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REACTION

Evaluation of the efficacy and of the antiviral activity of T-705 (favipiravir) duringEbola virus infection in non-human primates humans

Total Cost €

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EC-Contrib. €

0

Partnership

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 REACTION project word cloud

Explore the words cloud of the REACTION project. It provides you a very rough idea of what is the project "REACTION" about.

ebov    favipiravir    exceeded    expertise    evaluation    hence    experts    tested    replication    dimensions    commitment    effect    humanitarian    proven    extensively    shifted    toyoma    viruses    political    region    prevent    emergency    context    antiviral    drug    date    difficult    gathered    chemical    prevention    infected    rna    sept    2000    economic    september    inhibits    medicine    treatment    west    health    mitigate    deadliest    immensely    reaction    therapeutic    till    crisis    inhibit    patients    ebola    approved    pandemic    vitro    gene    ongoing    severe    world    treat    safety    excellent    spread    security    upscale    reported    public    curative    outbreaks    experimental    total    therapies    sociocultural    profile    fujifilm    africa    influenza    vaccines    interventions    flue    stock    containing    vaccine    2014    option    candidates    epidemic    humans    vivo    japan    cells    social    outbreak    viral    propagation    adverse    shown    producer    consultation   

Project "REACTION" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://www.reaction-ebola.eu/
 Total cost 2˙755˙719 €
 EC max contribution 2˙575˙809 € (93%)
 Programme 1. H2020-EU.3.1. (SOCIETAL CHALLENGES - Health, demographic change and well-being)
 Code Call H2020-Adhoc-2014-20
 Funding Scheme RIA
 Starting year 2014
 Duration (year-month-day) from 2014-11-01   to  2017-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙240˙726.00
2    ASSOCIATION POUR LE DEVELOPPEMENT DE L'ENSEIGNEMENT ET DES RECHERCHES AUPRES DES UNIVERSITES, DES CENTRES DE RECHERCHE ET DES ENTREPRISES D'AQUITAINE FR (PESSAC) participant 477˙262.00
3    ECOLE NORMALE SUPERIEURE DE LYON FR (LYON) participant 142˙500.00
4    UNIVERSITE CHEIKH ANTA DIOP DE DAKAR SN (DAKAR FANN) participant 134˙375.00
5    DRUG DISCOVERY FACTORY BV NL (AMSTERDAM DUIVENRECHT) participant 127˙062.00
6    UNIVERSITE D'AIX MARSEILLE FR (Marseille) participant 88˙500.00
7    RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG DE (HEIDELBERG) participant 86˙250.00
8    INSTITUT PASTEUR FR (PARIS CEDEX 15) participant 74˙025.00
9    UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) participant 72˙359.00
10    BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN DE (HAMBURG) participant 64˙250.00
11    Department of Health UK (Leeds) participant 64˙250.00
12    UNIVERSITEIT UTRECHT NL (UTRECHT) participant 4˙250.00
13    FONDATION POUR L INSTITUT DE HAUTES ETUDES INTERNATIONALES ET DU DEVELOPPEMENT CH (GENEVE) participant 0.00

Map

 Project objective

The ongoing Ebola outbreak in West Africa is the largest and deadliest the world has ever seen. In September 2014, the number of EBOV cases exceeded the total of all cases from previous known outbreaks. Further, this public health crisis shifted into a complex emergency, with significant, social, economic, humanitarian, political and security dimensions. Till date, no effective medicine has been proven to be effective against EBOV. As a result, it is immensely difficult to mitigate the current outbreak as well as prevent further outbreaks in this region. On Sept 4-5 2014, the WHO gathered expertise on experimental therapies and vaccines and their role in containing the Ebola outbreak in West Africa. During this consultation, experts identified several therapeutic and vaccine interventions that should be the focus of priority evaluation. Among these candidates is the existing antiviral drug Favipiravir, that has proven activity against many RNA viruses in vivo and in vitro including Ebola. Favipiravir is known to inhibit viral gene replication within infected cells to prevent propagation among which it inhibits viral gene replication within infected cells to prevent propagation. Hence, Favipiravir is currently aimed as a curative option in severe pandemic flue. Furthermore, there is currently enough stock of Favipiravir to even treat more than 20.000 patients, and the producer of Favipiravir, Toyoma Chemical/Fujifilm in Japan is willing to rapidly upscale the production of this drug. This drug has been extensively tested in humans and approved in Japan for treatment and prevention of influenza. The drug has shown an excellent safety profile in more than 2000 patients tested and no major adverse effect were reported. The current crisis requires both an immediate response to treat patients and prevent the further spread of the epidemic, as well as long term commitment in the complex sociocultural context. REACTION! will address both needs.

