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UTILIUM SIGNED

Unraveling The Immune Landscape In Uveal Melanoma

Total Cost €

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EC-Contrib. €

0

Partnership

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 UTILIUM project word cloud

Explore the words cloud of the UTILIUM project. It provides you a very rough idea of what is the project "UTILIUM" about.

subset    accelerate    landscape    treatment    expanding    hospital    medical    immunotherapy    edge    pave    cellular    position    successful    rna    strategies    autologous    svane    immunology    manner    profiles    checkpoint    fight    despite    reactivity    metastases    underlying    immunohistochemistry    therapy    cancer    expression    tumor    suppression    prof    explore    responsive    permanent    immune    chances    reveal    experiments    skills    tumors    breakthrough    presentation    sequencing    copenhagen    model    inhibitors    immunotherapeutic    bioinformatics    genomics    complete    expansion    cutaneous    neoantigen    oncologist    laboratory    clinical    multispectral    optimal    cutting    overcome    qualitative    innovative    latest    multiple    technologies    resistant    markers    lab    translational    successes    subsequently    leadership    antitumor    overview    lymphocytes    functional    center    mechanisms    detrimental    clinic    employ    shared    microenvironment    uveal    types    melanoma    herlev    group    um    cells    origin    potentially    infiltrating    quantitative    appear    gene    career    cell    denmark   

Project "UTILIUM" data sheet

The following table provides information about the project.

Coordinator
REGION HOVEDSTADEN 

Organization address
address: KONGENS VAENGE 2
city: HILLEROD
postcode: 3400
website: www.regionh.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    REGION HOVEDSTADEN DK (HILLEROD) coordinator 200˙194.00

Map

 Project objective

Cancer Immunotherapy is the latest breakthrough in the fight against cancer, especially with the successes of checkpoint inhibitors. However, numerous tumors appear non-responsive, including uveal melanoma (UM) despite its shared cellular origin with cutaneous melanoma. In this project, I propose to study the immune landscape of UM and explore strategies to overcome mechanisms detrimental to the antitumor immune response. I will employ highly innovative technologies from the fields of genomics, immunology and bioinformatics to explore the tumor microenvironment. Gene expression profiles of UM metastases and neoantigen presentation will be obtained by RNA sequencing. The functional expression of multiple immune markers will be analyzed by cutting-edge multispectral immunohistochemistry to determine immune cell subset presence in a qualitative and quantitative manner. The obtained knowledge will subsequently be used to test and improve reactivity of tumor-infiltrating lymphocytes in an autologous model. These experiments require optimal expansion of tumor-infiltrating T cells, which is highly developed at the laboratory of prof. Svane at the Center for Cancer Immune Therapy at the Herlev Hospital in Copenhagen, Denmark. I expect that this project will provide a more complete overview of the immune landscape of UM and reveal important mechanisms underlying immune suppression in UM. The findings of this project could pave the way to the clinical development of successful immunotherapeutic strategies for the treatment of UM and potentially other tumor types resistant to immune checkpoint inhibitors. Finally, this project will improve my laboratory and leadership skills, greatly improving my chances of achieving the next goal in my career: a permanent position as an Medical Oncologist with my own lab-based group in the expanding field of Cancer Immunotherapy to accelerate the application of translational research into the clinic.

 Publications

year authors and title journal last update
List of publications.
2019 Bol, Ellebaek, Hoejberg, Bagger, Larsen, Klausen, Køhler, Schmidt, Bastholt, Kiilgaard, Donia, Svane
Real-World Impact of Immune Checkpoint Inhibitors in Metastatic Uveal Melanoma
published pages: 1489, ISSN: 2072-6694, DOI: 10.3390/cancers11101489
Cancers 11/10 2019-10-30

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The information about "UTILIUM" are provided by the European Opendata Portal: CORDIS opendata.

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