Opendata, web and dolomites

MUCDIFF

Competition between the enteric pathogen Clostridium difficile and the commensal members of the gut microbiota for mucosal sugars

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MUCDIFF project word cloud

Explore the words cloud of the MUCDIFF project. It provides you a very rough idea of what is the project "MUCDIFF" about.

intestinal    sources    severity    expansion    sialic    last    safe    fish    positive    rates    acid    bacterial    outcompete    antibiotic    spectrometry    gram    limited    combination    microbiota    gut    mechanisms    colonize    eradicate    human    anaerobic    orchestrate    cdi    pathogens    situ    combining    elucidate    catabolize    stable    strains    acetylglucosamine    disturbance    mass    infection    catabolism    nutrient    emerged    glcnac    isotope    hybridization    nanosims    normal    competition    treatments    recurrence    disease    secondary    members    ion    colonization    mortality    probiotic    resolution    mucosal    cure    alternative    outbreaks    bacterium    carbohydrates    therapies    identification    enteric    tract    relies    vivo    viewed    decade    difficile    prevents    suppresses    sip    identity    treatment    fluorescence    commensal    basis    standardized    colonic    sugars    organisms    conventional    mechanism    treat    probing    alone    refractory    clostridium   

Project "MUCDIFF" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT WIEN 

Organization address
address: UNIVERSITATSRING 1
city: WIEN
postcode: 1010
website: www.univie.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website http://www.microbial-ecology.net/research/competition-between-the-enteric-pathogen-clostridium-difficile-and-the-commensal-members-of-the-gut-microbiota-for-mucosal-sugars
 Total cost 166˙156 €
 EC max contribution 166˙156 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2017-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT WIEN AT (WIEN) coordinator 166˙156.00

Map

 Project objective

Clostridium difficile is a Gram-positive, anaerobic bacterium that relies on the disturbance of the normal gut microbiota to colonize the human intestinal tract and cause infection and disease. In the last decade new strains of C. difficile have emerged to cause outbreaks of increased disease severity and higher recurrence and mortality rates. C. difficile infection (CDI) is becoming refractory to the conventional antibiotic treatments and probiotic-based approaches are viewed as promising alternative therapies to effectively treat CDI. The development of such bacterial-based treatments requires the identification of the mechanisms by which the commensal members of the gut microbiota are able to eradicate C. difficile, as well as of the identity of the members of the gut microbiota that orchestrate those mechanisms. Since nutrient competition is an important mechanism by which the colonic microbiota suppresses the growth of many enteric pathogens, I focus here on competition for limited nutrient sources, such as the gut mucosal sugars N-acetylglucosamine (GlcNAc) and sialic acid, as a mechanism by which the members of the gut microbiota can eradicate C. difficile. I will investigate in detail the importance of GlcNAc catabolism, both alone and in combination with the catabolism of sialic acid, for C. difficile expansion in the gut. Furthermore, by combining stable isotope probing (SIP) and fluorescence in situ hybridization (FISH) with high resolution secondary ion mass spectrometry (NanoSIMS) I propose to identify commensal members of the gut microbiota that can efficiently catabolize these mucosal carbohydrates in vivo and to evaluate the ability of the identified organisms to outcompete C. difficile. Thus, this work will contribute to elucidate the mechanisms by which the gut microbiota prevents C. difficile colonization and to identify members of the gut microbiota that can be the basis for an effective, safe and standardized treatment to cure CDI.

 Publications

year authors and title journal last update
List of publications.
2017 Fátima C. Pereira, David Berry
Microbial nutrient niches in the gut
published pages: 1366-1378, ISSN: 1462-2912, DOI: 10.1111/1462-2920.13659
Environmental Microbiology 19/4 2019-07-24
2017 Ladurner, Angela; Zehl, Martin; Grienke, Ulrike; Hofstadler, Christoph; Faur, Nadina; Fátima C Pereira; Berry, David; Dirsch, Verena M.; Rollinger, Judith M.
Allspice and Clove As Source of Triterpene Acids Activating the G Protein-Coupled Bile Acid Receptor TGR5
published pages: , ISSN: 1663-9812, DOI: 10.3389/fphar.2017.00468
Frontiers in Pharmacology 1 2019-07-24

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MUCDIFF" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MUCDIFF" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

ICARUS (2020)

Information Content of locAlisation: fRom classical to qUantum Systems

Read More  

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More  

ReSOLeS (2019)

New Reconfigurable Spectrum Optical Fibre Laser Sources

Read More