 Deliverables

List of deliverables.
All approvals package Documents, reports 2019-05-30 12:44:45
Software prediction Favipiravir treatment Other 2019-05-30 12:44:47
Intervention draft Demonstrators, pilots, prototypes 2019-05-30 12:44:49
report effect Favipiravir in mice Documents, reports 2019-05-30 12:44:27
Active dissemination Documents, reports 2019-05-30 12:44:45
Report 2 educational activities and surveys REACTION! Documents, reports 2019-05-30 12:44:42
Report on the antiviral efficacy of Favipiravir in humans Documents, reports 2019-05-30 12:44:38
Manuscript 1 Documents, reports 2019-05-30 12:44:48
Publication scientific papers Documents, reports 2019-05-30 12:44:45
Report modviro-immunological markers in NHPs Documents, reports 2019-05-30 12:44:29
Special issue Documents, reports 2019-05-30 12:44:26
scientific documents on website plus discussion forum launch Documents, reports 2019-05-30 12:44:42
Manual and toolkit Documents, reports 2019-05-30 12:44:48
Report on Symposium Documents, reports 2019-05-30 12:44:48
Manuscript 2 Documents, reports 2019-05-30 12:44:47
publication 2 Documents, reports 2019-05-30 12:44:27
publication 1 Documents, reports 2019-05-30 12:44:29
Report 1 educational activities and surveys REACTION! Documents, reports 2019-05-30 12:44:42

