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ARENAVIRUS

Molecular mechanisms of arenavirus cell entry and antibody-mediated neutralization

Total Cost €

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EC-Contrib. €

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Partnership

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 ARENAVIRUS project word cloud

Explore the words cloud of the ARENAVIRUS project. It provides you a very rough idea of what is the project "ARENAVIRUS" about.

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Project "ARENAVIRUS" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.strubi.ox.ac.uk/profile/antra-zeltina
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2017-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 183˙454.00

Map

 Project objective

Over the last decades, multiple arenaviruses have emerged as zoonotic human pathogens. They cross the species barrier from their natural rodent hosts to humans and cause severe human disease. A key determinant of viral zoonotic transmission is the ability to bind the receptor molecules displayed on the surface of the host cell. Despite the threat these viruses cause to public health, little is known of how they infect the host and how they are targeted by the immune response. Furthermore, the treatment and prevention options are currently extremely limited. Using techniques in structural biology, virology, immunology and cell biology, the proposed work aims at demonstrating the molecular mechanisms by which arenaviruses attach to human cells and are neutralized by the humoral immune response. First, crystallographic analysis of viral attachment glycoproteins alone and in complex with functional cellular receptors will be performed. Second, recombinantly derived viral glycoproteins will be used as immunogens for generation of specific monoclonal antibody libraries. The co-crystal structures of viral glycoproteins with cross-reactive, neutralizing antibodies, carefully selected using cell-based assays, will reveal the structural basis of antibody-mediated arenavirus neutralization. Therefore, by analogy to the development of antibody-based therapy against Ebola virus, the outlined multidisciplinary investigation will enable the rational design of antiviral reagents and vaccines. The cross-disciplinary expertise, training and infrastructure available in the host and partner organizations will allow the Researcher to establish herself as a highly-skilled expert in molecular and structural virology. As an independent, multifaceted scientist, she will be able to make a tangible contribution to the development of novel antiviral therapies, thus improving the public health and economy and adding to science base both in Europe and worldwide.

 Publications

year authors and title journal last update
List of publications.
2016 Yuguang Zhao, Jingshan Ren, Karl Harlos, Daniel M. Jones, Antra Zeltina, Thomas A. Bowden, Sergi Padilla-Parra, Elizabeth E. Fry, David I. Stuart
Toremifene interacts with and destabilizes the Ebola virus glycoprotein
published pages: 169-172, ISSN: 0028-0836, DOI: 10.1038/nature18615
Nature 535/7610 2019-07-24
2016 Antra Zeltina, Thomas A. Bowden, Benhur Lee
Emerging Paramyxoviruses: Receptor Tropism and Zoonotic Potential
published pages: e1005390, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1005390
PLOS Pathogens 12/2 2019-07-24
2017 Antra Zeltina, Stefanie A. Krumm, Mehmet Sahin, Weston B. Struwe, Karl Harlos, Jack H. Nunberg, Max Crispin, Daniel D. Pinschewer, Katie J. Doores, Thomas A. Bowden
Convergent immunological solutions to Argentine hemorrhagic fever virus neutralization
published pages: , ISSN: 0027-8424, DOI:
PNAS 2019-07-24
2016 Max Crispin, Antra Zeltina, Nicole Zitzmann, Thomas A Bowden
Native functionality and therapeutic targeting of arenaviral glycoproteins
published pages: 70-75, ISSN: 1879-6257, DOI: 10.1016/j.coviro.2016.04.001
Current Opinion in Virology 18 2019-07-24
2016 Sai Li, Ilona Rissanen, Antra Zeltina, Jussi Hepojoki, Jayna Raghwani, Karl Harlos, Oliver G. Pybus, Juha T. Huiskonen, Thomas A. Bowden
A Molecular-Level Account of the Antigenic Hantaviral Surface
published pages: 959-967, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2016.03.082
Cell Reports 15/5 2019-07-24

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