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VANGUARD

Versatile optomechANical GRaphene Device for bio-tissue engineering

Total Cost €

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EC-Contrib. €

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Partnership

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 VANGUARD project word cloud

Explore the words cloud of the VANGUARD project. It provides you a very rough idea of what is the project "VANGUARD" about.

cells    light    spatial    model    layer    hierarchical    human    dynamical    device    grafting    organ    natural    entire    scaffolds    fabricating    desired    functions    contact    techniques    profile    scalable    idea    initially    deform    flat    partly    time    substrate    vanguard    business    care    components    manner    force    rough    modulator    mechanical    plan    efficient    adhesion    porous    consuming    thanks    maxima    laser    made    organs    first    health    designing    emerged    pixelated    graphene    tissues    asperities    fabricate    building    realize    caused    flexibility    injury    fabrication    dynamically    successful    restoring    repair    microscopy    strength    surface    regeneration    commercialization    reconfigurable    hardware    tissue    surfaces    vivo    engineering    costly    atomic    extremely    special    material    consists    mimic    utilize    consisting    surgical    attachment    membrane    versatile    damage    software    prototype    deposited    expanding    fold    detected    feasibility    single    damaged    seeding    vitro    combination    local    onto    deformation    easily    scaffold    oxide    shapes    analogously    roughness    accounts    opto    biological   

Project "VANGUARD" data sheet

The following table provides information about the project.

Coordinator
CONSIGLIO NAZIONALE DELLE RICERCHE 

Organization address
address: PIAZZALE ALDO MORO 7
city: ROMA
postcode: 185
website: www.cnr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2016-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) coordinator 150˙000.00

Map

 Project objective

Tissue and organ failure, caused by injury or other type of damage, accounts for a large part of the health care costs in EU and U.S. Current surgical or grafting procedures are only partly successful in restoring the functions of the damaged tissues.Tissue Engineering has emerged as a rapidly expanding field for repair and regeneration of damaged tissue and organs.This involves the seeding and attachment of human cells onto a scaffold through in-vitro, or a combination of in-vitro and in-vivo. Existing scaffold fabrication techniques are time consuming and costly. We plan to take the first steps towards the commercialization of a novel system to fabricate tissue scaffolds made of Graphene Oxide (GO) in an extremely dynamical and efficient manner. The prototype consists of opto-mechanical and laser components that will be used to dynamically deform the initially flat surface consisting of a single layer of GO deposited over a porous membrane. Specifically, we will utilize a Spatial Light Modulator laser and a novel software application in order to realize a pixelated surface with the desired profile. The spatial deformation will be controlled and detected with the use of Atomic Force Microscopy. Special shapes of the asperities, i.e. local surface maxima of a rough surface, enhance adhesion over the entire surface when in contact with a biological material. Analogously to known natural surfaces with hierarchical roughness, we aim to mimic this kind of effects by using Graphene thanks to its high strength and flexibility. All in all, the goal of VANGuaRD is two-fold: (1) to establish the technical feasibility of our idea by designing and building a highly versatile prototype device that includes both hardware and software components for fabricating easily reconfigurable GO-based scaffolds using only a single substrate. (2) to establish the commercialization potential of such system by means of designing a viable and scalable business model.

 Publications

year authors and title journal last update
List of publications.
2016 Maria Chiara Braidotti, Silvia Gentilini, Claudio Conti
Gamow vectors explain the shock profile
published pages: 21963, ISSN: 1094-4087, DOI: 10.1364/OE.24.021963
Optics Express 24/19 2019-07-24
2016 Renato Fastampa, Mauro Missori, Maria Chiara Braidotti, Claudio Conti, Maria Aurora Vincenti, Rosa Maria Montereali
Temperature behavior of optical absorption bands in colored LiF crystals
published pages: 74-75, ISSN: 2211-3797, DOI: 10.1016/j.rinp.2016.01.013
Results in Physics 6 2019-07-24
2016 Massimiliano Papi, Valentina Palmieri, Francesca Bugli, Marco De Spirito, Maurizio Sanguinetti, Carlotta Ciancico, Maria Chiara Braidotti, Silvia Gentilini, Luca Angelani, Claudio Conti
Biomimetic antimicrobial cloak by graphene-oxide agar hydrogel
published pages: 12, ISSN: 2045-2322, DOI: 10.1038/s4159801600107
Scientific Reports 6 2019-07-24
2015 Silvia Gentilini, Maria Chiara Braidotti, Giulia Marcucci, Eugenio DelRe, Claudio Conti
Physical realization of the Glauber quantum oscillator
published pages: 15816, ISSN: 2045-2322, DOI: 10.1038/srep15816
Scientific Reports 5 2019-07-24
2016 Maria Chiara Braidotti, Silvia Gentilini, Adam Fleming, Michiel C. Samuels, Andrea Di Falco, Claudio Conti
Optothermal nonlinearity of silica aerogel
published pages: 41104, ISSN: 0003-6951, DOI: 10.1063/1.4959240
Applied Physics Letters 109/4 2019-07-24

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The information about "VANGUARD" are provided by the European Opendata Portal: CORDIS opendata.

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