Take a look to the deliverables list in detail:  detailed list of REACTION deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 Nathan Peiffer-Smadja, Ramatou Ouedraogo, Eric D\'Ortenzio, Papa Ndiaga Cissé, Zahra Zeggani, Abdoul Habib Beavogui, Sylvain Landry Faye, Frédéric Le Marcis, Yazdan Yazdanpanah, Vinh-Kim Nguyen
Vaccination and blood sampling acceptability during Ramadan fasting month: A cross-sectional study in Conakry, Guinea
published pages: 2569-2574, ISSN: 0264-410X, DOI: 10.1016/j.vaccine.2017.03.068
Vaccine 35/19 2019-07-02
2016 Daouda Sissoko, Cedric Laouenan, Elin Folkesson, Abdoul-Bing M’Lebing, Abdoul-Habib Beavogui, Sylvain Baize, Alseny-Modet Camara, Piet Maes, Susan Shepherd, Christine Danel, Sara Carazo, Mamoudou N. Conde, Jean-Luc Gala, Géraldine Colin, Hélène Savini, Joseph Akoi Bore, Frederic Le Marcis, Fara Raymond Koundouno, Frédéric Petitjean, Marie-Claire Lamah, Sandra Diederich, Alexis Tounkara, Gee
Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea
published pages: e1001967, ISSN: 1549-1676, DOI: 10.1371/journal.pmed.1001967
PLOS Medicine 13/3 2019-07-02
2018 Frédéric Le Marcis, Daouda Sissoko, Xavier Anglaret and Denis Malvy
Doing Science in an Emergency. Challenging clinical trial standards and producing care.
published pages: , ISSN: , DOI:
Localizing Standards 2019-07-02
2017 Thi Huyen Tram Nguyen, Jérémie Guedj, Xavier Anglaret, Cédric Laouénan, Vincent Madelain, Anne-Marie Taburet, Sylvain Baize, Daouda Sissoko, Boris Pastorino, Anne Rodallec, Géraldine Piorkowski, Sara Carazo, Mamoudou N. Conde, Jean-Luc Gala, Joseph Akoi Bore, Caroline Carbonnelle, Frédéric Jacquot, Hervé Raoul, Denis Malvy, Xavier de Lamballerie, France Mentré
Favipiravir pharmacokinetics in Ebola-Infected patients of the JIKI trial reveals concentrations lower than targeted
published pages: e0005389, ISSN: 1935-2735, DOI: 10.1371/journal.pntd.0005389
PLOS Neglected Tropical Diseases 11/2 2019-07-02
2015 Frédéric Le Marcis
« Traiter les corps comme des fagots » Production sociale de l’indifférence en contexte Ebola (Guinée)
published pages: , ISSN: 2111-5028, DOI: 10.4000/anthropologiesante.1907
Anthropologie et Santé 11 2019-07-02
2017 Sophie Duraffour, Denis Malvy, Daouda Sissoko
How to treat Ebola virus infections? A lesson from the field
published pages: 9-15, ISSN: 1879-6257, DOI: 10.1016/j.coviro.2017.03.003
Current Opinion in Virology 24 2019-07-02
2016 Boubacar Diallo, Daouda Sissoko, Nicholas J. Loman, Hadja Aïssatou Bah, Hawa Bah, Mary Claire Worrell, lya Saidou Conde, Ramata Sacko, Samuel Mesfin, Angelo Loua, Jacques Katomba Kalonda, Ngozi A. Erondu, Benjamin A. Dahl, Susann Handrick, Ian Goodfellow, Luke W. Meredith, Matthew Cotten, Umaru Jah, Raoul Emeric Guetiya Wadoum, Pierre Rollin, N\'Faly Magassouba, Denis Malvy, Xavier Anglaret, Miles
Resurgence of Ebola Virus Disease in Guinea Linked to a Survivor With Virus Persistence in Seminal Fluid for More Than 500 Days
published pages: 1353-1356, ISSN: 1058-4838, DOI: 10.1093/cid/ciw601
Clinical Infectious Diseases 63/10 2019-07-02
2015 Vincent Madelain, Lisa Oestereich, Frederik Graw, Thi Huyen Tram Nguyen, Xavier de Lamballerie, France Mentré, Stephan Günther, Jeremie Guedj
Ebola virus dynamics in mice treated with favipiravir
published pages: 70-77, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2015.08.015
Antiviral Research 123 2019-07-02
2015 Paul Benkimoun, Gilbert Potier, Michel Janssens, Frédéric Le Marcis et Antoine Petibon
Ebola : chronique d’une catastrophe annoncée
published pages: , ISSN: 2105-2522, DOI:
Humanitaire 2019-07-02
