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NanoMATe

Nanoparticles for Molecular Imaging of Atherosclerosis: from Diagnosis to Treatment

Total Cost €

0

EC-Contrib. €

0

Partnership

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 NanoMATe project word cloud

Explore the words cloud of the NanoMATe project. It provides you a very rough idea of what is the project "NanoMATe" about.

complications    stroke    detected    nanoparticles    severe    sensitivity    primary    sensitive    countries    manifestations    small    emerged    optical    nps    death    biological    atheromas    progression    capability    blood    cardiovascular    decade    clinical    ways    onset    cellular    relatively    inflammatory    leads    imaging    markers    atherosclerotic    secondary    selective    anatomy    heart    probes    customise    particles    vessel    diagnosis    local    disease    last    sers    metallic    atheroma    atherosclerosis    multiplexing    weaknesses    offers    disrupt    modality    light    innovative    treatment    causes    superior    plaque    inflammation    source    narrowing    pathology    biomedicine    plaques    molecular    isn    visualization    advantages    immune    tool    shone    raman    indicate    recognise    consequently    technologies    organs    composition    vessels    surface    spectroscopy    caused    flow    degree    enhancement    participates    affordable    outcome    arteries    possess   

Project "NanoMATe" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF GLASGOW 

Organization address
address: UNIVERSITY AVENUE
city: GLASGOW
postcode: G12 8QQ
website: www.gla.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://nanomatescience.weebly.com/
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2017-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF GLASGOW UK (GLASGOW) coordinator 183˙454.00

Map

 Project objective

Atherosclerosis is a disease of the arteries. It leads to the formation of atherosclerotic plaques (atheromas), which may disrupt the blood flow to target organs, leading to heart disease and stroke - the most common causes of death in developed countries. Cardiovascular imaging has traditionally focused on the anatomy of the atherosclerotic plaque; however, the degree of vessel narrowing caused by the plaque isn’t the only characteristic that can determine the clinical outcome. Indeed, the cellular and molecular composition of the atheroma can indicate whether the plaque might cause complications. In particular the local immune-inflammatory response participates from the onset of the pathology through its progression, up to clinical manifestations. Consequently the development of innovative approaches for the molecular imaging of inflammation in atherosclerosis would be key to improve diagnosis and treatment. In the last decade molecular imaging has emerged as a novel tool for the visualization and measurement of biological processes in atheromas. Various imaging technologies have been developed; however, each approach presents severe weaknesses. Surface Enhancement Raman Spectroscopy (SERS) is developing as an effective molecular imaging optical modality in biomedicine because it offers many advantages over traditional technologies, including better sensitivity, and a superior multiplexing capability. Therefore, the primary aim of the present proposal is to develop innovative, highly-sensitive and selective but relatively affordable SERS-based system to measure inflammation in atherosclerotic vessels. I will use nanoparticles (NPs), small metallic particles, which possess the ability to recognise inflammatory markers, as imaging probes. When a light source is shone on these NPs, they can be detected by SERS. The secondary aim is to customise the NPs to enable local treatment of the pathology. The proposed approaches will offer new ways to manage atherosclerosis.

 Publications

year authors and title journal last update
List of publications.
2018 Pasquale Maffia
Why we should reward peer reviewers
published pages: e30-e31, ISSN: 0008-6363, DOI: 10.1093/cvr/cvy050
Cardiovascular Research 114/5 2019-07-24
2017 Pasquale Maffia, Giuseppe Cirino
Targeting inflammation to reduce cardiovascular disease risk
published pages: 3895-3897, ISSN: 0007-1188, DOI: 10.1111/bph.14039
British Journal of Pharmacology 174/22 2019-07-24
2017 Paul Welsh, Gianluca Grassia, Shani Botha, Naveed Sattar, Pasquale Maffia
Targeting inflammation to reduce cardiovascular disease risk: a realistic clinical prospect?
published pages: , ISSN: 0007-1188, DOI: 10.1111/bph.13818
British Journal of Pharmacology 2019-07-24
2017 Neil MacRitchie, Gianluca Grassia, Jonathan Noonan, Paul Garside, Duncan Graham, Pasquale Maffia
Molecular imaging of atherosclerosis: spotlight on Raman spectroscopy and surface-enhanced Raman scattering
published pages: heartjnl-2017-31, ISSN: 1355-6037, DOI: 10.1136/heartjnl-2017-311447
Heart 2019-07-24
2017 Changjun Yin, Sarajo Mohanta, Pasquale Maffia, Andreas J. R. Habenicht
Editorial: Tertiary Lymphoid Organs (TLOs): Powerhouses of Disease Immunity
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.00228
Frontiers in Immunology 8 2019-07-24
2016 Prasad Srikakulapu, Desheng Hu, Changjun Yin, Sarajo K. Mohanta, Sai Vineela Bontha, Li Peng, Michael Beer, Christian Weber, Coleen A. McNamara, Gianluca Grassia, Pasquale Maffia, Rudolf A. Manz, Andreas J.R. Habenicht
Artery Tertiary Lymphoid Organs Control Multilayered Territorialized Atherosclerosis B-Cell Responses in Aged ApoE −/− MiceHighlights
published pages: 1174-1185, ISSN: 1079-5642, DOI: 10.1161/ATVBAHA.115.306983
Arteriosclerosis, Thrombosis, and Vascular Biology 36/6 2019-07-24
2016 Catherine E. Hughes, Robert A. Benson, Marija Bedaj, Pasquale Maffia
Antigen-Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs
published pages: 481, ISSN: 1664-3224, DOI: 10.3389/fimmu.2016.00481
Frontiers in Immunology 7 2019-07-24

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