Opendata, web and dolomites
  1. home
  2. trasparenza
  3. open h2020
  4. utilium

UTILIUM SIGNED

Unraveling The Immune Landscape In Uveal Melanoma

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 UTILIUM project word cloud

Explore the words cloud of the UTILIUM project. It provides you a very rough idea of what is the project "UTILIUM" about.

landscape    multiple    sequencing    treatment    rna    cutaneous    technologies    detrimental    latest    copenhagen    profiles    innovative    employ    translational    lymphocytes    cutting    origin    cellular    optimal    breakthrough    antitumor    clinic    um    skills    permanent    immune    autologous    medical    denmark    successes    despite    expression    expanding    underlying    manner    melanoma    edge    immunotherapy    checkpoint    tumors    resistant    svane    potentially    position    herlev    tumor    functional    expansion    microenvironment    inhibitors    immunology    overview    cell    subset    immunohistochemistry    suppression    model    cancer    therapy    successful    center    infiltrating    reveal    markers    shared    explore    lab    responsive    chances    clinical    genomics    hospital    bioinformatics    prof    types    strategies    career    mechanisms    presentation    oncologist    pave    appear    gene    group    multispectral    uveal    cells    laboratory    leadership    overcome    subsequently    quantitative    accelerate    reactivity    experiments    immunotherapeutic    fight    metastases    complete    qualitative    neoantigen   

Project "UTILIUM" data sheet

The following table provides information about the project.

Coordinator		 REGION HOVEDSTADEN 

Organization address
address: KONGENS VAENGE 2
city: HILLEROD
postcode: 3400
website: www.regionh.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Denmark [DK]
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    REGION HOVEDSTADEN DK (HILLEROD) coordinator 200˙194.00

Map

 Project objective

Cancer Immunotherapy is the latest breakthrough in the fight against cancer, especially with the successes of checkpoint inhibitors. However, numerous tumors appear non-responsive, including uveal melanoma (UM) despite its shared cellular origin with cutaneous melanoma. In this project, I propose to study the immune landscape of UM and explore strategies to overcome mechanisms detrimental to the antitumor immune response. I will employ highly innovative technologies from the fields of genomics, immunology and bioinformatics to explore the tumor microenvironment. Gene expression profiles of UM metastases and neoantigen presentation will be obtained by RNA sequencing. The functional expression of multiple immune markers will be analyzed by cutting-edge multispectral immunohistochemistry to determine immune cell subset presence in a qualitative and quantitative manner. The obtained knowledge will subsequently be used to test and improve reactivity of tumor-infiltrating lymphocytes in an autologous model. These experiments require optimal expansion of tumor-infiltrating T cells, which is highly developed at the laboratory of prof. Svane at the Center for Cancer Immune Therapy at the Herlev Hospital in Copenhagen, Denmark. I expect that this project will provide a more complete overview of the immune landscape of UM and reveal important mechanisms underlying immune suppression in UM. The findings of this project could pave the way to the clinical development of successful immunotherapeutic strategies for the treatment of UM and potentially other tumor types resistant to immune checkpoint inhibitors. Finally, this project will improve my laboratory and leadership skills, greatly improving my chances of achieving the next goal in my career: a permanent position as an Medical Oncologist with my own lab-based group in the expanding field of Cancer Immunotherapy to accelerate the application of translational research into the clinic.

 Publications

year authors and title journal last update
List of publications.
2019 Bol, Ellebaek, Hoejberg, Bagger, Larsen, Klausen, Køhler, Schmidt, Bastholt, Kiilgaard, Donia, Svane
Real-World Impact of Immune Checkpoint Inhibitors in Metastatic Uveal Melanoma
published pages: 1489, ISSN: 2072-6694, DOI: 10.3390/cancers11101489 		Cancers 11/10 2019-10-30

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "UTILIUM" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "UTILIUM" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

LiverMacRegenCircuit (2020)

Elucidating the role of macrophages in liver regeneration and tissue unit formation

Read More  

MY MITOCOMPLEX (2021)

Functional relevance of mitochondrial supercomplex assembly in myeloid cells

Read More  

SAInTHz (2020)

Structuration of aqueous interfaces by Terahertz pulses: A study by Second Harmonic and Sum Frequency Generation

Read More