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UTILIUM SIGNED

Unraveling The Immune Landscape In Uveal Melanoma

Total Cost €

0

EC-Contrib. €

0

Partnership

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 UTILIUM project word cloud

Explore the words cloud of the UTILIUM project. It provides you a very rough idea of what is the project "UTILIUM" about.

landscape    profiles    autologous    suppression    microenvironment    detrimental    expansion    cell    translational    employ    sequencing    successes    fight    lab    bioinformatics    treatment    immunohistochemistry    reactivity    leadership    innovative    medical    clinical    successful    functional    center    um    breakthrough    pave    metastases    uveal    cutting    neoantigen    optimal    infiltrating    overcome    subset    copenhagen    chances    explore    manner    resistant    technologies    antitumor    cutaneous    accelerate    edge    types    expression    origin    tumor    quantitative    prof    cells    group    herlev    multiple    genomics    inhibitors    checkpoint    experiments    tumors    responsive    complete    oncologist    laboratory    model    denmark    potentially    gene    svane    melanoma    immunology    subsequently    underlying    lymphocytes    reveal    permanent    multispectral    skills    qualitative    cellular    career    presentation    expanding    overview    hospital    appear    immune    clinic    strategies    markers    latest    immunotherapy    rna    therapy    cancer    despite    mechanisms    immunotherapeutic    position    shared   

Project "UTILIUM" data sheet

The following table provides information about the project.

Coordinator		 REGION HOVEDSTADEN 

Organization address
address: KONGENS VAENGE 2
city: HILLEROD
postcode: 3400
website: www.regionh.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Denmark [DK]
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    REGION HOVEDSTADEN DK (HILLEROD) coordinator 200˙194.00

Map

 Project objective

Cancer Immunotherapy is the latest breakthrough in the fight against cancer, especially with the successes of checkpoint inhibitors. However, numerous tumors appear non-responsive, including uveal melanoma (UM) despite its shared cellular origin with cutaneous melanoma. In this project, I propose to study the immune landscape of UM and explore strategies to overcome mechanisms detrimental to the antitumor immune response. I will employ highly innovative technologies from the fields of genomics, immunology and bioinformatics to explore the tumor microenvironment. Gene expression profiles of UM metastases and neoantigen presentation will be obtained by RNA sequencing. The functional expression of multiple immune markers will be analyzed by cutting-edge multispectral immunohistochemistry to determine immune cell subset presence in a qualitative and quantitative manner. The obtained knowledge will subsequently be used to test and improve reactivity of tumor-infiltrating lymphocytes in an autologous model. These experiments require optimal expansion of tumor-infiltrating T cells, which is highly developed at the laboratory of prof. Svane at the Center for Cancer Immune Therapy at the Herlev Hospital in Copenhagen, Denmark. I expect that this project will provide a more complete overview of the immune landscape of UM and reveal important mechanisms underlying immune suppression in UM. The findings of this project could pave the way to the clinical development of successful immunotherapeutic strategies for the treatment of UM and potentially other tumor types resistant to immune checkpoint inhibitors. Finally, this project will improve my laboratory and leadership skills, greatly improving my chances of achieving the next goal in my career: a permanent position as an Medical Oncologist with my own lab-based group in the expanding field of Cancer Immunotherapy to accelerate the application of translational research into the clinic.

 Publications

year authors and title journal last update
List of publications.
2019 Bol, Ellebaek, Hoejberg, Bagger, Larsen, Klausen, Køhler, Schmidt, Bastholt, Kiilgaard, Donia, Svane
Real-World Impact of Immune Checkpoint Inhibitors in Metastatic Uveal Melanoma
published pages: 1489, ISSN: 2072-6694, DOI: 10.3390/cancers11101489 		Cancers 11/10 2019-10-30

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The information about "UTILIUM" are provided by the European Opendata Portal: CORDIS opendata.

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