2017 Daouda Sissoko, Mory Keïta, Boubacar Diallo, Negar Aliabadi, David L. Fitter, Benjamin A. Dahl, Joseph Akoi Bore, Fara Raymond Koundouno, Katrin Singethan, Sarah Meisel, Theresa Enkirch, Antonio Mazzarelli, Victoria Amburgey, Ousmane Faye, Amadou Alpha Sall, N’Faly Magassouba, Miles W. Carroll, Xavier Anglaret, Denis Malvy, Pierre Formenty, Raymond Bruce Aylward, Sakoba Keïta, Mamoudou Harouna
Ebola Virus Persistence in Breast Milk After No Reported Illness: A Likely Source of Virus Transmission From Mother to Child
published pages: ciw793, ISSN: 1058-4838, DOI: 10.1093/cid/ciw793
Clinical Infectious Diseases 2019-07-02
2015 Sylvain Landry Faye
L’« exceptionnalité » d’Ebola et les « réticences » populaires en Guinée-Conakry. Réflexions à partir d’une approche d’anthropologie symétrique
published pages: , ISSN: 2111-5028, DOI: 10.4000/anthropologiesante.1796
Anthropologie et Santé 11 2019-07-02
2017 Gomez-Temesio Veronica; Le Marcis, Frédéric
La mise en camp de la Guinée. Ebola et l\'expérience postcoloniale
published pages: 57-90, ISSN: 0439-4216, DOI:
L\'Homme - Revue française d\'anthropologie, Éditions de l\'EHESS 2017 2019-07-02
2016 Vincent Madelain, Jérémie Guedj, France Mentré, Thi Huyen Tram Nguyen, Frédéric Jacquot, Lisa Oestereich, Takumi Kadota, Koichi Yamada, Anne-Marie Taburet, Xavier de Lamballerie, Hervé Raoul
Favipiravir Pharmacokinetics in Nonhuman Primates and Insights for Future Efficacy Studies of Hemorrhagic Fever Viruses
published pages: e01305-16, ISSN: 0066-4804, DOI: 10.1128/AAC.01305-16
Antimicrobial Agents and Chemotherapy 61/1 2019-07-02
2015 Naïm Bouazza, Jean-Marc Treluyer, Frantz Foissac, France Mentré, Anne-Marie Taburet, Jérémie Guedj, Xavier Anglaret, Xavier de Lamballerie, Sakoba Keïta, Denis Malvy, Pierre Frange
Favipiravir for children with Ebola
published pages: 603-604, ISSN: 0140-6736, DOI: 10.1016/S0140-6736(15)60232-X
The Lancet 385/9968 2019-07-02
2018 Guedj J, Piorkowski G, Jacquot F, Madelain V, Nguyen T-H-T, Rodallec A, Gunther S, Carbonelle C, Mentré F, Raoul H, de Lamballerie X.
Antiviral efficacy of favipiravir against Ebola virus in cynomolgus macaques.
published pages: , ISSN: , DOI:
2019-07-02
2015 Yazdan Yazdanpanah, Peter Horby, Johan van Griensven, France Mentre, Vinh-Kim Nguyen, Jean Marie Denis Malvy, Jake Dunning, Daouda Sissoko, Jean-Francois Delfraissy, Yves Levy
Drug assessment in the Ebola virus disease epidemic in west Africa
published pages: 1258, ISSN: 1473-3099, DOI: 10.1016/S1473-3099(15)00344-8
The Lancet Infectious Diseases 15/11 2019-07-02
2017 Sylvain Laundry Faye
Confrontations des « grammaires » de la «participation» communautaire en contexte d’urgence sanitaire d’Ebola en Guinée Conakry
published pages: , ISSN: , DOI:
2019-07-02
2016 Vincent Madelain, Thi Huyen Tram Nguyen, Anaelle Olivo, Xavier de Lamballerie, Jérémie Guedj, Anne-Marie Taburet, France Mentré
Ebola Virus Infection: Review of the Pharmacokinetic and Pharmacodynamic Properties of Drugs Considered for Testing in Human Efficacy Trials
published pages: 907-923, ISSN: 0312-5963, DOI: 10.1007/s40262-015-0364-1
Clinical Pharmacokinetics 55/8 2019-07-02
2015 France Mentré, Anne-Marie Taburet, Jeremie Guedj, Xavier Anglaret, Sakoba Keïta, Xavier de Lamballerie, Denis Malvy
Dose regimen of favipiravir for Ebola virus disease
published pages: 150-151, ISSN: 1473-3099, DOI: 10.1016/S1473-3099(14)71047-3
The Lancet Infectious Diseases 15/2 2019-07-02
2015 Frédéric Le Marcis, Vinh-Kim Nguyen
An Ebola Photo Essay
published pages: , ISSN: , DOI:
Limn - Issue Number Five: Ebola\'s Ecologies Five 2019-07-02

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