Opendata, web and dolomites

UTILIUM SIGNED

Unraveling The Immune Landscape In Uveal Melanoma

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 UTILIUM project word cloud

Explore the words cloud of the UTILIUM project. It provides you a very rough idea of what is the project "UTILIUM" about.

svane    suppression    optimal    successes    cellular    cell    antitumor    career    strategies    lab    multispectral    prof    um    employ    neoantigen    quantitative    model    cutting    profiles    laboratory    immunohistochemistry    lymphocytes    translational    microenvironment    center    fight    autologous    immunotherapy    innovative    manner    denmark    herlev    immune    underlying    responsive    bioinformatics    hospital    appear    treatment    multiple    potentially    pave    skills    mechanisms    chances    medical    explore    origin    uveal    types    cancer    clinic    cutaneous    detrimental    infiltrating    rna    reveal    resistant    breakthrough    tumors    gene    subsequently    subset    inhibitors    qualitative    markers    successful    metastases    oncologist    copenhagen    cells    checkpoint    accelerate    clinical    presentation    expansion    overcome    technologies    shared    tumor    immunotherapeutic    group    immunology    expression    functional    reactivity    genomics    landscape    edge    despite    sequencing    melanoma    therapy    latest    complete    permanent    leadership    overview    expanding    position    experiments   

Project "UTILIUM" data sheet

The following table provides information about the project.

Coordinator
REGION HOVEDSTADEN 

Organization address
address: KONGENS VAENGE 2
city: HILLEROD
postcode: 3400
website: www.regionh.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    REGION HOVEDSTADEN DK (HILLEROD) coordinator 200˙194.00

Map

 Project objective

Cancer Immunotherapy is the latest breakthrough in the fight against cancer, especially with the successes of checkpoint inhibitors. However, numerous tumors appear non-responsive, including uveal melanoma (UM) despite its shared cellular origin with cutaneous melanoma. In this project, I propose to study the immune landscape of UM and explore strategies to overcome mechanisms detrimental to the antitumor immune response. I will employ highly innovative technologies from the fields of genomics, immunology and bioinformatics to explore the tumor microenvironment. Gene expression profiles of UM metastases and neoantigen presentation will be obtained by RNA sequencing. The functional expression of multiple immune markers will be analyzed by cutting-edge multispectral immunohistochemistry to determine immune cell subset presence in a qualitative and quantitative manner. The obtained knowledge will subsequently be used to test and improve reactivity of tumor-infiltrating lymphocytes in an autologous model. These experiments require optimal expansion of tumor-infiltrating T cells, which is highly developed at the laboratory of prof. Svane at the Center for Cancer Immune Therapy at the Herlev Hospital in Copenhagen, Denmark. I expect that this project will provide a more complete overview of the immune landscape of UM and reveal important mechanisms underlying immune suppression in UM. The findings of this project could pave the way to the clinical development of successful immunotherapeutic strategies for the treatment of UM and potentially other tumor types resistant to immune checkpoint inhibitors. Finally, this project will improve my laboratory and leadership skills, greatly improving my chances of achieving the next goal in my career: a permanent position as an Medical Oncologist with my own lab-based group in the expanding field of Cancer Immunotherapy to accelerate the application of translational research into the clinic.

 Publications

year authors and title journal last update
List of publications.
2019 Bol, Ellebaek, Hoejberg, Bagger, Larsen, Klausen, Køhler, Schmidt, Bastholt, Kiilgaard, Donia, Svane
Real-World Impact of Immune Checkpoint Inhibitors in Metastatic Uveal Melanoma
published pages: 1489, ISSN: 2072-6694, DOI: 10.3390/cancers11101489
Cancers 11/10 2019-10-30

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "UTILIUM" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "UTILIUM" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

PFCmap (2020)

Development of neural circuits in the prefrontal cortex

Read More  

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More  

TheaTheor (2018)

Theorizing the Production of 'Comedia Nueva': The Process of Play Configuration in Spanish Golden Age Theater

Read More