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UTILIUM SIGNED

Unraveling The Immune Landscape In Uveal Melanoma

Total Cost €

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EC-Contrib. €

0

Partnership

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 UTILIUM project word cloud

Explore the words cloud of the UTILIUM project. It provides you a very rough idea of what is the project "UTILIUM" about.

cancer    profiles    antitumor    detrimental    despite    autologous    successes    skills    quantitative    clinic    responsive    edge    center    um    uveal    presentation    herlev    qualitative    group    optimal    oncologist    bioinformatics    denmark    lymphocytes    gene    strategies    immune    cellular    hospital    lab    accelerate    overcome    career    shared    expression    genomics    reveal    mechanisms    overview    infiltrating    multiple    types    successful    melanoma    cell    reactivity    tumor    resistant    position    therapy    chances    leadership    suppression    microenvironment    immunohistochemistry    expanding    rna    technologies    breakthrough    markers    medical    checkpoint    potentially    tumors    metastases    landscape    innovative    employ    prof    immunotherapeutic    subset    experiments    svane    clinical    pave    permanent    copenhagen    neoantigen    expansion    cutting    inhibitors    cutaneous    appear    origin    manner    model    laboratory    immunotherapy    sequencing    explore    translational    cells    complete    treatment    latest    fight    immunology    subsequently    functional    underlying    multispectral   

Project "UTILIUM" data sheet

The following table provides information about the project.

Coordinator
REGION HOVEDSTADEN 

Organization address
address: KONGENS VAENGE 2
city: HILLEROD
postcode: 3400
website: www.regionh.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    REGION HOVEDSTADEN DK (HILLEROD) coordinator 200˙194.00

Map

 Project objective

Cancer Immunotherapy is the latest breakthrough in the fight against cancer, especially with the successes of checkpoint inhibitors. However, numerous tumors appear non-responsive, including uveal melanoma (UM) despite its shared cellular origin with cutaneous melanoma. In this project, I propose to study the immune landscape of UM and explore strategies to overcome mechanisms detrimental to the antitumor immune response. I will employ highly innovative technologies from the fields of genomics, immunology and bioinformatics to explore the tumor microenvironment. Gene expression profiles of UM metastases and neoantigen presentation will be obtained by RNA sequencing. The functional expression of multiple immune markers will be analyzed by cutting-edge multispectral immunohistochemistry to determine immune cell subset presence in a qualitative and quantitative manner. The obtained knowledge will subsequently be used to test and improve reactivity of tumor-infiltrating lymphocytes in an autologous model. These experiments require optimal expansion of tumor-infiltrating T cells, which is highly developed at the laboratory of prof. Svane at the Center for Cancer Immune Therapy at the Herlev Hospital in Copenhagen, Denmark. I expect that this project will provide a more complete overview of the immune landscape of UM and reveal important mechanisms underlying immune suppression in UM. The findings of this project could pave the way to the clinical development of successful immunotherapeutic strategies for the treatment of UM and potentially other tumor types resistant to immune checkpoint inhibitors. Finally, this project will improve my laboratory and leadership skills, greatly improving my chances of achieving the next goal in my career: a permanent position as an Medical Oncologist with my own lab-based group in the expanding field of Cancer Immunotherapy to accelerate the application of translational research into the clinic.

 Publications

year authors and title journal last update
List of publications.
2019 Bol, Ellebaek, Hoejberg, Bagger, Larsen, Klausen, Køhler, Schmidt, Bastholt, Kiilgaard, Donia, Svane
Real-World Impact of Immune Checkpoint Inhibitors in Metastatic Uveal Melanoma
published pages: 1489, ISSN: 2072-6694, DOI: 10.3390/cancers11101489
Cancers 11/10 2019-10-30

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The information about "UTILIUM" are provided by the European Opendata Portal: CORDIS opendata.

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