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UTILIUM SIGNED

Unraveling The Immune Landscape In Uveal Melanoma

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 UTILIUM project word cloud

Explore the words cloud of the UTILIUM project. It provides you a very rough idea of what is the project "UTILIUM" about.

clinical    career    inhibitors    appear    metastases    reactivity    lymphocytes    origin    complete    skills    laboratory    despite    rna    checkpoint    breakthrough    overview    gene    successes    cutaneous    sequencing    cutting    suppression    cellular    immunohistochemistry    resistant    successful    detrimental    manner    cell    presentation    responsive    technologies    translational    landscape    markers    strategies    expression    quantitative    tumor    types    autologous    immune    group    leadership    multispectral    innovative    center    employ    um    cells    qualitative    underlying    cancer    permanent    neoantigen    clinic    expanding    immunology    genomics    pave    edge    reveal    shared    expansion    overcome    accelerate    functional    immunotherapeutic    prof    latest    microenvironment    subset    therapy    denmark    svane    tumors    position    lab    medical    subsequently    explore    optimal    hospital    multiple    melanoma    antitumor    mechanisms    experiments    model    fight    herlev    potentially    bioinformatics    infiltrating    profiles    uveal    chances    oncologist    copenhagen    treatment    immunotherapy   

Project "UTILIUM" data sheet

The following table provides information about the project.

Coordinator		 REGION HOVEDSTADEN 

Organization address
address: KONGENS VAENGE 2
city: HILLEROD
postcode: 3400
website: www.regionh.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Denmark [DK]
 Total cost 200˙194 €
 EC max contribution 200˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    REGION HOVEDSTADEN DK (HILLEROD) coordinator 200˙194.00

Map

 Project objective

Cancer Immunotherapy is the latest breakthrough in the fight against cancer, especially with the successes of checkpoint inhibitors. However, numerous tumors appear non-responsive, including uveal melanoma (UM) despite its shared cellular origin with cutaneous melanoma. In this project, I propose to study the immune landscape of UM and explore strategies to overcome mechanisms detrimental to the antitumor immune response. I will employ highly innovative technologies from the fields of genomics, immunology and bioinformatics to explore the tumor microenvironment. Gene expression profiles of UM metastases and neoantigen presentation will be obtained by RNA sequencing. The functional expression of multiple immune markers will be analyzed by cutting-edge multispectral immunohistochemistry to determine immune cell subset presence in a qualitative and quantitative manner. The obtained knowledge will subsequently be used to test and improve reactivity of tumor-infiltrating lymphocytes in an autologous model. These experiments require optimal expansion of tumor-infiltrating T cells, which is highly developed at the laboratory of prof. Svane at the Center for Cancer Immune Therapy at the Herlev Hospital in Copenhagen, Denmark. I expect that this project will provide a more complete overview of the immune landscape of UM and reveal important mechanisms underlying immune suppression in UM. The findings of this project could pave the way to the clinical development of successful immunotherapeutic strategies for the treatment of UM and potentially other tumor types resistant to immune checkpoint inhibitors. Finally, this project will improve my laboratory and leadership skills, greatly improving my chances of achieving the next goal in my career: a permanent position as an Medical Oncologist with my own lab-based group in the expanding field of Cancer Immunotherapy to accelerate the application of translational research into the clinic.

 Publications

year authors and title journal last update
List of publications.
2019 Bol, Ellebaek, Hoejberg, Bagger, Larsen, Klausen, Køhler, Schmidt, Bastholt, Kiilgaard, Donia, Svane
Real-World Impact of Immune Checkpoint Inhibitors in Metastatic Uveal Melanoma
published pages: 1489, ISSN: 2072-6694, DOI: 10.3390/cancers11101489 		Cancers 11/10 2019-10-30

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The information about "UTILIUM" are provided by the European Opendata Portal: CORDIS opendata.

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