Explore the words cloud of the ARENAVIRUS project. It provides you a very rough idea of what is the project "ARENAVIRUS" about.
The following table provides information about the project.
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
|Coordinator Country||United Kingdom [UK]|
|Total cost||183˙454 €|
|EC max contribution||183˙454 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2015-05-01 to 2017-04-30|
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|1||THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD||UK (OXFORD)||coordinator||183˙454.00|
Over the last decades, multiple arenaviruses have emerged as zoonotic human pathogens. They cross the species barrier from their natural rodent hosts to humans and cause severe human disease. A key determinant of viral zoonotic transmission is the ability to bind the receptor molecules displayed on the surface of the host cell. Despite the threat these viruses cause to public health, little is known of how they infect the host and how they are targeted by the immune response. Furthermore, the treatment and prevention options are currently extremely limited. Using techniques in structural biology, virology, immunology and cell biology, the proposed work aims at demonstrating the molecular mechanisms by which arenaviruses attach to human cells and are neutralized by the humoral immune response. First, crystallographic analysis of viral attachment glycoproteins alone and in complex with functional cellular receptors will be performed. Second, recombinantly derived viral glycoproteins will be used as immunogens for generation of specific monoclonal antibody libraries. The co-crystal structures of viral glycoproteins with cross-reactive, neutralizing antibodies, carefully selected using cell-based assays, will reveal the structural basis of antibody-mediated arenavirus neutralization. Therefore, by analogy to the development of antibody-based therapy against Ebola virus, the outlined multidisciplinary investigation will enable the rational design of antiviral reagents and vaccines. The cross-disciplinary expertise, training and infrastructure available in the host and partner organizations will allow the Researcher to establish herself as a highly-skilled expert in molecular and structural virology. As an independent, multifaceted scientist, she will be able to make a tangible contribution to the development of novel antiviral therapies, thus improving the public health and economy and adding to science base both in Europe and worldwide.
|year||authors and title||journal||last update|
Yuguang Zhao, Jingshan Ren, Karl Harlos, Daniel M. Jones, Antra Zeltina, Thomas A. Bowden, Sergi Padilla-Parra, Elizabeth E. Fry, David I. Stuart
Toremifene interacts with and destabilizes the Ebola virus glycoprotein
published pages: 169-172, ISSN: 0028-0836, DOI: 10.1038/nature18615
Antra Zeltina, Thomas A. Bowden, Benhur Lee
Emerging Paramyxoviruses: Receptor Tropism and Zoonotic Potential
published pages: e1005390, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1005390
|PLOS Pathogens 12/2||2019-07-24|
Antra Zeltina, Stefanie A. Krumm, Mehmet Sahin, Weston B. Struwe, Karl Harlos, Jack H. Nunberg, Max Crispin, Daniel D. Pinschewer, Katie J. Doores, Thomas A. Bowden
Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization
published pages: , ISSN: 0027-8424, DOI:
Max Crispin, Antra Zeltina, Nicole Zitzmann, Thomas A Bowden
Native functionality and therapeutic targeting of arenaviral glycoproteins
published pages: 70-75, ISSN: 1879-6257, DOI: 10.1016/j.coviro.2016.04.001
|Current Opinion in Virology 18||2019-07-24|
Sai Li, Ilona Rissanen, Antra Zeltina, Jussi Hepojoki, Jayna Raghwani, Karl Harlos, OliverÂ G. Pybus, JuhaÂ T. Huiskonen, ThomasÂ A. Bowden
A Molecular-Level Account of the Antigenic Hantaviral Surface
published pages: 959-967, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2016.03.082
|Cell Reports 15/5||2019-07-24|
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