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YIELDFACTOR

Using SP1 to control plastid development and yield in cereals

Total Cost €

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EC-Contrib. €

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Partnership

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 YIELDFACTOR project word cloud

Explore the words cloud of the YIELDFACTOR project. It provides you a very rough idea of what is the project "YIELDFACTOR" about.

modifying    proteins    grain    beneficial    interconversion    rice    correlated    leaf    cereal    expression    skills    generate    delayed    linked    amyloplast    recently    manipulating    26s    content    ups    senescence    staygreen    plant    brachypodium    traits    e3    manipulated    components    strength    de    arabidopsis    degradation    thoroughly    function    ubiquitin    found    translocon    weight    starch    transformants    cytosolic    sensitive    inefficient    2012    membrane    time    encoded    versatile    655    yield    levels    first    suggest    regulate    mutants    unpublished    ligase    model    combination    host    germination    agriculture    types    plants    plastids    regulates    delaying    outer    nucleus    proteasome    significantly    resistance    seed    toc    achieves    transgenic    importing    responsible    data    suggests    science    etiolation    cereals    null    stress    sativa    decreasing    chloroplast    multiple    discovery    shown    survival    plastid    phenotype    expertise    complementarity    oryza    rates    338    distachyon    differentiation    sp1    lab   

Project "YIELDFACTOR" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://users.ox.ac.uk/
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-03-07   to  2018-03-06

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 195˙454.00

Map

 Project objective

Recently, the host lab found that a novel ubiquitin E3 ligase, SP1, regulates the translocon of the outer chloroplast membrane (TOC), which is responsible for importing nucleus-encoded proteins into plastids. SP1 achieves this by promoting the degradation TOC components by the cytosolic 26S proteasome. This is the first time the ubiquitin proteasome system (UPS) has been shown to directly regulate plastid development and function. By increasing or decreasing SP1 levels in transgenic Arabidopsis plants, multiple effects of SP1 were observed; e.g., inefficient de-etiolation leading to low survival rates and delayed leaf senescence in sp1 null mutants (Science 2012, 338:655-9). Also, sp1 mutants are significantly more sensitive to stress (unpublished). These data suggest that SP1 is important for the differentiation and interconversion of different plastid types, and all of the effects are highly correlated with plant growth and yield. Thus, discovery of SP1 strongly suggests potential applications in agriculture, such as delaying leaf senescence to produce a staygreen phenotype, or controlling amyloplast development during grain development, by modifying SP1 expression. This project will investigate the function of SP1 in cereals, and assess the potential of SP1 for manipulating plastids to improve cereal yield. I will generate transgenic plants with manipulated SP1 expression in Brachypodium distachyon (a versatile cereal model) and Oryza sativa (rice). I will study the development of plastids in the transformants, and assess the transformants for beneficial effects on yield parameters, such as starch content, seed weight, germination, de-etiolation, leaf senescence and stress resistance. At the end, I will have thoroughly assessed the potential use of SP1 for manipulating cereal traits linked to yield. A major strength of the proposal is the complementarity of my expertise with that of the host. Our unique combination of skills will ensure success of the project.

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The information about "YIELDFACTOR" are provided by the European Opendata Portal: CORDIS opendata.

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