling for optogenetic neocortical interrogation in small rodents and nonhuman primates
published pages: 41502, ISSN: 2329-423X, DOI: 10.1117/1.NPh.4.4.041502
Neurophotonics 4/4 2019-06-07
2018 Tal Aharoni, Shy Shoham
Phase-controlled, speckle-free holographic projection with applications in precision optogenetics
published pages: 1, ISSN: 2329-423X, DOI: 10.1117/1.NPh.5.2.025004
Neurophotonics 5/02 2019-06-07
2017 Anat Marom, Erez Shor, Shulamit Levenberg, Shy Shoham
Spontaneous Activity Characteristics of 3D “Optonets”
published pages: Article 602, ISSN: 1662-453X, DOI: 10.3389/fnins.2016.00602
Frontiers in Neuroscience 10 2019-06-07
2017 Michael Plaksin, Eitan Kimmel and Shy Shoham
Thermal transients excite neurons through universalintramembrane mechano-electrical effects
published pages: , ISSN: , DOI: 10.1101/111724
biorxiv 2019-06-07
2017 Michael Plaksin, Eitan Kimmel, Shy Shoham
Correspondence: Revisiting the theoretical cell membrane thermal capacitance response
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-00435-5
Nature Communications 8/1 2019-06-07

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